Afferents to the flocculus of the cerebellum in the rhesus macaque as revealed by retrograde transport of horseradish peroxidase

To investigate the afferent projections to the flocculus in a nonhuman primate, we injected horseradish peroxidase into one flocculus of six rhesus macaques (Macaca mulatta) and processed their brains according to the tetramethylbenzidine protocol to reveal retrogradely labeled neurons. Labeled neurons were found in a large set of nuclei within the rostral medulla and the pons.

[1]  V. Henn,et al.  Vertical eye movement related unit activity in the rostral mesencephalic reticular formation of the alert monkey , 1977, Brain Research.

[2]  F. Walberg,et al.  Cerebellar afferents from neurons in motor nuclei of cranial nerves demonstrated by retrograde axonal transport of horseradish peroxidase , 1977, Brain Research.

[3]  A. Fuchs,et al.  Role of primate flocculus during rapid behavioral modification of vestibuloocular reflex. I. Purkinje cell activity during visually guided horizontal smooth-pursuit eye movements and passive head rotation. , 1978, Journal of neurophysiology.

[4]  J. Kimm,et al.  Anatomical evidence that the medial terminal nucleus of the accessory optic tract in mammals provides a visual mossy fiber input to the flocculus , 1978, Brain Research.

[5]  Thomas P. Langer Basal interstitial nucleus of the cerebellum: Cerebellar nucleus related to the flocculus , 1985, The Journal of comparative neurology.

[6]  J. Lafleur,et al.  Physiopathology of the cerebellum in the monkey , 1974 .

[7]  D. A. Suzuki,et al.  Processing of eye movement signals in the flocculus of the monkey. , 1979, The Journal of physiology.

[8]  J. Goldberg,et al.  Physiology of peripheral neurons innervating semicircular canals of the squirrel monkey. I. Resting discharge and response to constant angular accelerations. , 1971, Journal of neurophysiology.

[9]  F A Miles,et al.  Visual tracking and the primate flocculus. , 1975, Science.

[10]  S Takemori,et al.  Loss of visual suppression of vestibular nystagmus after flocculus lesions. , 1974, Brain research.

[11]  D. Haines,et al.  The inferior olive of a prosimian primate, Galago senegalensis. II. Olivocerebellar projections to the vestibulocerebellum , 1983, The Journal of comparative neurology.

[12]  E. Keller,et al.  Neuronal responses to optokinetic stimuli in pontine nuclei of behaving monkey. , 1983, Journal of neurophysiology.

[13]  E. Taber The cytoarchitecture of the brain stem of the cat. I. Brain stem nuclei of cat , 1961, The Journal of comparative neurology.

[14]  A. Fuchs,et al.  Role of primate flocculus during rapid behavioral modification of vestibuloocular reflex. II. Mossy fiber firing patterns during horizontal head rotation and eye movement. , 1978, Journal of neurophysiology.

[15]  R. Giolli,et al.  Accessory optic system of rhesus monkey , 1979, Experimental Neurology.

[16]  A. Brodal,et al.  Cerebellar projection of paramedian reticular nucleus of medulla oblongata in cat. , 1954, Journal of neurophysiology.

[17]  D. Haines,et al.  Secondary vestibulocerebellar projections to flocculonodular lobe in a prosimian primate, Galago senegalensis , 1981, The Journal of comparative neurology.

[18]  T. Hashikawa,et al.  Olivocerebellar projections in the cat studied by means of anterograde axonal transport of labeled amino acids as tracers , 1979, Neuroscience.

[19]  S. Nakao,et al.  Eye movement related neurons in the cat pontine reticular formation: projection to the flocculus , 1980, Brain Research.

[20]  C. Kaneko,et al.  Vestibular and medullary brain stem afferents to the abducens nucleus in the cat , 1977, Brain Research.

[21]  G. Carl Huber 1865–1934 In Memoriam , 1935 .

[22]  P. Brodal,et al.  The corticopontine projection in the rhesus monkey. Origin and principles of organization. , 1978, Brain : a journal of neurology.

[23]  A. Fuchs,et al.  Floccular efferents in the rhesus macaque as revealed by autoradiography and horseradish peroxidase , 1985, The Journal of comparative neurology.

[24]  F. Walberg,et al.  The raphe nuclei of the brain stem in the cat. I. Normal topography and cytoarchitecture and general discussion , 1960, The Journal of comparative neurology.

[25]  A. Fuchs,et al.  Unit activity in vestibular nucleus of the alert monkey during horizontal angular acceleration and eye movement. , 1975, Journal of neurophysiology.

[26]  N. Gerrits,et al.  The climbing fiber projection to the flocculus and adjacent paraflocculus in the cat , 1982, Neuroscience.

[27]  Yu Sato,et al.  Afferent projections from the brainstem to the three floccular zones in cats. II. Mossy fiber projections , 1983, Brain Research.

[28]  Toshiaki Takeda,et al.  Neural activity of nucleus reticularis tegmenti pontis — the origin of visual mossy fiber afferents to the cerebellar flocculus of rabbits , 1981, Brain Research.

