Nerve growth factor‐induced sprouting of mature, uninjured sympathetic axons

The infusion of nerve growth factor (NGF) into the lateral ventricle ofthe mature rat brain elicits a sprouting response from axons associated with the intradural segment of the internal carotid artery. Using electron microscopic techniques, we observed a three–fold increase in the total number of perivascular axons. This NGF‐elicited response is characterized by a dramatic reduction in glial cell ensheathment similar to that observed during development and by the presence of profiles devoid of organelles that may represent newly formed sprouts. In spite of the increase in axon number, no significant changes in the percentage of small, medium, or large axons wereobserved.

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