${\mbi{\mu }}$-Foil Polymer Electrode Array for Intracortical Neural Recordings

We have developed a multichannel electrode array-termed μ-foil-that comprises ultrathin and flexible electrodes protruding from a thin foil at fixed distances. In addition to allowing some of the active sites to reach less compromised tissue, the barb-like protrusions that also serves the purpose of anchoring the electrode array into the tissue. This paper is an early evaluation of technical aspects and performance of this electrode array in acute in vitro/in vivo experiments. The interface impedance was reduced by up to two decades by electroplating the active sites with platinum black. The platinum black also allowed for a reduced phase lag for higher frequency components. The distance between the protrusions of the electrode array was tailored to match the architecture of the rat cerebral cortex. In vivo acute measurements confirmed a high signal-to-noise ratio for the neural recordings, and no significant crosstalk between recording channels.

[1]  Thomas Stieglitz,et al.  In vitro evaluation of the long-term stability of polyimide as a material for neural implants. , 2010, Biomaterials.

[2]  R A Normann,et al.  The Utah intracortical Electrode Array: a recording structure for potential brain-computer interfaces. , 1997, Electroencephalography and clinical neurophysiology.

[3]  K. E. Jones,et al.  A glass/silicon composite intracortical electrode array , 2006, Annals of Biomedical Engineering.

[4]  Stanislav Herwik,et al.  Brain-computer interfaces: an overview of the hardware to record neural signals from the cortex. , 2009, Progress in brain research.

[5]  Patrick D. Wolf,et al.  Evaluation of spike-detection algorithms fora brain-machine interface application , 2004, IEEE Transactions on Biomedical Engineering.

[6]  D. Kipke,et al.  Long-term neural recording characteristics of wire microelectrode arrays implanted in cerebral cortex. , 1999, Brain research. Brain research protocols.

[7]  Henrik Jörntell,et al.  Implant Size and Fixation Mode Strongly Influence Tissue Reactions in the CNS , 2011, PloS one.

[8]  E. Valderrama,et al.  Polyimide cuff electrodes for peripheral nerve stimulation , 2000, Journal of Neuroscience Methods.

[9]  Jens Schouenborg,et al.  Nociceptive C fibre input to the primary somatosensory cortex (SI). A field potential study in the rat , 1993, Brain Research.

[10]  B. Shyu,et al.  Intracortical circuits in rat anterior cingulate cortex are activated by nociceptive inputs mediated by medial thalamus. , 2006, Journal of neurophysiology.

[11]  L. Wallman,et al.  A polymer based electrode array for recordings in the cerebellum , 2011, 2011 5th International IEEE/EMBS Conference on Neural Engineering.

[12]  W. Reichert,et al.  Polyimides as biomaterials: preliminary biocompatibility testing. , 1993, Biomaterials.

[13]  J. Schouenborg,et al.  Nociceptive Transmission to Rat Primary Somatosensory Cortex – Comparison of Sedative and Analgesic Effects , 2013, PloS one.

[14]  J. Schouenborg,et al.  Properties of an adult spinal sensorimotor circuit shaped through early postnatal experience. , 2004, Journal of neurophysiology.

[15]  Dorielle T. Price,et al.  Effect of electrode geometry on the impedance evaluation of tissue and cell culture , 2007 .

[16]  P. Renaud,et al.  Demonstration of cortical recording using novel flexible polymer neural probes , 2008 .

[17]  J. Fawcett,et al.  Assessment of the biocompatibility of photosensitive polyimide for implantable medical device use. , 2009, Journal of biomedical materials research. Part A.

[18]  D. Kipke,et al.  Neural probe design for reduced tissue encapsulation in CNS. , 2007, Biomaterials.

[19]  Jiping He,et al.  Polyimide-based intracortical neural implant with improved structural stiffness , 2004 .

[20]  A. Ainsworth,et al.  Glass-coated platinum-plated tungsten microelectrodes , 1972, Medical and biological engineering.

[21]  Herbert Reichl,et al.  A comparison of thin film polymers for Wafer Level Packaging , 2010, 2010 Proceedings 60th Electronic Components and Technology Conference (ECTC).

[22]  F. Bereksi-Reguig,et al.  Wavelet denoising of the electrocardiogram signal based on the corrupted noise estimation , 2005, Computers in Cardiology, 2005.

[23]  Robert Puers,et al.  Determining the Young's modulus and creep effects in three different photo definable epoxies for MEMS applications , 2009 .

[24]  Justin C. Williams,et al.  Flexible polyimide-based intracortical electrode arrays with bioactive capability , 2001, IEEE Transactions on Biomedical Engineering.

[25]  R. Feng,et al.  Influence of processing conditions on the thermal and mechanical properties of SU8 negative photoresist coatings , 2002 .

[26]  K D Wise,et al.  Microfabrication techniques for integrated sensors and microsystems. , 1991, Science.

[27]  P T McCarthy,et al.  Simultaneous recording of rat auditory cortex and thalamus via a titanium-based, microfabricated, microelectrode device , 2011, Journal of neural engineering.

[28]  Khalil Najafi,et al.  New class of chronic recording multichannel neural probes with post-implant self-deployed satellite recording sites , 2011, 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference.

[29]  S. J. Kim,et al.  Biocompatibility of polyimide microelectrode array for retinal stimulation , 2004 .

[30]  J Schouenborg,et al.  Flexible multi electrode brain-machine interface for recording in the cerebellum , 2009, 2009 Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[31]  Shigeto Furukawa,et al.  Photosensitive-polyimide based method for fabricating various neural electrode architectures , 2012, Front. Neuroeng..

[32]  R. Quian Quiroga,et al.  Unsupervised Spike Detection and Sorting with Wavelets and Superparamagnetic Clustering , 2004, Neural Computation.

[33]  K. Djupsund,et al.  Flexible polyimide microelectrode array for in vivo recordings and current source density analysis. , 2007, Biosensors & bioelectronics.

[34]  Ken Yoshida,et al.  Assessment of Biocompatibility of Chronically Implanted Polyimide and Platinum Intrafascicular Electrodes , 2007, IEEE Transactions on Biomedical Engineering.

[35]  X. Navarro,et al.  Evaluation of polyimide as substrate material for electrodes to interface the peripheral nervous system , 2011, 2011 5th International IEEE/EMBS Conference on Neural Engineering.

[36]  David Chapman,et al.  Random signals and noise , 1992 .

[37]  I. Johnstone,et al.  Ideal spatial adaptation by wavelet shrinkage , 1994 .