Systematic evaluation of suspension MDCK cells, adherent MDCK cells, and LLC-MK2 cells for preparing influenza vaccine seed virus.

[1]  I. Barr,et al.  Cell culture-derived influenza vaccines in the severe 2017–2018 epidemic season: a step towards improved influenza vaccine effectiveness , 2018, npj Vaccines.

[2]  Ivo M Foppa,et al.  Annual estimates of the burden of seasonal influenza in the United States: A tool for strengthening influenza surveillance and preparedness , 2018, Influenza and other respiratory viruses.

[3]  Jan Kyncl,et al.  Estimates of global seasonal influenza-associated respiratory mortality: a modelling study , 2017, The Lancet.

[4]  M. Tashiro,et al.  Development of a high-yield reassortant influenza vaccine virus derived from the A/Anhui/1/2013 (H7N9) strain. , 2016, Vaccine.

[5]  Tiago J. S. Lopes,et al.  Development of high-yield influenza A virus vaccine viruses , 2015, Nature Communications.

[6]  C. Davis,et al.  Performance characteristics of qualified cell lines for isolation and propagation of influenza viruses for vaccine manufacturing , 2014, Vaccine.

[7]  U. Reichl,et al.  High cell density cultivations by alternating tangential flow (ATF) perfusion for influenza A virus production using suspension cells. , 2014, Vaccine.

[8]  U. Reichl,et al.  Impact of cultivation conditions on N‐glycosylation of influenza virus a hemagglutinin produced in MDCK cell culture , 2013, Biotechnology and bioengineering.

[9]  M. Tashiro,et al.  High Yield Production of Influenza Virus in Madin Darby Canine Kidney (MDCK) Cells with Stable Knockdown of IRF7 , 2013, PloS one.

[10]  W. Garten,et al.  Isolation of influenza viruses in MDCK 33016PF cells and clearance of contaminating respiratory viruses , 2011, Vaccine.

[11]  H. Schmitt,et al.  Safety of MDCK cell culture-based influenza vaccines. , 2011, Future microbiology.

[12]  Tomoyuki N. Tanaka,et al.  One-step real-time reverse transcription-PCR assays for detecting and subtyping pandemic influenza A/H1N1 2009, seasonal influenza A/H1N1, and seasonal influenza A/H3N2 viruses , 2010, Journal of Virological Methods.

[13]  Stephen W. Brown,et al.  The Avian EB66(R) Cell Line, Application to Vaccines, and Therapeutic Protein Production. , 2010, PDA journal of pharmaceutical science and technology.

[14]  James Paulson,et al.  Receptor Specificity of Influenza A H3N2 Viruses Isolated in Mammalian Cells and Embryonated Chicken Eggs , 2010, Journal of Virology.

[15]  C. McLeod,et al.  Rapid generation of a well-matched vaccine seed from a modern influenza A virus primary isolate without recourse to eggs. , 2010, Vaccine.

[16]  S. Halperin,et al.  Trivalent MDCK cell culture-derived influenza vaccine Optaflu® (Novartis Vaccines) , 2009, Expert review of vaccines.

[17]  J. Gregersen.  A quantitative risk assessment of exposure to adventitious agents in a cell culture-derived subunit influenza vaccine , 2008, Vaccine.

[18]  J. Gregersen.  A risk-assessment model to rate the occurrence and relevance of adventitious agents in the production of influenza vaccines , 2008, Vaccine.

[19]  H. Jin,et al.  Stabilizing the glycosylation pattern of influenza B hemagglutinin following adaptation to growth in eggs. , 2008, Vaccine.

[20]  C. Bridges,et al.  The annual impact of seasonal influenza in the US: measuring disease burden and costs. , 2007, Vaccine.

[21]  R. Webster,et al.  Molecular changes associated with adaptation of human influenza A virus in embryonated chicken eggs. , 2006, Virology.

[22]  M. Tashiro,et al.  Antigenic alteration of influenza B virus associated with loss of a glycosylation site due to host‐cell adaptation , 2004, Journal of medical virology.

[23]  J. Taubenberger,et al.  Integrating historical, clinical and molecular genetic data in order to explain the origin and virulence of the 1918 Spanish influenza virus. , 2001, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[24]  Martin H. Koldijk,et al.  The human cell line PER.C6 provides a new manufacturing system for the production of influenza vaccines. , 2001, Vaccine.

[25]  N. Cox,et al.  Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness. , 1998, Science.

[26]  R. Webster,et al.  African green monkey kidney (Vero) cells provide an alternative host cell system for influenza A and B viruses , 1996, Journal of virology.

[27]  R. Webster,et al.  Replication of influenza A viruses in a green monkey kidney continuous cell line (Vero). , 1995, The Journal of infectious diseases.

[28]  N. Cox,et al.  Comparison of 10 influenza A (H1N1 and H3N2) haemagglutinin sequences obtained directly from clinical specimens to those of MDCK cell- and egg-grown viruses. , 1993, The Journal of general virology.

[29]  R. Webster,et al.  Influence of host cell-mediated variation on the international surveillance of influenza A (H3N2) viruses. , 1993, Virology.

[30]  T. Kok,et al.  The use of MDCK, MEK and LLC-MK2 cell lines with enzyme immunoassay for the isolation of influenza and parainfluenza viruses from clinical specimens. , 1993, Journal of virological methods.

[31]  J. Wood,et al.  Sequence analysis of the haemagglutinin (HA) of influenza A (H1N1) viruses present in clinical material and comparison with the HA of laboratory-derived virus. , 1991, The Journal of general virology.

[32]  J. Wood,et al.  The hemagglutinin of influenza B virus present in clinical material is a single species identical to that of mammalian cell-grown virus. , 1990, Virology.

[33]  J. Oxford,et al.  Evidence for host-cell selection of influenza virus antigenic variants , 1983, Nature.

[34]  K. Tobita,et al.  Plaque assay and primary isolation of influenza a viruses in an established line of canine kidney cells (MDCK) in the presence of trypsin , 1975, Medical Microbiology and Immunology.

[35]  W. Cherry,et al.  GROWTH CHARACTERISTICS OF MONKEY KIDNEY CELL STRAINS LLC-MK1, LLC-MK2, AND LLC-MK2(NCTC-3196) AND THEIR UTILITY IN VIRUS RESEARCH , 1962, The Journal of experimental medicine.

[36]  Jie Dong,et al.  Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus. , 2018 .

[37]  A. Evans,et al.  Rapid diagnostic methods for influenza virus in clinical specimens: a comparative study. , 1982, The Yale journal of biology and medicine.