[29]  M. Mesulam,et al.  Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: a non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents. , 1978, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[30]  P. Brodal,et al.  Further observations on the cerebellar projections from the pontine nuclei and the nucleus reticularis tegmenti pontis in the rhesus monkey , 1982, The Journal of comparative neurology.

[31]  J. Olszewski,et al.  Cytoarchitecture of the Human Brain Stem , 1955 .

[32]  D. Zee,et al.  Effects of ablation of flocculus and paraflocculus of eye movements in primate. , 1981, Journal of neurophysiology.

[33]  F. Walberg,et al.  The olivocerebellar projections to the flocculus and paraflocculus in the cat, compared to those in the rabbit. A study using horseradish peroxidase as a tracer , 1979, Brain Research.

[34]  M. Carpenter,et al.  Primary vestibulocerebellar fibers in the monkey: distribution of fibers arising from distinctive cell groups of the vestibular ganglia. , 1972, The American journal of anatomy.

[35]  M. Carpenter,et al.  Cerebellum of the rhesus monkey : atlas of lobules, laminae, and folia, in sections , 1971 .

[36]  L. Benevento,et al.  An autoradiographic study of the projections of the pretectum in the rhesus monkey (macaca mulatta): evidence for sensorimotor links to the thalamus and oculomotor nuclei , 1977, Brain Research.

[37]  O. Pompeiano,et al.  The vestibular nuclei in cat. , 1957, Journal of anatomy.

[38]  A. Brodal,et al.  The olivocerebellar projection studied with the method of retrograde axonal transport of horseradish peroxidase. V. The projections to the flocculonodular lobe and the paraflocculus in the rabbit , 1977, The Journal of comparative neurology.

[39]  L. Heimer,et al.  Two methods for selective silver impregnation of degenerating axons and their synaptic endings in the central nervous system. , 1967, Brain research.

[40]  A. Berthoz,et al.  Neuronal activity in prepositus nucleus correlated with eye movement in the alert cat. , 1982, Journal of neurophysiology.

[41]  J. K. Harting Descending pathways from the superior colliculus: An autoradiographic analysis in the rhesus monkey (Macaca mulatta) , 1977, The Journal of comparative neurology.

[42]  G. Leichnetz,et al.  The prefrontal cortico-oculomotor trajectories in the monkey A possible explanation for the effects of stimulation/lesion experiments on eye movement , 1981, Journal of the Neurological Sciences.

[43]  A. Brodal,et al.  SITE AND MODE OF TERMINATION OF PRIMARY VESTIBULOCEREBELLAR FIBRES IN THE CAT. AN EXPERIMENTAL STUDY WITH SILVER IMPREGNATION METHODS. , 1964, Archives italiennes de biologie.

[44]  J. Kaas,et al.  Subcortical projections of six visual cortical areas in the owl monkey, Aotus trivirgatus , 1979, The Journal of comparative neurology.

[45]  J. Simpson,et al.  Afferents to the vestibulo-cerebellum and the origin of the visual climbing fibers in the rabbit , 1975, Brain Research.

[46]  A. Weiss,et al.  Vestibular projections to the nuclei of the extraocular muscles. Degeneration resulting from discrete partial lesions of the vestibular nuclei in the monkey. , 1966, The American journal of anatomy.

[47]  E. Keller,et al.  NEURAL ACTIVITY IN THE NUCLEUS RETICULARIS TEGMENTI PONTIS IN THE MONKEY RELATED TO EYE MOVEMENTS AND VISUAL STIMULATION * , 1981, Annals of the New York Academy of Sciences.

[48]  Yu Sato,et al.  Afferent projection from the dorsal nucleus of the raphe to the flocculus in cats , 1980, Brain Research.

[49]  K. Akert,et al.  Efferent connections of cortical, area 8 (frontal eye field) in Macaca fascicularis. A reinvestigation using the autoradiographic technique , 1977, The Journal of comparative neurology.

[50]  A. Gibson,et al.  Corticopontine visual projections in macaque monkeys , 1980, The Journal of comparative neurology.

[51]  Miyuki Yamamoto Topographical representation in rabbit cerebellar flocculus for various afferent inputs from the brainstem investigated by means of retrograde axonal transport of horseradish peroxidase , 1979, Neuroscience Letters.

[52]  H. Noda,et al.  VISUAL MOSSY FIBER INPUTS TO THE FLOCCULUS OF THE MONKEY * , 1981, Annals of the New York Academy of Sciences.

[53]  A. Fuchs,et al.  Reticular control of vertical saccadic eye movements by mesencephalic burst neurons. , 1979, Journal of neurophysiology.

[54]  M. Karnovsky,et al.  THF EARLY STAGES OF ABSORPTION OF INJECTED HORSERADISH PEROXIDASE IN THE PROXIMAL TUBULES OF MOUSE KIDNEY: ULTRASTRUCTURAL CYTOCHEMISTRY BY A NEW TECHNIQUE , 1966, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[55]  E. Mugnaini,et al.  The cerebellar projection of the vestibular nerve in the cat , 1979, The Journal of comparative neurology.