Use of 3D bioprinting in biomedical engineering for clinical application

Tissue engineering is a widely developing scientific field, which combines technological solutions with the biology of the living organism. Regenerative medicine that uses tools of tissue engineering offers alternative means of therapy enhancing damaged tissues or organs. One of the development directions of contemporary chemical engineering is the scientific description of novel technologies that will enable production of porous structures – with high utility for biomedical engineering. 3D printing is one of the most popular methods used to produce scaffolds for cell culture. Nowadays a research team, in which authors are currently working, is dealing with the problem of manufacturing 3D constructs that play the role of artificial organ, obtained via 3D bioprinting. In the current article we present the possibilities and limitations of 3D bioprinting method in the context of possible application of manufactured structures as fully functional organs.

[1]  R. Hamman,et al.  Projections of Type 1 and Type 2 Diabetes Burden in the U.S. Population Aged <20 Years Through 2050 , 2012, Diabetes Care.

[2]  P. de Vos,et al.  Selection of polymers for application in scaffolds applicable for human pancreatic islet transplantation , 2016, Biomedical materials.

[3]  Guang Yang,et al.  Bioprinting and its applications in tissue engineering and regenerative medicine. , 2018, International journal of biological macromolecules.

[4]  Ibrahim T. Ozbolat,et al.  Bioprinting scale-up tissue and organ constructs for transplantation. , 2015, Trends in biotechnology.

[5]  M. Trucco,et al.  Endoscopic Gastric Submucosal Transplantation of Islets (ENDO‐STI): Technique and Initial Results in Diabetic Pigs , 2009, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[6]  Wei Zhu,et al.  Direct 3D bioprinting of prevascularized tissue constructs with complex microarchitecture. , 2017, Biomaterials.

[7]  Kang Zhang,et al.  3D printing of functional biomaterials for tissue engineering. , 2016, Current opinion in biotechnology.

[8]  J. Stockman,et al.  Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study , 2011 .

[9]  D Stamatialis,et al.  Fabrication of three-dimensional bioplotted hydrogel scaffolds for islets of Langerhans transplantation , 2015, Biofabrication.

[10]  A. Green,et al.  Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study , 2009, The Lancet.

[11]  Huifang Zhou,et al.  Recent advances in bioprinting techniques: approaches, applications and future prospects , 2016, Journal of Translational Medicine.

[12]  Bin Duan,et al.  State-of-the-Art Review of 3D Bioprinting for Cardiovascular Tissue Engineering , 2016, Annals of Biomedical Engineering.

[13]  Bethany C Gross,et al.  Evaluation of 3D printing and its potential impact on biotechnology and the chemical sciences. , 2014, Analytical chemistry.

[14]  Carl Schubert,et al.  Innovations in 3D printing: a 3D overview from optics to organs , 2013, British Journal of Ophthalmology.

[15]  C. L. Ventola Medical Applications for 3D Printing: Current and Projected Uses. , 2014, P & T : a peer-reviewed journal for formulary management.

[16]  Ibrahim T. Ozbolat,et al.  Bioprinting Technology: A Current State-of-the-Art Review , 2014 .

[17]  Matthew Di Prima,et al.  Additively manufactured medical products – the FDA perspective , 2016, 3D Printing in Medicine.

[18]  P. Zorlutuna,et al.  The Expanding World of Tissue Engineering: The Building Blocks and New Applications of Tissue Engineered Constructs , 2013, IEEE Reviews in Biomedical Engineering.