Predicting Mild Traumatic Brain Injury with Injury Risk Functions

To assess the safety of various products, equipment, and vehicles during traumatic events injury risk curves have been developed correlate measurable parameters with risk of injury. The first risk curves to predict head injuries focused on severe head injuries such as skull fractures. These curves were generated by impacting cadaver heads. To understand the biomechanics of mild traumatic brain injuries, cadaver heads have also been used to monitor pressure and strain in the brain during impacts. Live animal models have been used to understand the physiological response of the brain to impact to create thresholds for mild traumatic brain injuries such as concussions. These results have been scaled to humans. To generate injury risk curves from live human models, impacts from games in the NFL have been reconstructed in the laboratory. Helmets of NCAA football players have also be instrumented with accelerometers to collect all impacts during a season resulting in the development of injury risk curves that predict concussion as a function of both linear and rotational acceleration. These risk curves provide researchers with a better understanding of the efficacy of various safety systems and give insight as to how safety systems can be improved.

[1]  Yuko Nakahira,et al.  Head Injury Prediction Methods Based on 6 Degree of Freedom Head Acceleration Measurements during Impact , 2011 .

[2]  Bethany J. Wilcox,et al.  Head impact exposure in collegiate football players. , 2011, Journal of biomechanics.

[3]  Joel D Stitzel,et al.  Determination of significant parameters for eye injury risk from projectiles. , 2005, The Journal of trauma.

[4]  S. Duma,et al.  Validation of Concussion Risk Curves for Collegiate Football Players Derived from HITS Data , 2011, Annals of Biomedical Engineering.

[5]  R. Cantu,et al.  Measurement of Head Impacts in Collegiate Football Players: An Investigation of Positional and Event-type Differences , 2009 .

[6]  A. Kemper,et al.  Dynamic material properties of the pregnant human uterus. , 2012, Journal of biomechanics.

[7]  A E Hirsch,et al.  Tolerances for cerebral concussion from head impact and whiplash in primates. , 1971, Journal of biomechanics.

[8]  Stefan M. Duma,et al.  The Virginia Tech Response , 2012, Annals of Biomedical Engineering.

[9]  Joseph J Crisco,et al.  An algorithm for estimating acceleration magnitude and impact location using multiple nonorthogonal single-axis accelerometers. , 2004, Journal of biomechanical engineering.

[10]  Steven P. Broglio,et al.  High School and Collegiate Football Athlete Concussions: A Biomechanical Review , 2011, Annals of Biomedical Engineering.

[11]  K Sellier [Biomechanics of trauma]. , 1972, Beitrage zur gerichtlichen Medizin.

[12]  Stefan M. Duma,et al.  Brain Injury Prediction: Assessing the Combined Probability of Concussion Using Linear and Rotational Head Acceleration , 2013, Annals of Biomedical Engineering.

[13]  Stephen W. Marshall,et al.  Head Impact Biomechanics in Youth Hockey: Comparisons Across Playing Position, Event Types, and Impact Locations , 2011, Annals of Biomedical Engineering.

[14]  Stefan M Duma,et al.  Can Footwear Affect Achilles Tendon Loading? , 2010, Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine.

[15]  Joseph J Crisco,et al.  Spectrum of acute clinical characteristics of diagnosed concussions in college athletes wearing instrumented helmets: clinical article. , 2012, Journal of neurosurgery.

[16]  J. Crisco,et al.  Frequency and location of head impact exposures in individual collegiate football players. , 2010, Journal of athletic training.

[17]  J. Crandall,et al.  Dynamic injury tolerances for long bones of the female upper extremity , 1999, Journal of anatomy.

[18]  T. Rowland,et al.  Head Impacts During High School Football: A Biomechanical Assessment , 2010 .

[19]  Scott Tashman,et al.  A study of the response of the human cadaver head to impact. , 2007, Stapp car crash journal.

[20]  Joseph J Crisco,et al.  Head impact exposure sustained by football players on days of diagnosed concussion. , 2013, Medicine and science in sports and exercise.

