Con: pH-stat management of blood gases is preferable to alpha-stat in patients undergoing brain cooling for cardiac surgery.

[1]  J. Newburger,et al.  Relation of pH strategy and developmental outcome after hypothermic circulatory arrest. , 1993, The Journal of thoracic and cardiovascular surgery.

[2]  B. Hindman.  Cerebral physiology of hypothermia and hypothermic acid-base management during cardiopulmonary bypass , 1993, Cardiology in the Young.

[3]  M. Tsuji,et al.  Effects of pH on brain energetics after hypothermic circulatory arrest. , 1993, The Annals of thoracic surgery.

[4]  J. Mault,et al.  Cerebral metabolism and circulatory arrest: effects of duration and strategies for protection. , 1993, The Annals of thoracic surgery.

[5]  J. Lock,et al.  Factors Associated With Choreoathetosis After Cardiopulmonary Bypass in Children With Congenital Heart Disease , 1992, Circulation.

[6]  J. Mayer,et al.  Temperature monitoring during CPB in infants: does it predict efficient brain cooling? , 1992, The Annals of thoracic surgery.

[7]  H. Reimer,et al.  CEREBRAL METABOLISM DURING LOW-FLOW CARDIOPULMONARY BYPASS AND PROFOUND HYPOTHERMIC CIRCULATORY ARREST , 1992 .

[8]  W. Greeley,et al.  COMPARISON OF TWO STRATEGIES OF CPB COOLING OF JUGULAR VENOUS OXYGEN SATURATION , 1992 .

[9]  F. Burrows,et al.  Cerebral pressure-flow velocity relationship during hypothermic cardiopulmonary bypass in neonates and infants. , 1992, Anesthesia and analgesia.

[10]  R. Balaban,et al.  Low-flow hypothermic cardiopulmonary bypass protects the brain , 1991 .

[11]  B. Hindman,et al.  Differences in cerebral blood flow between alpha-stat and pH-stat management are eliminated during periods of decreased systemic flow and pressure. A study during cardiopulmonary bypass in rabbits. , 1991, Anesthesiology.

[12]  F. Burrows,et al.  Cerebral Hemodynamics in Neonates and Infants Undergoing Cardiopulmonary Bypass and Profound Hypothermic Circulatory Arrest: Assessment by Transcranial Doppler Sonography , 1991, Anesthesia and analgesia.

[13]  R. Balaban,et al.  Relationship of cerebral and myocardial intracellular pH to blood pH during hypothermia. , 1991, The American journal of physiology.

[14]  J. Mayer,et al.  Cognitive development of children following early repair of transposition of the great arteries using deep hypothermic circulatory arrest. , 1991, Pediatrics.

[15]  J G Reves,et al.  The effect of hypothermic cardiopulmonary bypass and total circulatory arrest on cerebral metabolism in neonates, infants, and children. , 1991, The Journal of thoracic and cardiovascular surgery.

[16]  W. White,et al.  Cerebral blood flow response to changes in arterial carbon dioxide tension during hypothermic cardiopulmonary bypass in children. , 1991, The Journal of thoracic and cardiovascular surgery.

[17]  H. Orita,et al.  Brain tissue pH, oxygen tension, and carbon dioxide tension in profoundly hypothermic cardiopulmonary bypass. Pulsatile assistance for circulatory arrest, low-flow perfusion, and moderate-flow perfusion. , 1990, The Journal of thoracic and cardiovascular surgery.

[18]  T. McDonald,et al.  Hemodynamics and metabolism during surface-induced hypothermia in the dog: a comparison of pH management strategies. , 1990, The Journal of surgical research.

[19]  G. Bashein,et al.  A randomized study of carbon dioxide management during hypothermic cardiopulmonary bypass. , 1990, Anesthesiology.

[20]  L. Smith,et al.  Effects of cardiopulmonary bypass on cerebral blood flow in neonates, infants, and children. , 1989, Circulation.

[21]  J. Tinker.  Cardiopulmonary Bypass: Current Concepts and Controversies , 1989 .

[22]  H. Orita,et al.  Brain tissue pH, oxygen tension, and carbon dioxide tension in profoundly hypothermic cardiopulmonary bypass. Comparative study of circulatory arrest, nonpulsatile low-flow perfusion, and pulsatile low-flow perfusion. , 1989, The Journal of thoracic and cardiovascular surgery.

[23]  T. Treasure,et al.  Cerebral blood flow determinants and their clinical implications during cardiopulmonary bypass , 1988 .

