Mouse Models of Negative Selection

[1]  Michelle M. Sandau,et al.  The timing of TCRα expression critically influences T cell development and selection , 2005, The Journal of experimental medicine.

[2]  T. Nomura,et al.  Development of Autoimmunity against Transcriptionally Unrepressed Target Antigen in the Thymus of Aire-Deficient Mice1 , 2005, The Journal of Immunology.

[3]  Susan R. Wilson,et al.  Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim. , 2004, Immunity.

[4]  Michael J. Bevan,et al.  Central Tolerance to Tissue-specific Antigens Mediated by Direct and Indirect Antigen Presentation , 2004, The Journal of experimental medicine.

[5]  T. Brocker,et al.  The Role of Dendritic Cells in Selection of Classical and Nonclassical CD8+ T Cells In Vivo1 , 2004, The Journal of Immunology.

[6]  E. Palmer,et al.  T cell division and death are segregated by mutation of TCRbeta chain constant domains. , 2004, Immunity.

[7]  C. Choisy-Rossi,et al.  Enhanced Pathogenicity of Diabetogenic T Cells Escaping a Non-MHC Gene-Controlled Near Death Experience1 , 2004, The Journal of Immunology.

[8]  D. Gray,et al.  CCR7 Signals Are Essential for Cortex–Medulla Migration of Developing Thymocytes , 2004, The Journal of experimental medicine.

[9]  A. Strasser,et al.  Negative selection of semimature CD4(+)8(-)HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[10]  C. Benoist,et al.  Good riddance: Thymocyte clonal deletion prevents autoimmunity. , 2004, Current opinion in immunology.

[11]  P. Allen,et al.  Massive Thymic Deletion Results in Systemic Autoimmunity through Elimination of CD4+ CD25+ T Regulatory Cells , 2004, The Journal of experimental medicine.

[12]  N. Shimizu,et al.  AIRE Functions As an E3 Ubiquitin Ligase , 2004, The Journal of experimental medicine.

[13]  Alison R. Perate,et al.  Alloreactive CD4 T Cell Activation In Vivo: An Autonomous Function of the Indirect Pathway of Alloantigen Presentation1 , 2003, The Journal of Immunology.

[14]  Timothy K Starr,et al.  Positive and negative selection of T cells. , 2003, Annual review of immunology.

[15]  K. Hogquist,et al.  The Central Tolerance Response to Male Antigen in Normal Mice Is Deletion and Not Receptor Editing 1 , 2003, The Journal of Immunology.

[16]  E. Reinherz,et al.  Gene expression analysis of thymocyte selection in vivo. , 2003, International immunology.

[17]  A. Strasser,et al.  Normal Thymocyte Negative Selection in TRAIL-deficient Mice , 2003, The Journal of experimental medicine.

[18]  Sheryl K Elkin,et al.  A Role for the B7-1/B7-2:CD28/CTLA-4 Pathway During Negative Selection1 , 2003, The Journal of Immunology.

[19]  E. Wawrousek,et al.  T Cell Tolerance to a Neo-Self Antigen Expressed by Thymic Epithelial Cells: The Soluble Form Is More Effective Than the Membrane-Bound Form , 2003, The Journal of Immunology.

[20]  Denis Bouchard,et al.  Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity. , 2003, Genes & development.

[21]  J. White,et al.  A Threshold for Central T Cell Tolerance to an Inducible Serum Protein1 , 2003, The Journal of Immunology.

[22]  O. Michielin,et al.  CD3δ Establishes a Functional Link between the T Cell Receptor and CD8* , 2003, The Journal of Biological Chemistry.

[23]  A. Lew,et al.  Without peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activation , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[24]  Mark S. Anderson,et al.  Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein , 2002, Science.

[25]  A. Michie,et al.  Regulation of thymocyte differentiation: pre-TCR signals and beta-selection. , 2002, Seminars in immunology.

[26]  W. Zong,et al.  Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis , 2002, Nature Immunology.

[27]  H. Mcdevitt,et al.  CD4+ T Cells from Glutamic Acid Decarboxylase (GAD)65-specific T Cell Receptor Transgenic Mice Are Not Diabetogenic and Can Delay Diabetes Transfer , 2002, The Journal of experimental medicine.

[28]  J. Brewer,et al.  Thymocyte Apoptosis Induced by T Cell Activation Is Mediated by Glucocorticoids In Vivo1 , 2002, The Journal of Immunology.

