Detection of Epstein‐Barr virus DNA in American Burkitt's lymphoma

Twenty American patients with Burkitt's lymphoma (BL) were studied serologically and biochemically to detect an association with Epstein‐Barr virus (EBV). A wide range of antibody reactivities was encountered. Five patients had serorogical profiles similar to those of African patients with BL: one and possibly two of these patients harbored EBV‐DNA in their tumors. Fifteen patients had low or absent antibody to EBV: tumors from 10 of these patients lacked evidence of EBV‐DNA. An unexplained association between elevated antibody (≥1:80) to EBV virus capsid antigen (VCA) and a favorable prognosis was noted in this series; this prognostic observation requires further substantiation. Thus, it appears that EBV‐associated BL is inversely proportional to tumor endemicity. An etiological role for EBV in BL remains speculative.

[1]  P. Levine,et al.  Epstein-Barr virus in an American patient with Burkitt's lymphoma: detection of viral genome in tumor tissue and establishment of a tumor-derived cell line (NAB). , 1976, Journal of the National Cancer Institute.

[2]  G. Klein,et al.  Association of Epstein–Barr viral genomes with American Burkitt lymphoma , 1976, Nature.

[3]  G. Giunchi,et al.  Thymus transplantation. Reconstitution of cellular immunity in a four-year-old patient with T-cell deficiency. , 1975, Clinical and experimental immunology.

[4]  C. Rath,et al.  “B” cell origin of malignant cells in a case of american burkitt's lymphoma characterization of cells from a pleural effusion , 1975, Cancer.

[5]  V. Devita,et al.  The American Burkitt Lymphoma Registry: a progress report. , 1975, Annals of internal medicine.

[6]  H. Gralnick,et al.  American Burkitt's lymphoma: a clinicopathologic study of 30 cases. I. Clinical factors relating to prolonged survival. , 1975, The American journal of medicine.

[7]  G. Flandrin,et al.  Acute leukemia with Burkitt's tumor cells: A study of six cases with special reference to lymphocyte surface markers. , 1975, Blood.

[8]  G. Klein,et al.  Relationship between Epstein‐Barr virus (EBV) DNA and the EBV‐determined nuclear antigen (EBNA) in Burkitt lymphoma biopsies and other lymphoproliferative malignancies , 1974, International journal of cancer.

[9]  A. Bluming,et al.  Cell kinetics in Burkitt lymphoma. , 1974, European journal of cancer.

[10]  P. Levine,et al.  Absence of Epstein-Barr viral DNA in Amercian Burkitt's lymphoma. , 1973, The New England journal of medicine.

[11]  G. Klein,et al.  DNA of Epstein-Barr virus detected in tissue of Burkitt's lymphoma and nasopharyngeal carcinoma. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[12]  M. Epstein,et al.  Pilot experiments with EB virus in owl monkeys (aotus trivirgatus). I. Reticuloproliferative disease in an inoculated animal , 1973, International journal of cancer.

[13]  G. Miller,et al.  Malignant lymphoma in cottontop marmosets after inoculation with Epstein-Barr virus. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[14]  Y. Hirshaut,et al.  Epstein-Barr-virus antibodies in American and African Burkitt's lymphoma. , 1973, Lancet.

[15]  G. Klein,et al.  IMMUNOGLOBULIN AND GLUCOSE-6-PHOSPHATE DEHYDROGENASE AS MARKERS OF CELLULAR ORIGIN IN BURKITT LYMPHOMA , 1973, The Journal of experimental medicine.

[16]  G. Klein,et al.  Cellular localization of an Epstein‐Barr virus (EBV)‐associated complement‐fixing antigen in producer and non‐producer lymphoblastoid cell lines , 1973, International journal of cancer.

[17]  G. Klein,et al.  Patterns of antibodies to Epstein-Barr virus-induced early antigens in Burkitt's lymphoma. Comparison of dying patients with long-term survivors. , 1973, Journal of the National Cancer Institute.

[18]  P. Levine,et al.  Antibodies to epstein‐barr virus (EBV) in American patients with Burkitt's lymphoma , 1972, Cancer.

[19]  A. Bluming,et al.  Relapse patterns in Burkitt's lymphoma. , 1972, Cancer research.

[20]  G. Klein,et al.  Demonstration of two distinct components in the early antigen complex of epstein‐barr virus‐infected cells , 1971, International journal of cancer.

[21]  G. Klein,et al.  Epstein–Barr Virus in Burkitt's Lymphoma and Nasopharyngeal Carcinoma: EBV DNA in Biopsies of Burkitt Tumours and Anaplastic Carcinomas of the Nasopharynx , 1970, Nature.

[22]  W. Henle,et al.  Observations on childhood infections with the Epstein-Barr virus. , 1970, The Journal of infectious diseases.

[23]  W. Henle,et al.  Surface marker characteristics and Epstein-Barr virus studies of two established North American Burkitt's lymphoma cell lines. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[24]  G. Klein.  Studies on the Epstein-Barr Virus genome and the EBV-determined nuclear antigen in human malignant disease. , 1975, Cold Spring Harbor symposia on quantitative biology.

[25]  G. Klein,et al.  Epstein-Barr virus (EBV)-associated antibody patterns in relation to the deficiency of cell-mediated immunity in patients with Hodgkin's disease. , 1975, IARC scientific publications.