BMAL1 drives muscle repair through control of hypoxic NAD+ regeneration in satellite cells

Here, Zhu et al. identify a role for the adult muscle stem cell (MuSC)-autonomous clock in the control of muscle regeneration following acute ischemic injury. They observed greater muscle repair capacity following injury during the active/wake period as compared with the inactive/rest period in mice and that loss of Bmal1 within MuSCs leads to impaired muscle regeneration, and show that the MuSC clock is a pivotal regulator of oxygen-dependent myoblast cell fate and muscle repair through the control of the NAD+-driven response to injury.