[29]  S. Jameson,et al.  A Spontaneous CD8 T Cell-Dependent Autoimmune Disease to an Antigen Expressed Under the Human Keratin 14 Promoter1 , 2002, The Journal of Immunology.

[30]  T. Tadakuma,et al.  Different Role of Apaf‐1 in Positive Selection, Negative Selection and Death by Neglect in Foetal Thymic Organ Culture , 2002, Scandinavian journal of immunology.

[31]  B. Sullivan,et al.  Positive selection of a Qa-1-restricted T cell receptor with specificity for insulin. , 2002, Immunity.

[32]  H. Kessels,et al.  Contributions of the T Cell Receptor–associated CD3γ–ITAM to Thymocyte Selection , 2002, The Journal of experimental medicine.

[33]  E. Reinherz,et al.  Involvement of the TCR Cβ FG Loop in Thymic Selection and T Cell Function , 2002, The Journal of experimental medicine.

[34]  C. Janeway,et al.  Negative selection of thymocytes expressing the D10 TCR , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[35]  J. Miyazaki,et al.  Generation of CD4+CD25+ Regulatory T Cells from Autoreactive T Cells Simultaneously with Their Negative Selection in the Thymus and from Nonautoreactive T Cells by Endogenous TCR Expression1 , 2002, The Journal of Immunology.

[36]  Yang Liu,et al.  Perinatal Blockade of B7-1 and B7-2 Inhibits Clonal Deletion of Highly Pathogenic Autoreactive T Cells , 2002, The Journal of experimental medicine.

[37]  T. Fujisawa,et al.  Predominant Role of T Cell Receptor (TCR)-α Chain in Forming Preimmune TCR Repertoire Revealed by Clonal TCR Reconstitution System , 2002, The Journal of experimental medicine.

[38]  R. Hodes,et al.  CD40 Ligand Functions Non-Cell Autonomously to Promote Deletion of Self-Reactive Thymocytes , 2002, The Journal of Immunology.

[39]  T. Mak,et al.  The Apoptotic Protease-Activating Factor 1-Mediated Pathway of Apoptosis Is Dispensable for Negative Selection of Thymocytes1 , 2002, The Journal of Immunology.

[40]  E. Reinherz,et al.  Peptide-Induced Negative Selection of Thymocytes Activates Transcription of an NF-ΚB Inhibitor , 2002 .

[41]  M. Jenkins,et al.  Tracking salmonella-specific CD4 T cells in vivo reveals a local mucosal response to a disseminated infection. , 2002, Immunity.

[42]  A. Strasser,et al.  BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes , 2002, Nature.

[43]  C. Janeway,et al.  Dual receptor T cells extend the immune repertoire for foreign antigens , 2002, Nature Immunology.

[44]  L. Klein,et al.  Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self , 2001, Nature Immunology.

[45]  D. M. Page,et al.  Requirement for a Complex Array of Costimulators in the Negative Selection of Autoreactive Thymocytes In Vivo1 , 2001, The Journal of Immunology.

[46]  A. Thern,et al.  DR3 Regulates Negative Selection during Thymocyte Development , 2001, Molecular and Cellular Biology.

[47]  J. Goverman,et al.  Age-dependent T cell tolerance and autoimmunity to myelin basic protein. , 2001, Immunity.

[48]  A. Naji,et al.  Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide , 2001, Nature Immunology.

[49]  H. Macdonald,et al.  Dissociation of thymic positive and negative selection in transgenic mice expressing major histocompatibility complex class I molecules exclusively on thymic cortical epithelial cells. , 2001, Blood.

[50]  E. Wagner,et al.  C-Jun Nh2-Terminal Kinase (Jnk)1 and Jnk2 Have Similar and Stage-Dependent Roles in Regulating T Cell Apoptosis and Proliferation , 2001, The Journal of experimental medicine.

[51]  C. Janeway,et al.  On the Self-Referential Nature of Naive MHC Class II-Restricted T Cells1 , 2000, The Journal of Immunology.

[52]  Kristin A. Hogquist,et al.  Receptor editing in developing T cells , 2000, Nature Immunology.

[53]  J. Stone,et al.  RasGRP is essential for mouse thymocyte differentiation and TCR signaling , 2000, Nature Immunology.

[54]  P. Love,et al.  Function of Cd3ε-Mediated Signals in T Cell Development , 2000, The Journal of experimental medicine.

