Molecular mechanisms of erbB2-mediated breast cancer chemoresistance.
暂无分享,去创建一个
[1] M. Ellis,et al. Study of the biologic effects of lapatinib, a reversible inhibitor of ErbB1 and ErbB2 tyrosine kinases, on tumor growth and survival pathways in patients with advanced malignancies. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[2] Ingo K Mellinghoff,et al. HER2/neu kinase-dependent modulation of androgen receptor function through effects on DNA binding and stability. , 2004, Cancer cell.
[3] L. Brannon-Peppas,et al. Nanoparticle and targeted systems for cancer therapy. , 2004, Advanced drug delivery reviews.
[4] M. Hung,et al. Enhanced paclitaxel cytotoxicity and prolonged animal survival rate by a nonviral-mediated systemic delivery of E1A gene in orthotopic xenograft human breast cancer , 2004, Cancer Gene Therapy.
[5] Hiroyuki Honda,et al. Magnetite nanoparticle-loaded anti-HER2 immunoliposomes for combination of antibody therapy with hyperthermia. , 2004, Cancer letters.
[6] R. Schiff,et al. Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer. , 2004, Journal of the National Cancer Institute.
[7] Naoto T. Ueno,et al. P27kip1 Down-Regulation Is Associated with Trastuzumab Resistance in Breast Cancer Cells , 2004, Cancer Research.
[8] Ramaswamy Nilakantan,et al. Antitumor Activity of HKI-272, an Orally Active, Irreversible Inhibitor of the HER-2 Tyrosine Kinase , 2004, Cancer Research.
[9] Gordon B Mills,et al. Lineage Infidelity of MDA-MB-435 Cells , 2004, Cancer Research.
[10] M. Gore,et al. A Multicenter Phase I Gene Therapy Clinical Trial Involving Intraperitoneal Administration of E1A-Lipid Complex in Patients with Recurrent Epithelial Ovarian Cancer Overexpressing HER-2/neu Oncogene , 2004, Clinical Cancer Research.
[11] Ming Tan,et al. PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. , 2004, Cancer cell.
[12] R. Bast,et al. Inhibition of Breast and Ovarian Tumor Growth through Multiple Signaling Pathways by Using Retrovirus-mediated Small Interfering RNA against Her-2/neu Gene Expression* , 2004, Journal of Biological Chemistry.
[13] J. Garcia-conde,et al. Biweekly paclitaxel plus gemcitabine in advanced breast cancer: phase II trial and predictive value of HER2 extracellular domain. , 2004, Annals of oncology : official journal of the European Society for Medical Oncology.
[14] K. Gelmon,et al. Pharmacodynamic Behavior of Liposomal Antisense Oligonucleotides Targeting Her-2/neu and Vascular Endothelial Growth Factor in an Ascitic MDA435/LCC6 Human Breast Cancer Model , 2004, Cancer biology & therapy.
[15] K. Garber. Improved Paclitaxel formulation hints at new chemotherapy approach. , 2004, Journal of the National Cancer Institute.
[16] B. Groner,et al. Regression of Cutaneous Tumor Lesions in Patients Intratumorally Injected with a Recombinant Single-chain Antibody-toxin Targeted to ErbB2/HER2 , 2003, Breast Cancer Research and Treatment.
[17] E. Chang,et al. HER‐2‐Targeted Antisense Oligonucleotide Results in Sensitization of Head and Neck Cancer Cells to Chemotherapeutic Agents , 2003, Annals of the New York Academy of Sciences.
[18] K. Bloom,et al. HER-2/neu testing in breast cancer. , 2003, American journal of clinical pathology.
[19] G. Hortobagyi,et al. Neoadjuvant chemotherapy for breast carcinoma , 2003, Cancer.
[20] Terry L. Smith,et al. ErbB2 overexpression in human breast carcinoma is correlated with p21Cip1 up‐regulation and tyrosine‐15 hyperphosphorylation of p34Cdc2 , 2003, Cancer.
