Surgical resection for metastatic melanoma to the lung.

From 1971 through December 1986, the courses of 47 patients who underwent thoracotomy for pulmonary metastases from melanoma were retrospectively reviewed to determine the efficacy of this approach in the management of selected patients with melanoma. The overall five-year survival rate was 25% (median survival, 19 months). Thirty-eight patients were free of disease following thoracotomy. These patients fared significantly better than those who had residual disease following thoracotomy, with a five-year survival rate of 31% (median survival, 24 months) compared with 0% (median survival, six months). Survival was not influenced by the addition of adjuvant therapy or duration of time before the development of metastases (less than 12 months vs greater than or equal to 12 months). In selected patients with melanoma metastatic to the lung, thoracotomy with complete excision of the metastatic deposits results in improved survival and should be considered the treatment of choice.

[1]  C. McGaff,et al.  Treatment of Cancer of the Liver: Twenty Years' Experience with Infusion and Resection in 414 Patients , 1988, Annals of surgery.

[2]  J. Olak,et al.  Hepatic resection for metastatic disease. , 1986, Canadian journal of surgery. Journal canadien de chirurgie.

[3]  C. Balch,et al.  Surgery as Palliative Treatment for Distant Metastases of Melanoma , 1986, Annals of surgery.

[4]  R. Andersson,et al.  Major liver resection: perioperative course and management. , 1986, Surgery.

[5]  M. Shiu,et al.  Surgical treatment of distant metastatic melanoma indications and results , 1985, Cancer.

[6]  F. Meyskens,et al.  Clinical-biologic patterns of metastatic melanoma and their effect on treatment. , 1985, Cancer treatment reports.

[7]  C. Mountain,et al.  Surgery for pulmonary metastasis: a 20-year experience. , 1984, The Annals of thoracic surgery.

[8]  D. Morton.  Surgical treatment for malignant melanoma , 1984 .

[9]  C. Karakousis,et al.  Surgery in recurrent malignant melanoma , 1983, Cancer.

[10]  D. Papachristou,et al.  Surgical treatment of metastatic melanoma confined to the liver. , 1983, International surgery.

[11]  T. Starzl,et al.  Experience with 150 Liver Resections , 1983, Annals of surgery.

[12]  C. Fontolliet,et al.  Resection of metastases to the alimentary tract from malignant melanoma. , 1982, International surgery.

[13]  D. Tarin,et al.  Influence of microenvironment and vascular anatomy on "metastatic" colonization potential of mammary tumors. , 1981, Cancer research.

[14]  C. Stackpole.  Distinct lung-colonizing and lung-metastasizing cell populations in B16 mouse melanoma , 1981, Nature.

[15]  J. Talmadge,et al.  In vitro characteristics of metastatic variant subclones of restricted genetic origin. , 1981, Journal of supramolecular structure and cellular biochemistry.

[16]  D. Fell,et al.  Surgical versus nonsurgical management of metastatic melanoma of the brain. , 1980, Neurosurgery.

[17]  P. Vassilopoulos,et al.  Surgical resection for metastatic neoplasms of the lung: Experience at the university of minnesota hospitals , 1980, Cancer.

[18]  B. Brandt,et al.  Surgical management of pulmonary metastasis. , 1980, Current problems in cancer.

[19]  S. Passe,et al.  Surgical treatment of single brain metastasis: Factors associated with survival , 1980, Cancer.

[20]  V. Vaitkevicius,et al.  Clinical presentation, natural history and prognostic factors in advanced malignant melanoma. , 1979, Surgery, gynecology & obstetrics.

[21]  M. S. Blois,et al.  The thorax as the initial site for systemic relapse in malignant melanoma. A prospective survey of 324 patients , 1979, Cancer.

[22]  D. Mathisen,et al.  The role of thoracotomy in the management of pulmonary metastases from malignant melanoma. , 1979, The Annals of thoracic surgery.

[23]  J. Foster.  Survival after liver resection for secondary tumors. , 1978, American journal of surgery.

[24]  Comis Rl.  DTIC (NSC-45388) in malignant melanoma: a perspective. , 1976 .

[25]  L. Einhorn,et al.  Prognostic correlations and response to treatment in advanced metastatic malignant melanoma. , 1974, Cancer research.

[26]  W. Cahan.  Excision of Melanoma Metastases to Lung: Problems in Diagnosis and Management , 1973, Annals of surgery.

[27]  D. Morton,et al.  Surgical Resection and Adjunctive lmmunotherapy for Selected Patients with Multiple Pulmonary Metastases , 1973, Annals of surgery.

[28]  D. Morton,et al.  Prognostic significance of tumor doubling time in evaluating operability in pulmonary metastatic disease. , 1971, The Journal of thoracic and cardiovascular surgery.

[29]  E. Kaplan,et al.  Nonparametric Estimation from Incomplete Observations , 1958 .