Activation of cardiac Cdk9 represses PGC‐1 and confers a predisposition to heart failure

[1]  E. Dufour,et al.  A switch in metabolism precedes increased mitochondrial biogenesis in respiratory chain-deficient mouse hearts. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[2]  R. Scarpulla,et al.  Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. , 2004, Genes & development.

[3]  S. Korsmeyer,et al.  Cell Death Critical Control Points , 2004, Cell.

[4]  S. Buratowski,et al.  Phosphorylation of serine 2 within the RNA polymerase II C-terminal domain couples transcription and 3' end processing. , 2004, Molecular cell.

[5]  B. Peterlin,et al.  Dynamics of Human Immunodeficiency Virus Transcription: P-TEFb Phosphorylates RD and Dissociates Negative Effectors from the Transactivation Response Element , 2004, Molecular and Cellular Biology.

[6]  John W. Adams,et al.  Akt-mediated Cardiomyocyte Survival Pathways Are Compromised by Gαq-induced Phosphoinositide 4,5-Bisphosphate Depletion* , 2003, Journal of Biological Chemistry.

[7]  A. Link,et al.  Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA. , 2003, Molecular cell.

[8]  Michael D. Schneider,et al.  Sizing up the heart: development redux in disease. , 2003, Genes & development.

[9]  H. Izumi,et al.  p300/CBP-associated factor (P/CAF) interacts with nuclear respiratory factor-1 to regulate the UDP-N-acetyl-alpha-d-galactosamine: polypeptide N-acetylgalactosaminyltransferase-3 gene. , 2003, The Biochemical journal.

[10]  O. Bensaude,et al.  MAQ1 and 7SK RNA Interact with CDK9/Cyclin T Complexes in a Transcription-Dependent Manner , 2003, Molecular and Cellular Biology.

[11]  Jiandie D. Lin,et al.  An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[12]  Michael D. Schneider,et al.  Telomere attrition and Chk2 activation in human heart failure , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[13]  B. Peterlin,et al.  A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb. , 2003, Genes & development.

[14]  G. Fishman,et al.  Regulation of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) and mitochondrial function by MEF2 and HDAC5 , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[15]  A. Giordano,et al.  Activation and function of cyclin T–Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy , 2002, Nature Medicine.

[16]  P. Farnham,et al.  Myc Recruits P-TEFb to Mediate the Final Step in the Transcriptional Activation of the cad Promoter* , 2002, The Journal of Biological Chemistry.

[17]  Yang Shi,et al.  CDK-9/cyclin T (P-TEFb) is required in two postinitiation pathways for transcription in the C. elegans embryo. , 2002, Genes & development.

[18]  C. Gustafsson,et al.  Mitochondrial transcription factors B1 and B2 activate transcription of human mtDNA , 2002, Nature Genetics.

[19]  Richard A Young,et al.  Exchange of RNA polymerase II initiation and elongation factors during gene expression in vivo. , 2002, Molecular cell.

[20]  D. Kelly,et al.  Transcriptional Activation Of Energy Metabolic Switches In The Developing And Hypertrophied Heart , 2002, Clinical and experimental pharmacology & physiology.

[21]  G. Orphanides,et al.  A Unified Theory of Gene Expression , 2002, Cell.

[22]  B. Peterlin,et al.  NF-κB Binds P-TEFb to Stimulate Transcriptional Elongation by RNA Polymerase II , 2001 .

[23]  Derrick J. Rossi,et al.  Inability to enter S phase and defective RNA polymerase II CTD phosphorylation in mice lacking Mat1 , 2001, The EMBO journal.

[24]  B. Foster,et al.  Adenovirus-mediated transfer of inducible caspases: a novel "death switch" gene therapeutic approach to prostate cancer. , 2001, Cancer research.

[25]  John W. Adams,et al.  Cardiomyocyte Apoptosis Induced by G&agr;q Signaling Is Mediated by Permeability Transition Pore Formation and Activation of the Mitochondrial Death Pathway , 2000, Circulation research.

[26]  J. Saffitz,et al.  Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. , 2000, The Journal of clinical investigation.

[27]  E. Cho,et al.  Different phosphorylated forms of RNA polymerase II and associated mRNA processing factors during transcription. , 2000, Genes & development.

[28]  J. Lis,et al.  P-TEFb kinase recruitment and function at heat shock loci. , 2000, Genes & development.

[29]  D. Price.  P-TEFb, a Cyclin-Dependent Kinase Controlling Elongation by RNA Polymerase II , 2000, Molecular and Cellular Biology.

[30]  A. Giordano,et al.  Physical interaction between CDK9 and B-Myb results in suppression of B-Myb gene autoregulation , 2000, Oncogene.

[31]  V. Mootha,et al.  Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1 , 1999, Cell.

[32]  R. Gaynor,et al.  Role of the human and murine cyclin T proteins in regulating HIV-1 tat-activation. , 1999, Journal of molecular biology.

[33]  J. Ross,et al.  Loss of a gp130 Cardiac Muscle Cell Survival Pathway Is a Critical Event in the Onset of Heart Failure during Biomechanical Stress , 1999, Cell.

[34]  J. Gearhart,et al.  Growth retardation and neonatal lethality in mice with a homozygous deletion in the C-terminal domain of RNA polymerase II , 1999, Molecular and General Genetics MGG.

[35]  John W. Adams,et al.  Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[36]  G. Dorn,et al.  Decompensation of Pressure-Overload Hypertrophy in Gαq-Overexpressing Mice , 1998 .

[37]  L. Kirshenbaum,et al.  The bcl-2 gene product prevents programmed cell death of ventricular myocytes. , 1997, Circulation.

[38]  D. Wallace,et al.  A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator , 1997, Nature Genetics.

[39]  C. Epstein,et al.  Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase , 1995, Nature Genetics.

[40]  R. Conaway,et al.  The RNA polymerase II elongation complex , 1995, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[41]  G. Fishman,et al.  Regulation of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha ) and mitochondrial function by MEF2 and HDAC5. , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[42]  Jiandie D. Lin,et al.  An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle. , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[43]  B. Peterlin,et al.  NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II. , 2001, Molecular cell.

[44]  K. Kinzler,et al.  A simplified system for generating recombinant adenoviruses. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[45]  G. Dorn,et al.  Decompensation of pressure-overload hypertrophy in G alpha q-overexpressing mice. , 1998, Circulation.