[24]  J. Pepper,et al.  CARBON DIOXIDE, BRAIN DAMAGE, AND CARDIAC SURGERY , 1988, The Lancet.

[25]  J. Pepper,et al.  EVIDENCE FOR INVOLVEMENT OF HYPOCAPNIA AND HYPOPERFUSION IN AETIOLOGY OF NEUROLOGICAL DEFICIT AFTER CARDIOPULMONARY BYPASS , 1987, The Lancet.

[26]  G. Guiraudon,et al.  Cerebral Autoregulation and Flow/Metabolism Coupling during Cardiopulmonary Bypass: The Influence of Paco2 , 1987, Anesthesia and analgesia.

[27]  H. Matsuda,et al.  Optimal perfusion flow rate for the brain during deep hypothermic cardiopulmonary bypass at 20 degrees C. An experimental study. , 1986, The Journal of thoracic and cardiovascular surgery.

[28]  L. Henriksen.  Brain Luxury Perfusion during Cardiopulmonary Bypass in Humans. A Study of the Cerebral Blood Flow Response to Changes in CO2, O2, and Blood Pressure , 1986, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[29]  P. Myerowitz,et al.  Ectothermic philosophy of acid-base balance to prevent fibrillation during hypothermia. , 1986, Archives of surgery.

[30]  S. Slogoff,et al.  Neuropsychiatric Complications after Cardiopulmonary Bypass: Cerebral Protection by a Barbiturate , 1985, Anesthesiology.

[31]  H. Rahn,et al.  Acid-Base Regulation and Body Temperature , 1985, Developments in Critical Care Medicine and Anesthesiology.

[32]  L. Smith,et al.  Factors and their influence on regional cerebral blood flow during nonpulsatile cardiopulmonary bypass. , 1984, The Annals of thoracic surgery.

[33]  B. Siesjö,et al.  Influence of in vitro Lactic Acidosis and Hypercapnia on Respiratory Activity of Isolated Rat Brain Mitochondria , 1984, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[34]  G. Renault,et al.  Performance of hypothermic isolated rat heart at various levels of blood acid-base status. , 1984, Journal of applied physiology: respiratory, environmental and exercise physiology.

[35]  E. Blackstone,et al.  Relationship of brain blood flow and oxygen consumption to perfusion flow rate during profoundly hypothermic cardiopulmonary bypass. An experimental study. , 1984, The Journal of thoracic and cardiovascular surgery.

[36]  H. Swan.  The importance of acid-base management for cardiac and cerebral preservation during open heart operations. , 1984, Surgery, gynecology & obstetrics.

[37]  R. M. Peters,et al.  The effect of pH on the hypothermic ventricular fibrillation threshold. , 1984, The Journal of thoracic and cardiovascular surgery.

[38]  P. Piot,et al.  SEROEPIDEMIOLOGY OF HANTAAN-RELATED VIRUS INFECTIONS IN BELGIAN POPULATIONS , 1983, The Lancet.

[39]  A. Keats,et al.  Etiologic Factors in Neuropsychiatric Complications Associated with Cardiopulmonary Bypass , 1982, Anesthesia and analgesia.

[40]  E. Blackstone,et al.  Relationship of whole body oxygen consumption to perfusion flow rate during hypothermic cardiopulmonary bypass. , 1982, The Journal of thoracic and cardiovascular surgery.

[41]  R. Iles.  Measurement of intracellular pH , 1981, Bioscience reports.

[42]  J. Ingwall,et al.  Hypothermic circulatory arrest: 31-phosphorus nuclear magnetic resonsance of isolated perfused neonatal rat brain. , 1979, The Journal of thoracic and cardiovascular surgery.

[43]  A. Castañeda,et al.  Cerebral anoxia: effect of deep hypothermia and pH. , 1979, Surgery.

[44]  M. Weisfeldt,et al.  Tight coupling of intracellular pH and ventricular performance , 1978 .

[45]  J. Williamson,et al.  Control of energy production in cardiac muscle: effects of ischemia in acidosis. , 1976, Recent advances in studies on cardiac structure and metabolism.

[46]  N. Lassen,et al.  The luxury-perfusion syndrome and its possible relation to acute metabolic acidosis localised within the brain. , 1966, Lancet.

[47]  B. Chance,et al.  Acid-linked functions of intermediates in oxidative phosphorylation. II. Experimental studies of the effect of pH upon respiratory, phosphorylative and transfer activities of liver and heart mitochondria. , 1959, The Journal of biological chemistry.