[21] K. Mayne,et al. 672 Randomised phase II trial (M77001) of trastuzumab (Herceptin®) plus docetaxel versus docetaxel alone, as first-line therapy in patients with HER2-positive metastitic breast cancer , 2003 .
[22] R. Bast,et al. The Role of Cyclin-dependent Kinase Inhibitor p27Kip1 in Anti-HER2 Antibody-induced G1 Cell Cycle Arrest and Tumor Growth Inhibition* , 2003, Journal of Biological Chemistry.
[23] G. Mills,et al. HER2/PI-3K/Akt activation leads to a multidrug resistance in human breast adenocarcinoma cells , 2003, Oncogene.
[24] K. Tanabe,et al. Antisense Bcl-2 and HER-2 oligonucleotide treatment of breast cancer cells enhances their sensitivity to anticancer drugs. , 2003, International journal of oncology.
[25] N. Hynes,et al. The ErbB receptors and their role in cancer progression. , 2003, Experimental cell research.
[26] S. Hilsenbeck,et al. Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer. , 2003, Journal of the National Cancer Institute.
[27] A. Berezov,et al. Antibody like peptidomimetics as large scale immunodetection probes. , 2003, Cellular and Molecular Biology.
[28] Jayanth Panyam,et al. Biodegradable nanoparticles for drug and gene delivery to cells and tissue. , 2003, Advanced drug delivery reviews.
[29] A. M. Stanley,et al. Structure of the extracellular region of HER 2 alone and in complex with the Herceptin Fab , 2022 .
[30] V. Chinchilli,et al. Decreased Response to Paclitaxel Versus Docetaxel in HER-2/neu Transfected Human Breast Cancer Cells , 2003, American journal of clinical oncology.
[31] Michael Kofler,et al. The crystal structure of a truncated ErbB2 ectodomain reveals an active conformation, poised to interact with other ErbB receptors. , 2003, Molecular cell.
[32] Mitchell D Schnall,et al. Conditional activation of Neu in the mammary epithelium of transgenic mice results in reversible pulmonary metastasis. , 2002, Cancer cell.
[33] M. Hung,et al. Systemic gene therapy in human xenograft tumor models by liposomal delivery of the E1A gene. , 2002, Cancer research.
[34] G. Hortobagyi,et al. Enhanced sensitization to taxol-induced apoptosis by herceptin pretreatment in ErbB2-overexpressing breast cancer cells. , 2002, Cancer research.
[35] A. Berezov,et al. Disabling Receptor Ensembles with Rationally Designed Interface Peptidomimetics* , 2002, The Journal of Biological Chemistry.
[36] E. Chang,et al. Tumor-targeting, Systemically Delivered Antisense HER-2 Chemosensitizes Human Breast Cancer Xenografts Irrespective of HER-2 Levels , 2002, Molecular medicine.
[37] W. Wilmanns,et al. Clinical Relevance of Soluble c-erbB-2 for Patients with Metastatic Breast Cancer Predicting the Response to Second-Line Hormone or Chemotherapy , 2002, Tumor Biology.
[38] J. Bergh,et al. C-erbB-2 expression does not predict response to docetaxel or sequential methotrexate and 5-fluorouracil in advanced breast cancer. , 2002, European journal of cancer.
[39] A. Ullrich,et al. Smart drugs: tyrosine kinase inhibitors in cancer therapy. , 2002, Cancer cell.
[40] G. Hortobagyi,et al. Cationic liposome-mediated E1A gene transfer to human breast and ovarian cancer cells and its biologic effects: a phase I clinical trial. , 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[41] M. Kaku,et al. Increased Sensitivity to Cisplatin in Gastric Cancer by Antisense Inhibition of the HER-2/neu (c-erbB-2) Gene , 2001, Chemotherapy.
[42] Y. Yarden,et al. Untangling the ErbB signalling network , 2001, Nature Reviews Molecular Cell Biology.
[43] T. K. Yeung,et al. Enhanced drug resistance in cells coexpressing ErbB2 with EGF receptor or ErbB3. , 2000, Biochemical and biophysical research communications.