[55]  E. Palmer,et al.  Normal Thymic Architecture and Negative Selection Are Associated with Aire Expression, the Gene Defective in the Autoimmune-Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED)1 , 2000, The Journal of Immunology.

[56]  Barbara Hausmann,et al.  A motif in the αβ T-cell receptor controls positive selection by modulating ERK activity , 2000, Nature.

[57]  A. Rudensky,et al.  Competition for Specific Intrathymic Ligands Limits Positive Selection in a TCR Transgenic Model of CD4+ T Cell Development1 , 2000, The Journal of Immunology.

[58]  S. Antonarakis,et al.  The Autoimmune Regulator Protein Has Transcriptional Transactivating Properties and Interacts with the Common Coactivator CREB-binding Protein* , 2000, The Journal of Biological Chemistry.

[59]  C. Janeway,et al.  Functional and Phenotypic Evidence for Presentation of Eα52–68 Structurally Related Self-Peptide(s) in I-Eα-Deficient Mice1 , 2000, The Journal of Immunology.

[60]  R. Perlmutter,et al.  Caspase Enzyme Activity Is Not Essential for Apoptosis During Thymocyte Development1 , 2000, The Journal of Immunology.

[61]  L. McHeyzer-Williams,et al.  Antigen-driven selection of TCR In vivo: related TCR alpha-chains pair with diverse TCR beta-chains. , 1999, Journal of immunology.

[62]  A. Strasser,et al.  Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity. , 1999, Science.

[63]  T. Chun,et al.  The Majority of H2-M3 Is Retained Intracellularly in a Peptide-Receptive State and Traffics to the Cell Surface in the Presence of N-Formylated Peptides , 1999, The Journal of experimental medicine.

[64]  J. Altman,et al.  Negative selection of T cells occurs throughout thymic development. , 1999, Journal of immunology.

[65]  U. Staerz,et al.  Positive selection of an H2-M3 restricted T cell receptor. , 1999, Immunity.

[66]  Yang Liu,et al.  Cytotoxic T Lymphocytes to An Unmutated Tumor Rejection Antigen P1A: Normal Development but Restrained Effector Function In Vivo , 1999, The Journal of experimental medicine.

[67]  K. Hogquist,et al.  Antigen-induced coreceptor down-regulation on thymocytes is not a result of apoptosis. , 1999, Journal of immunology.

[68]  B. Lucas,et al.  Timing and casting for actors of thymic negative selection. , 1999, Journal of immunology.

[69]  Mark M. Davis,et al.  The Avidity Spectrum of  T Cell Receptor Interactions Accounts for T Cell Anergy in a Double Transgenic Model , 1999, The Journal of experimental medicine.

[70]  C. Martínez-A,et al.  Blocked negative selection of developing T cells in mice expressing the baculovirus p35 caspase inhibitor , 1999, The EMBO journal.

[71]  R. Flavell,et al.  The JNK Pathway Regulates the In Vivo Deletion of Immature CD4+CD8+ Thymocytes , 1998, The Journal of experimental medicine.

[72]  S. Jameson,et al.  Preselection Thymocytes Are More Sensitive to T Cell Receptor Stimulation Than Mature T Cells , 1998, The Journal of experimental medicine.

[73]  Li Wu,et al.  The linkage between T‐cell and dendritic cell development in the mouse thymus , 1998, Immunological reviews.

[74]  A. Kruisbeek,et al.  Thymocyte selection: not by TCR alone , 1998, Immunological reviews.

[75]  L. Peltonen,et al.  Gene defect behind APECED: a new clue to autoimmunity. , 1998, Human molecular genetics.

[76]  E. Palmer,et al.  Positive Selection Through a Motif in the αβ T Cell Receptor , 1998 .

[77]  Keisuke Kuida,et al.  Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9 , 1998, Cell.

[78]  P. Allen,et al.  TCR Transgenic Mice in Which Usage of Transgenic α- and β-Chains Is Highly Dependent on the Level of Selecting Ligand , 1998, The Journal of Immunology.

[79]  L. Klein,et al.  CD4 T Cell Tolerance to Human C-reactive Protein, an Inducible Serum Protein, Is Mediated by Medullary Thymic Epithelium , 1998, The Journal of experimental medicine.

[80]  G. Anderson,et al.  Use of explant technology in the study of in vitro immune responses. , 1998, Journal of immunological methods.

[81]  J. Sprent,et al.  A Role for Fas in Negative Selection of Thymocytes In Vivo , 1998, The Journal of experimental medicine.

