N-nitrosodiethylamine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced morphological transformation of C3H/10T1/2CL8 cells expressing human cytochrome P450 2A6.

[1]  F. Gonzalez,et al.  Retroviral mediated expression of human cytochrome P450 2A6 in C3H/10T1/2 cells confers transformability by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). , 1993, Carcinogenesis.

[2]  R. Langenbach,et al.  Recombinant DNA approaches for the development of metabolic systems used in in vitro toxicology. , 1992, Mutation research.

[3]  F. Guengerich,et al.  Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human lung and liver microsomes and cytochromes P-450 expressed in hepatoma cells. , 1992, Cancer research.

[4]  K. Kaya,et al.  N-Nitroso Compounds in the Environment , 1992 .

[5]  C. S. Yang,et al.  Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by cytochrome P450IIB1 in a reconstituted system. , 1991, Carcinogenesis.

[6]  S. Nesnow,et al.  Morphological transformation and DNA adduct formation by benz[j]aceanthrylene and its metabolites in C3H10T1/2CL8 cells: evidence for both cyclopenta-ring and bay-region metabolic activation pathways. , 1991, Cancer research.

[7]  S. Amin,et al.  Tumorigenicity of the tobacco-specific carcinogen 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone in infant mice. , 1991, Cancer letters.

[8]  F. Gonzalez,et al.  A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6. , 1991, Carcinogenesis.

[9]  C. Jefcoate,et al.  Purification and immunological characterization of a novel cytochrome P450 from C3H/10T1/2 cells. , 1991, Archives of biochemistry and biophysics.

[10]  N. Dean,et al.  Okadaic acid inhibits PDGF-induced proliferation and decreases PDGF receptor number in C3H/10T1/2 mouse fibroblasts. , 1991, Carcinogenesis.

[11]  F. Gonzalez,et al.  DNA-expressed human cytochrome P450s: a new age of molecular toxicology and human risk assessment. , 1991, Mutation research.

[12]  M. P. Arlotto,et al.  Human cytochrome P450IIA3: cDNA sequence role of the enzyme in the metabolic of promutagens comparison to nitrosamine activation by human cytochrome P450IIE1 , 1990 .

[13]  F. Gonzalez,et al.  The CYP2A3 gene product catalyzes coumarin 7-hydroxylation in human liver microsomes. , 1990, Biochemistry.

[14]  P. Billings,et al.  Inhibition of radiation-induced transformation of C3H/10T1/2 cells by specific protease substrates. , 1990, Carcinogenesis.

[15]  C. Jefcoate,et al.  Characterization of a novel cytochrome P450 from the transformable cell line, C3H/10T1/2. , 1990, Carcinogenesis.

[16]  S. Nesnow,et al.  DNA adduct formation, metabolism, and morphological transforming activity of aceanthrylene in C3H10T1/2CL8 cells. , 1989, Mutation research.

[17]  Yao-Tseng Chen,et al.  Transfection of a human cytochrome P-450 gene into the human lymphoblastoid cell line, AHH-1, and use of the recombinant cell line in gene mutation assays. , 1989, Carcinogenesis.

[18]  M. Wolfson,et al.  Partial down-regulation of protein kinase C in C3H 10T 1/2 mouse fibroblasts transfected with the human Ha-ras oncogene. , 1988, Cancer research.

[19]  S. Hecht,et al.  Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke. , 1988, Carcinogenesis.

[20]  M. Gingras,et al.  Natural killer cell regulation of implantation and early lung growth of H-ras-transformed 10T1/2 fibroblasts in mice. , 1987, Cancer research.

[21]  R. E. Kouri,et al.  A method for the amplification of chemically induced transformation in C3H/10T1/2 clone 8 cells: its use as a potential screening assay. , 1987, Journal of the National Cancer Institute.

[22]  W. Trimble,et al.  Morphological transformation and tumorigenicity in C3H/10T1/2 cells transformed with an inducible c-Ha-ras oncogene , 1987, Bioscience reports.

[23]  V. Sorrentino,et al.  Increased radiation-induced transformation in C3H/10T1/2 cells after transfer of an exogenous c-myc gene. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[24]  B. Krolewski,et al.  Effect of aliphatic amides on oncogenic transformation, sister chromatid exchanges, and mutations induced by cyclopenta[cd]-pyrene and benzo[a]pyrene. , 1986, Carcinogenesis.

