Skin peeling syndrome in a Kurdish family.

Skin peeling syndrome (SPS) is a rare genodermatosis, with variable age of onset from birth1to adulthood.2Clinically, it is characterized by a pruritic or nonpruritic spontaneous superficial peeling of the skin, which sometimes is accompanied by erythema or vesiculation.2The skin involvement is usually general, but in some patients the scalp, face, palms, and soles may be unaffected.2Seasonal changes have been reported.2,3The histologic picture is characterized by separation of the epidermis between the stratum corneum and the stratum granulosum.3We describe herein two siblings of a Jewish family originating from Kurdistan who were affected by SPS. Report of Cases Case 1.— The proband, an 8-year-old boy, was referred to the skin clinic for itching, redness, and peeling of the skin. Redness, peeling of the neck, antecubital and popliteal areas, and wrists, developed four days after his birth; later on, redness and peeling