[82]  H. von Boehmer,et al.  Allelic Inclusion of T Cell Receptor α Genes Poses an Autoimmune Hazard Due to Low-Level Expression of Autospecific Receptors , 1998 .

[83]  Kenneth G. C. Smith,et al.  A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes , 1998, The EMBO journal.

[84]  Kevin E. Swier,et al.  Control of Leishmania major by a monoclonal alpha beta T cell repertoire. , 1998, Journal of immunology.

[85]  S. Hedrick,et al.  TNF receptor-deficient mice reveal striking differences between several models of thymocyte negative selection. , 1998, Journal of immunology.

[86]  R. Zinkernagel,et al.  Virus‐specific major MHC class II‐restricted TCR‐transgenic mice: effects on humoral and cellular immune responses after viral infection , 1998, European journal of immunology.

[87]  P. Marrack,et al.  Selection of Antigen-specific T Cells by a Single IEk Peptide Combination , 1997, The Journal of experimental medicine.

[88]  P. Santamaria,et al.  A Mechanism for the Major Histocompatibility Complex–linked Resistance to Autoimmunity , 1997, The Journal of experimental medicine.

[89]  M. Bevan,et al.  Antigen‐specific and nonspecific deletion of immature cortical thymocytes caused by antigen injection , 1997, European journal of immunology.

[90]  E. Reinherz,et al.  Double‐positive T cell receptorhigh thymocytes are resistant to peptide/major histocompatibility complex ligand‐induced negative selection , 1997, European journal of immunology.

[91]  A. Rudensky,et al.  Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides. , 1997, Immunity.

[92]  F. Chan,et al.  Functional redundancy of the Nur77 and Nor‐1 orphan steroid receptors in T‐cell apoptosis , 1997, The EMBO journal.

[93]  A. Grinberg,et al.  Role of the Multiple T Cell Receptor (TCR)-ζ Chain Signaling Motifs in Selection of the T Cell Repertoire , 1997, The Journal of experimental medicine.

[94]  M. Riedinger,et al.  Targeted Expression of Major Histocompatibility Complex (MHC) Class II Molecules Demonstrates that Dendritic Cells Can Induce Negative but Not Positive Selection of Thymocytes In Vivo , 1997, The Journal of experimental medicine.

[95]  C. Bona,et al.  Conditions That Induce Tolerance in Mature CD4+ T Cells , 1997, The Journal of experimental medicine.

[96]  P. Finn,et al.  Fas modulation of apoptosis during negative selection of thymocytes. , 1996, Immunity.

[97]  V. Kouskoff,et al.  Organ-Specific Disease Provoked by Systemic Autoimmunity , 1996, Cell.

[98]  Keisuke Kuida,et al.  Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice , 1996, Nature.

[99]  P. Marrack,et al.  Thymocytes can become mature T cells without passing through the CD4+ CD8+, double-positive stage , 1996, The Journal of experimental medicine.

[100]  D. Kioussis,et al.  Direct visualization of thymocyte apoptosis in neglect, acute and steady-state negative selection. , 1996, International immunology.

[101]  L. Glimcher,et al.  Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex , 1996, Nature.

[102]  P. Marrack,et al.  The responses of mature T cells are not necessarily antagonized by their positively selecting peptide. , 1996, Journal of immunology.

[103]  S. Jameson,et al.  T-cell-receptor affinity and thymocyte positive selection , 1996, Nature.

[104]  Y. Xia,et al.  Antigen compartmentation and T helper cell tolerance induction , 1996, The Journal of experimental medicine.

[105]  D. Fremont,et al.  Structures of an MHC Class II Molecule with Covalently Bound Single Peptides , 1996, Science.

[106]  R. Liblau,et al.  Different patterns of TCR transgene expression in single-positive and double-negative T cells. Evidence for separate pathways of T cell maturation. , 1996, Journal of immunology.

[107]  P. Marrack,et al.  The Repertoire of T Cells Shaped by a Single MHC/Peptide Ligand , 1996, Cell.

[108]  P. Marrack,et al.  B cells are not essential for peripheral T-cell tolerance. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[109]  M. Foti,et al.  Ig-specific T cell receptor-transgenic T cells are not deleted in the thymus and are functional in vivo , 1996, The Journal of experimental medicine.

[110]  R. Flavell,et al.  An essential role for gp39, the ligand for CD40, in thymic selection , 1995, The Journal of experimental medicine.

