TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial.
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N. Sugimoto | K. Muro | A. Ohtsu | H. Baba | T. Yoshino | C. Hamada | T. Nishina | T. Moriwaki | K. Yamaguchi | Y. Komatsu | A. Tsuji | Y. Tsuji | K. Yamazaki | T. Esaki | N. Mizunuma | T. Tanase
[1] A. Lièvre,et al. KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. , 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[2] A. Ohtsu,et al. Phase I study of TAS-102 treatment in Japanese patients with advanced solid tumours , 2012, British Journal of Cancer.
[3] F. Nakagawa,et al. A novel antimetabolite, TAS-102 retains its effect on FU-related resistant cancer cells. , 2004, International journal of molecular medicine.
[4] E. Van Cutsem,et al. Advanced colorectal cancer: ESMO Clinical Practice Guidelines for treatment. , 2010, Annals of oncology : official journal of the European Society for Medical Oncology.
[5] M. Fukushima,et al. Phase I study to determine the safety and pharmacokinetics of oral administration of TAS‐102 in patients with solid tumors , 2006, Cancer.
[6] W. Scheithauer,et al. XELOX vs FOLFOX-4 as first-line therapy for metastatic colorectal cancer: NO16966 updated results , 2011, British Journal of Cancer.
[7] A. Fujioka,et al. Abstract 1783: Trifluorothymidine incorporation into DNA strongly enforces the potential of TAS-102 and leads to remarkably prolonged survival of cancer patients , 2012 .
[8] M. Fukushima,et al. Phase 1 study of TAS-102 administered once daily on a 5-day-per-week schedule in patients with solid tumors , 2008, Investigational New Drugs.
[9] N. Suzuki,et al. Different mechanisms of acquired resistance to fluorinated pyrimidines in human colorectal cancer cells. , 2000, International journal of oncology.
[10] A. Jemal,et al. Global Cancer Statistics , 2011 .
[11] Y. Hirai. Structure and activity of IL-1. , 1990 .
[12] C. Tournigand,et al. FOLFIRI Followed by FOLFOX6 or the Reverse Sequence in Advanced Colorectal Cancer: A Randomized GERCOR Study , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[13] C. Sheridan. EGFR inhibitors embrace KRAS , 2008, Nature Biotechnology.
[14] Manish R. Patel,et al. A phase I dose-escalation study of TAS-102 in patients (pts) with refractory metastatic colorectal cancer (mCRC). , 2012 .
[15] W. Wolberg,et al. The clinical pharmacology of 5-trifluoromethyl-2'-deoxyuridine. , 1972, Cancer research.
[16] Marc Peeters,et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[17] Dongsheng Tu,et al. Cetuximab for the treatment of colorectal cancer. , 2007, The New England journal of medicine.
[18] M. Christian,et al. [New guidelines to evaluate the response to treatment in solid tumors]. , 2000, Bulletin du cancer.
[19] M. Fukushima,et al. Phase I Clinical Study of Three Times a Day Oral Administration of TAS-102 in Patients with Solid Tumors , 2008, Cancer investigation.
[20] N. Suzuki,et al. Structure and activity of specific inhibitors of thymidine phosphorylase to potentiate the function of antitumor 2'-deoxyribonucleosides. , 2000, Biochemical pharmacology.
[21] Giampietro Gasparini,et al. K-ras mutations and cetuximab in colorectal cancer. , 2009, The New England journal of medicine.