[25]  W. E. Fahl,et al.  Integration of a mutant c-Ha-ras oncogene into C3H/10T1/2 cells and its relationship to tumorigenic transformation. , 1985, Carcinogenesis.

[26]  F. A. van der Hoorn,et al.  Differential transformation of C3H10T1/2 cells by v-mos: sequential expression of transformation parameters , 1985, Molecular and cellular biology.

[27]  I. Weinstein,et al.  Oncogene-induced transformation of C3H 10T1/2 cells is enhanced by tumor promoters. , 1984, Science.

[28]  P. Breen,et al.  Comparison of primary hepatocytes and S9 metabolic activation systems for the C3H-10T 1/2 cell transformation assay. , 1984, Carcinogenesis.

[29]  D. Baltimore,et al.  Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus , 1983, Cell.

[30]  B. Casto,et al.  Cell transformation by chemical agents--a review and analysis of the literature. A report of the U.S. Environmental Protection Agency Gene-Tox Program. , 1983, Mutation research.

[31]  S. Hecht,et al.  Comparative carcinogenicity in A/J mice and metabolism by cultured mouse peripheral lung of N'-nitrosonornicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, and their analogues. , 1983, Cancer research.

[32]  C. Heidelberger,et al.  Induction of cytotoxicity, mutation, cytogenetic changes, and neoplastic transformation by benzo(a)pyrene and derivatives in C3H/10T1/2 clone 8 mouse fibroblasts. , 1982, Cancer research.

[33]  S. Nesnow,et al.  Identification of cocarcinogens and their potential mechanisms of action using C3H10T 1/2 CL8 mouse embryo fibroblasts. , 1981, Cancer research.

[34]  R. L. Carter,et al.  IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans , 1980, IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans.

[35]  C. Heidelberger,et al.  The metabolism of benzo(alpha)pyrene by cytochrome P-450 in transformable and nontransformable C3H mouse fibroblasts. , 1979, The Journal of biological chemistry.

[36]  A Poland,et al.  An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin. , 1978, The Journal of pharmacology and experimental therapeutics.

[37]  J. Bertram.  Effects of serum concentration on the expression of carcinogen-induced transformation in the C3H/10T1/2 CL8 cell line. , 1977, Cancer research.

[38]  C. Heidelberger,et al.  Two-stage chemical oncogenesis in cultures of C3H/10T1/2 cells. , 1976, Cancer research.

[39]  S. Nesnow,et al.  The effect of modifiers of microsomal enzymes on chemical oncogenesis in cultures of C3H mouse cell lines. , 1976, Cancer research.

[40]  C. Heidelberger,et al.  Quantitative and qualitative studies of chemical transformation of cloned C3H mouse embryo cells sensitive to postconfluence inhibition of cell division. , 1973, Cancer research.

[41]  C. Heidelberger,et al.  Establishment and characterization of a cloned line of C3H mouse embryo cells sensitive to postconfluence inhibition of division. , 1973, Cancer research.

[42]  S. Nesnow,et al.  Transfection of cytochrome P450 cDNAs into mammalian cells used in mutation and transformation assays. , 1990, Progress in clinical and biological research.

[43]  S. Nesnow,et al.  Transfection of a Rat Cytochrome P450b cDNA Into C3H10T1/2CL8 Mouse Embryo Fibroblasts , 1989, Molecular carcinogenesis.

[44]  S Nesnow,et al.  Quantitative analysis of the metabolism of benzo(a)pyrene by transformable C3H10T1/2CL8 mouse embryo fibroblasts. , 1986, Teratogenesis, carcinogenesis, and mutagenesis.

[45]  C. Heidelberger,et al.  S-9 metabolic activation enhances aflatoxin-mediated transformation of C3H/10T1/2 cells. , 1985, Toxicology and applied pharmacology.

[46]  R. Langenbach,et al.  The Use of Intact Cellular Activation Systems in Genetic Toxicology Assays , 1983 .

[47]  Y. Oshiro,et al.  Morphological transformation of C3H/10T1/2 CL8 cells by procarcinogens. , 1982, Environmental mutagenesis.

[48]  S Nesnow,et al.  Improved transformation of C3H10T1/2CL8 cells by direct- and indirect-acting carcinogens. , 1982, Carcinogenesis.