[111]  F. Chan,et al.  A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. , 1995, Immunity.

[112]  G. Linette,et al.  Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77). , 1995, Science.

[113]  E. Krebs,et al.  Selective requirement for MAP kinase activation in thymocyte differentiation , 1995, Nature.

[114]  P. Allen,et al.  Modulation of T cell development by an endogenous altered peptide ligand , 1995, The Journal of experimental medicine.

[115]  D. Goeddel,et al.  Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice , 1994, Nature.

[116]  B. Stockinger,et al.  Mechanisms of tolerance induction in major histocompatibility complex class II-restricted T cells specific for a blood-borne self-antigen , 1994, The Journal of experimental medicine.

[117]  M. Katsuki,et al.  Origin of a T cell clone with a mismatched combination of MHC restriction and coreceptor expression. , 1994, Journal of immunology.

[118]  J. Sprent,et al.  T-cell apoptosis detected in situ during positive and negative selection in the thymus , 1994, Nature.

[119]  Susumu Tonegawa,et al.  High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice , 1994, Cell.

[120]  J. Curnow,et al.  The degree of CD8 dependence of cytolytic T cell precursors is determined by the nature of the T cell receptor (TCR) and influences negative selection in TCR‐transgenic mice , 1994, European journal of immunology.

[121]  H. Mcdevitt,et al.  A role for non-MHC genetic polymorphism in susceptibility to spontaneous autoimmunity. , 1994, Immunity.

[122]  A. Strasser,et al.  Positive and negative selection of T cells in T-cell receptor transgenic mice expressing a bcl-2 transgene. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[123]  L. Schwartz,et al.  Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate–early gene nur77 , 1994, Nature.

[124]  S. Korsmeyer,et al.  The T cell receptor repertoire of CD4-8+ thymocytes is altered by overexpression of the BCL-2 protooncogene in the thymus , 1994, The Journal of experimental medicine.

[125]  C. Benoist,et al.  Following a diabetogenic T cell from genesis through pathogenesis , 1993, Cell.

[126]  T. Mak,et al.  Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection , 1993, Cell.

[127]  L. Hood,et al.  Transgenic mice that express a myelin basic protein-specific T cell receptor develop spontaneous autoimmunity , 1993, Cell.

[128]  S. Weiss,et al.  Clonal deletion of specific thymocytes by an immunoglobulin idiotype. , 1993, The EMBO journal.

[129]  S. Hedrick,et al.  In vivo and in vitro clonal deletion of double-positive thymocytes , 1992, The Journal of experimental medicine.

[130]  R. Flavell,et al.  T-cell responsiveness to an oncogenic peripheral protein and spontaneous autoimmunity in transgenic mice. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[131]  G. Morahan,et al.  A nondeletional mechanism of peripheral tolerance in T-cell receptor transgenic mice. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[132]  S. Korsmeyer,et al.  bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes , 1991, Cell.

[133]  Suzanne Cory,et al.  bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship , 1991, Cell.

[134]  G. Schönrich,et al.  Down-regulation of T cell receptors on self-reactive T cells as a novel mechanism for extrathymic tolerance induction , 1991, Cell.

[135]  H. Pircher,et al.  Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen , 1989, Nature.

[136]  Mark M. Davis,et al.  Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand , 1989, Cell.

[137]  B. Kotzin,et al.  Deletion of potentially self-reactive T cell receptor specificities in L3T4-, Lyt-2- T cells of lpr mice [published erratum appears in J Exp Med 1989 Apr 1;169(4):1515-6] , 1988, The Journal of experimental medicine.

[138]  David M. Kranz,et al.  Positive and negative selection of an antigen receptor on T cells in transgenic mice , 1988, Nature.

[139]  H. Boehmer,et al.  Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes , 1988, Nature.

[140]  P. Marrack,et al.  T cell tolerance by clonal elimination in the thymus , 1987, Cell.

[141]  L. Peltonen,et al.  Aire regulates negative selection of organ-specific T cells , 2003, Nature Immunology.

[142]  T. Pawson,et al.  Disruption of T cell signaling networks and development by Grb2 haploid insufficiency , 2001, Nature Immunology.

[143]  D. Kioussis,et al.  Positive and Negative Selection in Transgenic Mice Expressing a T-Cell Receptor Specific for Influenza Nucleoprotein and Endogenous Superantigen , 1993, Developmental immunology.