[44] Martin R. Johnson,et al. A cancer gene therapy approach utilizing an anti-erbB-2 single-chain antibody-encoding adenovirus (AD21): a phase I trial. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.
[45] M. Hung,et al. Role of erbB2 in breast cancer chemosensitivity. , 2000, BioEssays : news and reviews in molecular, cellular and developmental biology.
[46] B. Lloveras,et al. Circulating HER2 extracellular domain and resistance to chemotherapy in advanced breast cancer. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.
[47] R. Stein,et al. Evolutionary Analysis of the ErbB Receptor and Ligand Families , 2000, Journal of Molecular Evolution.
[48] G. Tortora,et al. Resistance to taxanes is induced by c‐erbB‐2 overexpression in human MCF‐10A mammary epithelial cells and is blocked by combined treatment with an antisense oligonucleotide targeting type I protein kinase A , 2000, International journal of cancer.
[49] Donald M. O'Rourke,et al. Rationally designed anti-HER2/neu peptide mimetic disables P185HER2/neu tyrosine kinases in vitro and in vivo , 2000, Nature Biotechnology.
[50] J. Cusack,et al. Control of inducible chemoresistance: Enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-κB , 1999, Nature Medicine.
[51] M. Sliwkowski,et al. Binding specificities and affinities of egf domains for ErbB receptors , 1999, FEBS letters.
[52] G. Hortobagyi,et al. Tyrosine kinase inhibitor emodin suppresses growth of HER-2/neu-overexpressing breast cancer cells in athymic mice and sensitizes these cells to the inhibitory effect of paclitaxel. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.
[53] Jun Yao,et al. Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase. , 1998, Molecular cell.
[54] R. Finn,et al. Remission of human breast cancer xenografts on therapy with humanized monoclonal antibody to HER-2 receptor and DNA-reactive drugs , 1998, Oncogene.
[55] D Tripathy,et al. Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment. , 1998, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[56] C. Dittrich,et al. Effects of retinoic acid and fenretinide on the c-erbB-2 expression, growth and cisplatin sensitivity of breast cancer cells. , 1998, British Journal of Cancer.
[57] L. Norton,et al. Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu overexpressing human breast cancer xenografts. , 1998, Cancer research.
[58] J. Isola,et al. Predictive value of topoisomerase IIalpha and other prognostic factors for epirubicin chemotherapy in advanced breast cancer. , 1998, British Journal of Cancer.
[59] S. Dickman. Antibodies Stage a Comeback in Cancer Treatment , 1998, Science.
[60] G. Hortobagyi,et al. Overexpression of both p185c-erbB2 and p170mdr-1 renders breast cancer cells highly resistant to taxol , 1998, Oncogene.
[61] A. Vincent-Salomon,et al. No significant predictive value of c‐ erbB‐2 or p53 expression regarding sensitivity to primary chemotherapy or radiotherapy in breast cancer , 1998, International journal of cancer.
[62] T. Fehm,et al. The Prognostic Significance of c-erbB-2 Serum Protein in Metastatic Breast Cancer , 1997, Oncology.
[63] M. Hung,et al. Chemosensitization of HER-2/neu-overexpressing human breast cancer cells to paclitaxel (Taxol) by adenovirus type 5 E1A , 1997, Oncogene.
[64] R. Finn,et al. The effect of HER-2/neu overexpression on chemotherapeutic drug sensitivity in human breast and ovarian cancer cells , 1997, Oncogene.
[65] N. Hynes,et al. ErbB‐2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling , 1997, The EMBO journal.
[66] Dihua Yu,et al. Overexpression of the c-erbB-2 gene enhanced intrinsic metastasis potential in human breast cancer cells without increasing their transformation abilities. , 1997, Cancer research.
[67] M. Hung,et al. Overexpression of c-erbB-2/neu in breast cancer cells confers increased resistance to Taxol via mdr-1-independent mechanisms. , 1996, Oncogene.
