NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathies.
暂无分享,去创建一个
Danielle K. Manning | Jia-Ren Lin | D. Beier | S. Boulton | R. Giles | G. Slaats | Andrew C. Kile | Jean-Baptiste Vannier | Karlene A. Cimprich | Hyo Jei Claudia Choi | R. Paulsen
[1] T. Helleday,et al. Increased replication initiation and conflicts with transcription underlie Cyclin E-induced replication stress , 2013, Oncogene.
[2] R. Bayliss,et al. Cell cycle regulation by the NEK family of protein kinases , 2012, Journal of Cell Science.
[3] S. Patzke,et al. Cyclin-Dependent Kinase Suppression by WEE1 Kinase Protects the Genome through Control of Replication Initiation and Nucleotide Consumption , 2012, Molecular and Cellular Biology.
[4] John K. McCooke,et al. A novel mutation causing nephronophthisis in the Lewis polycystic kidney rat localises to a conserved RCC1 domain in Nek8 , 2012, BMC Genomics.
[5] A. Nussenzweig,et al. Loss of ATM kinase activity leads to embryonic lethality in mice , 2012, The Journal of cell biology.
[6] S. Zha,et al. Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice , 2012, The Journal of cell biology.
[7] Colin A. Johnson,et al. Exome Capture Reveals ZNF423 and CEP164 Mutations, Linking Renal Ciliopathies to DNA Damage Response Signaling , 2012, Cell.
[8] H. Moch,et al. FAN1 mutations cause karyomegalic interstitial nephritis, linking chronic kidney failure to defective DNA damage repair , 2012, Nature Genetics.
[9] A. Lengronne,et al. Analysis of DNA replication profiles in budding yeast and mammalian cells using DNA combing. , 2012, Methods.
[10] Rebecca M. Jones,et al. Replication fork dynamics and the DNA damage response. , 2012, The Biochemical journal.
[11] R. Bayliss,et al. The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis , 2011, Human molecular genetics.
[12] V. Stambolic,et al. Nek family of kinases in cell cycle, checkpoint control and cancer , 2011, Cell Division.
[13] R. Syljuåsen,et al. Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication , 2011, Nucleic acids research.
[14] R. Medema,et al. Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease , 2011, The Journal of cell biology.
[15] D. Cortez,et al. Analysis of protein dynamics at active, stalled, and collapsed replication forks. , 2011, Genes & development.
[16] Matthew J. Brauer,et al. Mapping the NPHP-JBTS-MKS Protein Network Reveals Ciliopathy Disease Genes and Pathways , 2011, Cell.
[17] S. Elledge,et al. The DNA damage response: making it safe to play with knives. , 2010, Molecular cell.
[18] T. Helleday,et al. Chk1 promotes replication fork progression by controlling replication initiation , 2010, Proceedings of the National Academy of Sciences.
[19] T. Helleday,et al. Regulators of cyclin-dependent kinases are crucial for maintaining genome integrity in S phase , 2010, The Journal of cell biology.
[20] Marco Foiani,et al. Maintaining genome stability at the replication fork , 2010, Nature Reviews Molecular Cell Biology.
[21] T. Chibazakura,et al. Cyclin A overexpression induces chromosomal double-strand breaks in mammalian cells , 2009, Cell cycle.
[22] R. Wollman,et al. A genome-wide siRNA screen reveals diverse cellular processes and pathways that mediate genome stability. , 2009, Molecular cell.
[23] H. Niida,et al. Cyclin A–Cdk1 regulates the origin firing program in mammalian cells , 2009, Proceedings of the National Academy of Sciences.
[24] Anastasia Khvorova,et al. Identification of genes that regulate epithelial cell migration using an siRNA screening approach , 2008, Nature Cell Biology.
[25] J. L. Rosa,et al. The RCC1 superfamily: from genes, to function, to disease. , 2008, Biochimica et biophysica acta.
[26] D. Cortez,et al. ATR: an essential regulator of genome integrity , 2008, Nature Reviews Molecular Cell Biology.
[27] Shaohui Wang,et al. Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1. , 2008, Genes & development.
[28] F. Hildebrandt,et al. NEK8 mutations affect ciliary and centrosomal localization and may cause nephronophthisis. , 2008, Journal of the American Society of Nephrology : JASN.
[29] R. Kanaar,et al. The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks , 2007, Nature Structural &Molecular Biology.
[30] K. Cimprich,et al. The ATR pathway: fine-tuning the fork. , 2007, DNA repair.
[31] D. Gillespie,et al. Chk1 regulates the density of active replication origins during the vertebrate S phase , 2007, The EMBO journal.
[32] J Audouin,et al. TRAF4 overexpression is a common characteristic of human carcinomas , 2007, Oncogene.
[33] Laurie A. Smith,et al. Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine , 2006, Nature.
[34] Marcus B. Smolka,et al. Checkpoint proteins control morphogenetic events during DNA replication stress in Saccharomyces cerevisiae , 2006, The Journal of cell biology.
[35] Laurie A. Smith,et al. Development of polycystic kidney disease in juvenile cystic kidney mice: insights into pathogenesis, ciliary abnormalities, and common features with human disease. , 2006, Journal of the American Society of Nephrology : JASN.
[36] Y. Shiloh,et al. Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway , 2006, Nature Cell Biology.
[37] S. Jackson,et al. Rapid PIKK-Dependent Release of Chk1 from Chromatin Promotes the DNA-Damage Checkpoint Response , 2006, Current Biology.
[38] M. Mahjoub,et al. NIMA-related kinases defective in murine models of polycystic kidney diseases localize to primary cilia and centrosomes. , 2005, Journal of the American Society of Nephrology : JASN.
[39] T. Ørntoft,et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis , 2005, Nature.
[40] J. Gautier,et al. ATR and ATM regulate the timing of DNA replication origin firing , 2004, Nature Cell Biology.
[41] J. Boylan,et al. Nek8, a NIMA family kinase member, is overexpressed in primary human breast tumors. , 2004, Gene.
[42] K. Dewar,et al. A defect in a novel Nek-family kinase causes cystic kidney disease in the mouse and in zebrafish , 2002, Development.
[43] S. Elledge,et al. Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. , 1997, Science.
[44] S Povey,et al. Dynamic molecular combing: stretching the whole human genome for high-resolution studies. , 1997, Science.
[45] Roy G van Heesbeen,et al. Loss of the ciliary kinase Nek8 causes left-right asymmetry defects. , 2013, Journal of the American Society of Nephrology : JASN.
[46] H. Niida,et al. Chk1–cyclin A/Cdk1 axis regulates origin firing programs in mammals , 2009, Chromosome Research.