The 5-HT(2C/2B) receptor agonist, m-chlorophenylpiperazine, increases plasma glucagon levels in rats.

Effects of the 5-HT(2C/2B) receptor agonist m-chlorophenylpiperazine (mCPP) on plasma glucagon levels were investigated in rats. mCPP dose dependently increased plasma glucagon levels. Hyperglucagonemia elicited by mCPP was prevented by the 5-HT(2A/2B/2C) receptor antagonist, ritanserin, while the 5-HT(2A) receptor antagonist, ketanserin, did not show any effect. Increases in glucagon levels induced by mCPP were inhibited by prior adrenodemedullation. These results indicate that increases in plasma glucagon levels induced by mCPP are mediated by the 5-HT(2C/2B) receptor which in turn facilitates adrenaline release.

[1]  K. Fone,et al.  Distribution of the 5‐hydroxytryptamine2C receptor protein in adult rat brain and spinal cord determined using a receptor‐directed antibody: Effect of 5,7‐dihydroxytryptamine , 1997, Synapse.

[2]  G. Curzon.  Serotonin and Appetite , 1990, Annals of the New York Academy of Sciences.

[3]  Y. Sugimoto,et al.  Effects of the 5-HT2C/2B receptor agonist 1-(3-chlorophenyl) piperazine on plasma glucose levels of rats. , 1996, European journal of pharmacology.

[4]  D. Laude,et al.  Evidence that the 5-HT1A receptor agonists buspirone and ipsapirone activate adrenaline release in the conscious rat. , 1990, European journal of pharmacology.

[5]  G. Kennett,et al.  Potencies of antagonists indicate that 5‐HT1C receptors mediate 1–3(chlorophenyl)piperazine‐induced hypophagia , 1991, British journal of pharmacology.

[6]  D. Murphy,et al.  Different serotonin receptors mediate blood pressure, heart rate, plasma catecholamine and prolactin responses to m-chlorophenylpiperazine in conscious rats. , 1989, The Journal of pharmacology and experimental therapeutics.

[7]  G. Kennett,et al.  Evidence that mCPP may have behavioural effects mediated by central 5‐HT1C receptors , 1988, British journal of pharmacology.

[8]  G. Kennett,et al.  m-CPP: a tool for studying behavioural responses associated with 5-HT1c receptors. , 1990, Trends in pharmacological sciences.

[9]  B. Ahrén,et al.  α1- and α2-adrenoceptor activation increases plasma glucagon levels in the mouse , 1987 .

[10]  A. Kelley,et al.  Enhanced reward‐related responding following cholera toxin infusion into the nucleus accumbens , 1997, Synapse.

[11]  G. Martin,et al.  5-HT Receptor Classification and Nomenclature: Towards a Harmonization with the Human Genome , 1997, Neuropharmacology.

[12]  F. Blaney,et al.  5-HT2 receptor subtypes: a family re-united? , 1995, Trends in pharmacological sciences.

[13]  D. Laude,et al.  Effects of the 5-HT1C/5-HT2 receptor agonists DOI and α-methyl-5-HT on plasma glucose and insulin levels in the rat , 1990 .

[14]  Y. Sugimoto,et al.  The effects of the serotonin1A receptor agonist buspirone on the blood glucose and pancreatic hormones in rats. , 1992, Japanese journal of pharmacology.

[15]  M. Pompeiano,et al.  Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors. , 1994, Brain research. Molecular brain research.

[16]  D. Murphy,et al.  The serotonin agonist, M-chlorophenyl-piperazine, markedly increases levels of plasma catecholamines in the conscious rat , 1988, Neuropharmacology.

[17]  G. Bagdy.  Role of the hypothalamic paraventricular nucleus in 5-HT1A , 5-HT2A and 5-HT2C receptor-mediated oxytocin, prolactin and ACTH/corticosterone responses , 1995, Behavioural Brain Research.

[18]  D. Laude,et al.  Ganglionic transmission is a prerequisite for the adrenaline-releasing and hyperglycemic effects of 8-OH-DPAT. , 1990, European journal of pharmacology.

[19]  P P Humphrey,et al.  International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). , 1994, Pharmacological reviews.

[20]  J. Leysen,et al.  Receptor binding profile of R 41 468, a novel antagonist at 5-HT2 receptors. , 1981, Life sciences.

[21]  F. Chaouloff,et al.  5-HT1A and alpha-2 adrenergic receptors mediate the hyperglycemic and hypoinsulinemic effects of 8-hydroxy-2-(di-n-propylamino)tetralin in the conscious rat. , 1987, The Journal of pharmacology and experimental therapeutics.

[22]  G. Bagdy,et al.  Effect of 5-HT1C and 5-HT2 receptor stimulation on excessive grooming, penile erection and plasma oxytocin concentrations. , 1992, European journal of pharmacology.