[68] D. Curiel,et al. Novel gene therapy strategy to accomplish growth factor modulation induces enhanced tumor cell chemosensitivity. , 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.
[69] Y. Yarden,et al. Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. , 1996, The EMBO journal.
[70] D Tripathy,et al. Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer. , 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[71] Y. Yarden,et al. ErbB‐2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer. , 1996, The EMBO journal.
[72] M. Hung,et al. Liposome-mediated in vivo E1A gene transfer suppressed dissemination of ovarian cancer cells that overexpress HER-2/neu. , 1995, Oncogene.
[73] T. van Raaij,et al. The cellular response to neuregulins is governed by complex interactions of the erbB receptor family , 1995, Molecular and cellular biology.
[74] C. Gao,et al. Induction of cyclin B and H1 kinase activity in apoptotic PC12 cells. , 1995, Experimental cell research.
[75] C. Shapiro,et al. Treatment of metastatic breast cancer: present and future prospects. , 1995, Seminars in oncology.
[76] G. Finocchiaro,et al. Mutation rate of the CDKN2 gene in malignant gliomas. , 1994, Cancer research.
[77] F. Ciardiello,et al. Induction of multidrug resistance (MDR) by transfection of MCF‐10A cell line with c‐Ha‐ras and c‐erbB‐2 oncogenes , 1994, International journal of cancer.
[78] D. Curiel,et al. Intracellular single-chain antibody directed against erbB2 down-regulates cell surface erbB2 and exhibits a selective anti-proliferative effect in erbB2 overexpressing cancer cell lines. , 1994, Gene therapy.
[79] D. Fisher. Apoptosis in cancer therapy: Crossing the threshold , 1994, Cell.
[80] M. Lippman,et al. Overview of the biologic markers of breast cancer. , 1994, Hematology/oncology clinics of North America.
[81] P. Carroll,et al. Heterogeneity of erbB-2 gene amplification in bladder cancer. , 1993, Cancer research.
[82] G. Nicolson,et al. Mechanisms of c-erbB2/neu oncogene-induced metastasis and repression of metastatic properties by adenovirus 5 E1A gene products. , 1992, Oncogene.
[83] B. Gusterson,et al. Prognostic importance of c-erbB-2 expression in breast cancer. International (Ludwig) Breast Cancer Study Group. , 1992, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[84] L. Presta,et al. Humanization of an anti-p185HER2 antibody for human cancer therapy. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[85] C. Osborne,et al. HER-2/neu in node-negative breast cancer: prognostic significance of overexpression influenced by the presence of in situ carcinoma. , 1992, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[86] K. Sugimachi,et al. Prognostic value of c-erbB-2 protein expression in human lung adenocarcinoma and squamous cell carcinoma. , 1991, European journal of cancer.
[87] N. Lemoine,et al. Amplification and overexpression of the EGF receptor and c-erbB-2 proto-oncogenes in human stomach cancer. , 1991, British Journal of Cancer.
[88] M. Hung,et al. Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene , 1991, Molecular and cellular biology.
[89] G. Stenman,et al. Expression of the ERBB2 protein in benign and malignant salivary gland tumors , 1991, Genes, chromosomes & cancer.
[90] M. Hung,et al. Transcriptional repression of the neu protooncogene by the adenovirus 5 E1A gene products. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[91] W Godolphin,et al. Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. , 1989, Science.
[92] B. Seliger,et al. Small interfering RNA (siRNA) inhibits the expression of the Her2/neu gene, upregulates HLA class I and induces apoptosis of Her2/neu positive tumor cell lines , 2004, International journal of cancer.
[93] T. Fleming,et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. , 2001, The New England journal of medicine.
[94] A. Al Moustafa,et al. The role of ErbB-2 tyrosine kinase receptor in cellular intrinsic chemoresistance: mechanisms and implications. , 1997, Biochemistry and cell biology = Biochimie et biologie cellulaire.
[95] R. Weinberg,et al. Molecular cloning of the neu gene: absence of gross structural alteration in oncogenic alleles. , 1986, Proceedings of the National Academy of Sciences of the United States of America.