CD4 cell recovery during successful antiretroviral therapy in naive HIV-infected patients: the role of intravenous drug use

We evaluated the impact of HIV risk practice on immune reconstitution in a prospective cohort of 288 patients (176 former injecting drug users) who maintained complete virus suppression for more than 24 months. Significant differences in CD4 cell counts at 6 and 24 months were detected. Multivariate analysis showed that drug use was an independent predictor of poor immunological recovery. Injection drug abuse impairs short and long-term CD4 cell recovery in HIV-positive patients initiating successful highly active antiretroviral therapy.

[1]  A. Mocroft,et al.  Decline in the AIDS and death rates in the EuroSIDA study: an observational study , 2003, The Lancet.

[2]  S. Moreno,et al.  Long-term outcomes among antiretroviral-naive human immunodeficiency virus-infected patients with small increases in CD4+ cell counts after successful virologic suppression. , 2002, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[3]  M. Roth,et al.  Cocaine enhances human immunodeficiency virus replication in a model of severe combined immunodeficient mice implanted with human peripheral blood leukocytes. , 2002, The Journal of infectious diseases.

[4]  M. Kazatchkine,et al.  Long-term clinical outcome of human immunodeficiency virus-infected patients with discordant immunologic and virologic responses to a protease inhibitor-containing regimen. , 2001, The Journal of infectious diseases.

[5]  M. Battegay,et al.  Clinical progression, survival, and immune recovery during antiretroviral therapy in patients with HIV-1 and hepatitis C virus coinfection: the Swiss HIV Cohort Study , 2000, The Lancet.

[6]  S. Mahajan,et al.  Cocaine Differentially Modulates Chemokine Production by Mononuclear Cells from Normal Donors and Human Immunodeficiency Virus Type 1-Infected Patients , 2000, Clinical Diagnostic Laboratory Immunology.

[7]  J V Giorgi,et al.  Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. , 1999, The Journal of infectious diseases.

[8]  F. Chiappelli,et al.  Cocaine blunts human CD4+ cell activation. , 1994, Immunopharmacology.

[9]  O. Bagasra,et al.  Human immunodeficiency virus type 1 replication in peripheral blood mononuclear cells in the presence of cocaine. , 1993, The Journal of infectious diseases.

[10]  H. Balfour,et al.  Cocaine potentiates HIV-1 replication in human peripheral blood mononuclear cell cocultures. Involvement of transforming growth factor-beta. , 1991, Journal of immunology.