[21]  Stephen W Marshall,et al.  Descriptive epidemiology of collegiate women's field hockey injuries: National Collegiate Athletic Association Injury Surveillance System, 1988-1989 through 2002-2003. , 2007, Journal of athletic training.

[22]  Harold J. Mertz,et al.  INJURY RISK CURVES FOR CHILDREN AND ADULTS IN FRONTAL AND REAR COLLISIONS , 1997 .

[23]  Jason P Mihalik,et al.  MEASUREMENT OF HEAD IMPACTS IN COLLEGIATE FOOTBALL PLAYERS: AN INVESTIGATION OF POSITIONAL AND EVENT‐TYPE DIFFERENCES , 2007, Neurosurgery.

[24]  J. Crisco,et al.  Rotational Head Kinematics in Football Impacts: An Injury Risk Function for Concussion , 2011, Annals of Biomedical Engineering.

[25]  Stefan M. Duma,et al.  Head Impact Exposure in Youth Football , 2012, Annals of Biomedical Engineering.

[26]  E. H. Harris,et al.  Scaling of Experimental Data on Cerebral Concussion in Sub-Human Primates to Concussion Threshold for Man , 1967 .

[27]  Joseph J Crisco,et al.  Timing of concussion diagnosis is related to head impact exposure prior to injury. , 2013, Medicine and science in sports and exercise.

[28]  Stefan M. Duma,et al.  Development of the STAR Evaluation System for Football Helmets: Integrating Player Head Impact Exposure and Risk of Concussion , 2011, Annals of Biomedical Engineering.

[29]  Steven Rowson,et al.  Linear and angular head acceleration measurements in collegiate football. , 2009, Journal of biomechanical engineering.

[30]  A E Hirsch,et al.  Cerebral Concussion in the Monkey: An Experimental Model , 1966, Science.

[31]  Bethany J. Wilcox,et al.  Magnitude of head impact exposures in individual collegiate football players. , 2012, Journal of applied biomechanics.

[32]  Joseph J Crisco,et al.  Analysis of Real-time Head Accelerations in Collegiate Football Players , 2005, Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine.

[33]  Joel D. Stitzel,et al.  Predicting fractures due to blunt impact: a sensitivity analysis of the effects of altering failure strain of human rib cortical bone , 2004 .

[34]  J J Crisco,et al.  Solitary sclerosis: Progressive myelopathy from solitary demyelinating lesion , 2012, Neurology.

[35]  Stephen W Marshall,et al.  Descriptive epidemiology of collegiate men's football injuries: National Collegiate Athletic Association Injury Surveillance System, 1988-1989 through 2003-2004. , 2007, Journal of athletic training.

[36]  S. Marshall,et al.  MEASUREMENT OF HEAD IMPACTS IN COLLEGIATE FOOTBALL PLAYERS: RELATIONSHIP BETWEEN HEAD IMPACT BIOMECHANICS AND ACUTE CLINICAL OUTCOME AFTER CONCUSSION , 2007, Neurosurgery.

[37]  Sarah J Manoogian,et al.  Effect of strain rate on the tensile material properties of human placenta. , 2009, Journal of biomechanical engineering.

[38]  A. Kemper,et al.  Reducing Chest Injuries in Automobile Collisions: Rib Fracture Timing and Implications for Thoracic Injury Criteria , 2011, Annals of Biomedical Engineering.

[39]  A. Gordon Concussion in professional football: reconstruction of game impacts and injuries. , 2004, Neurosurgery.

[40]  S. M. Beeman,et al.  Mechanisms of eye injuries from fireworks. , 2012, JAMA.

[41]  J. Beckwith,et al.  Measuring Head Kinematics in Football: Correlation Between the Head Impact Telemetry System and Hybrid III Headform , 2011, Annals of Biomedical Engineering.

[42]  Stefan M. Duma,et al.  The temperature inside football helmets during head impact: a five-year study of collegiate football games , 2013 .

[43]  S. Duma,et al.  Past, present, and future of head injury research. , 2011, Exercise and sport sciences reviews.