Self-Assembly of Complex DNA Tessellations by Using Low-Symmetry Multi-arm DNA Tiles.

Modular DNA tile-based self-assembly is a versatile way to engineer basic tessellation patterns on the nanometer scale, but it remains challenging to achieve high levels of structural complexity. We introduce a set of general design principles to create intricate DNA tessellations by employing multi-arm DNA motifs with low symmetry. We achieved two novel Archimedean tiling patterns, (4.8.8) and (3.6.3.6), and one pattern with higher-order structures beyond the complexity observed in Archimedean tiling. Our success in assembling complicated DNA tessellations demonstrates the broad design space of DNA structural motifs, enriching the toolbox of DNA tile-based self-assembly and expanding the complexity boundaries of DNA tile-based tessellation.

[1]  J. G. Elias,et al.  The dimensions of DNA in solution. , 1981, Journal of molecular biology.

[2]  Hao Yan,et al.  Challenges and opportunities for structural DNA nanotechnology. , 2011, Nature nanotechnology.

[3]  M L Jackson,et al.  Rhodopsin-Phospholipid Reconstitution from Octyl Glucoside-solubilized Samples. , 1982, Biophysical journal.

[4]  A. Turberfield,et al.  Self-assembly of chiral DNA nanotubes. , 2004, Journal of the American Chemical Society.

[5]  J. Reif,et al.  DNA-Templated Self-Assembly of Protein Arrays and Highly Conductive Nanowires , 2003, Science.

[6]  N. Seeman.  Nucleic acid junctions and lattices. , 1982, Journal of theoretical biology.

[7]  Ye Tian,et al.  Geometric self-sorting in DNA self-assembly. , 2007, Chemical communications.

[8]  A. Tsai,et al.  Highly active quasicrystalline Al-Cu-Fe catalyst for steam reforming of methanol , 2001 .

[9]  Hao Yan,et al.  Structural DNA Nanotechnology: State of the Art and Future Perspective , 2014, Journal of the American Chemical Society.

[10]  Reza M. Zadegan,et al.  Structural DNA Nanotechnology: From Design to Applications , 2012, International journal of molecular sciences.

[11]  N. Seeman,et al.  Crystalline two-dimensional DNA-origami arrays. , 2011, Angewandte Chemie.

[12]  Hao Yan,et al.  Complex Archimedean tiling self-assembled from DNA nanostructures. , 2013, Journal of the American Chemical Society.

[13]  Hao Yan,et al.  Complex wireframe DNA origami nanostructures with multi-arm junction vertices. , 2015, Nature nanotechnology.

[14]  Thomas H. LaBean,et al.  Nanofabrication by DNA self-assembly , 2009 .

[15]  N. Seeman.  Nanomaterials based on DNA. , 2010, Annual review of biochemistry.

[16]  K. Kern,et al.  Engineering atomic and molecular nanostructures at surfaces , 2005, Nature.

[17]  Chengde Mao,et al.  Controlling the chirality of DNA nanocages. , 2012, Angewandte Chemie.

[18]  M. C. Netti,et al.  Complete photonic bandgaps in 12-fold symmetric quasicrystals , 2000, Nature.

[19]  Hao Yan,et al.  A study of DNA tube formation mechanisms using 4-, 8-, and 12-helix DNA nanostructures. , 2006, Journal of the American Chemical Society.

[20]  J. Dolinšek,et al.  Electrical and thermal transport properties of icosahedral and decagonal quasicrystals. , 2012, Chemical Society reviews.

[21]  A. Turberfield,et al.  Engineering a 2D protein-DNA crystal. , 2005, Angewandte Chemie.

[22]  Faisal A. Aldaye,et al.  Assembling Materials with DNA as the Guide , 2008, Science.

[23]  Chengde Mao,et al.  Highly connected two-dimensional crystals of DNA six-point-stars. , 2006, Journal of the American Chemical Society.