Proof‐of‐concept prototype time‐of‐flight PET system based on high‐quantum‐efficiency multianode PMTs

Purpose: Time‐of‐flight (TOF) information in positron emission tomography (PET) scanners enhances the diagnostic power of PET scans owing to the increased signal‐to‐noise ratio of reconstructed images. There are numerous additional benefits of TOF reconstruction, including the simultaneous estimation of activity and attenuation distributions from emission data only. Exploring further TOF gains by using TOF PET scanners is important because it can broaden the applications of PET scans and expand our understanding of TOF techniques. Herein, we present a prototype TOF PET scanner with fine‐time performance that can experimentally demonstrate the benefits of TOF information. Methods: A single‐ring PET system with a coincidence resolving time of 360 ps and a spatial resolution of 3.1/2.2 mm (filtered backprojection/ordered‐subset expectation maximization) was developed. The scanner was based on advanced high‐quantum‐efficiency (high‐QE) multianode photomultiplier tubes (PMTs). The impact of its fine‐time performance was demonstrated by evaluating body phantom images reconstructed with and without TOF information. Moreover, the feasibility of the scanner as an experimental validator of TOF gains was verified by investigating the improvement of images under various conditions, such as the use of joint estimation algorithms of activity and attenuation, erroneous data correction factors (e.g., without normalization correction), and incompletely sampled data. Results: The prototype scanner showed excellent performance, producing improved phantom images, when TOF information was employed in the reconstruction process. In addition, investigation of the TOF benefits using the phantom data in different conditions verified the usefulness of the developed system for demonstrating the practical effects of TOF reconstruction. Conclusions: We developed a prototype TOF PET scanner with good performance and a fine‐timing resolution based on advanced high‐QE multianode PMTs and demonstrated its feasibility as an experimental validator of TOF gains, suggesting its usefulness for investigating new applications of PET scans and clarifying TOF techniques in detail.

[1]  H. Du,et al.  A new modular and scalable detector for a Time-of-Flight PET scanner , 2012, 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC).

[2]  In Chan Song,et al.  Simultaneous Multiparametric PET/MRI with Silicon Photomultiplier PET and Ultra-High-Field MRI for Small-Animal Imaging , 2016, The Journal of Nuclear Medicine.

[3]  Jae Sung Lee,et al.  Initial Results of Simultaneous PET/MRI Experiments with an MRI-Compatible Silicon Photomultiplier PET Scanner , 2012, The Journal of Nuclear Medicine.

[4]  Jian Zhou,et al.  Performance of the Tachyon Time-of-Flight PET Camera , 2015, IEEE Transactions on Nuclear Science.

[5]  J. Karp,et al.  Design considerations for a limited angle, dedicated breast, TOF PET scanner , 2007, 2007 IEEE Nuclear Science Symposium Conference Record.

[6]  W. Enghardt,et al.  Direct time-of-flight for quantitative, real-time in-beam PET: a concept and feasibility study , 2007, Physics in medicine and biology.

[7]  Jun Yeon Won,et al.  Development and Performance Evaluation of a Time-of-Flight Positron Emission Tomography Detector Based on a High-Quantum-Efficiency Multi-Anode Photomultiplier Tube , 2016, IEEE Transactions on Nuclear Science.

[8]  W. Moses Time of flight in PET revisited , 2003 .

[9]  J. Mrázek,et al.  Timing performance of ZnO:Ga nanopowder composite scintillators , 2016 .

[10]  Jae Sung Lee,et al.  Bipolar analog signal multiplexing for position-sensitive PET block detectors , 2014, Physics in medicine and biology.

[11]  R. Lecomte,et al.  Scintillation characteristics of 90%Lu LGSO with different decay times , 2014, 2014 IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC).

[12]  Maurizio Conti,et al.  Simultaneous Reconstruction of Activity and Attenuation in Time-of-Flight PET , 2012, IEEE Transactions on Medical Imaging.

[13]  Suleman Surti,et al.  Benefit of Time-of-Flight in PET: Experimental and Clinical Results , 2008, Journal of Nuclear Medicine.

[14]  Sun Il Kwon,et al.  Development of Position Encoding Circuit for a Multi-Anode Position Sensitive Photomultiplier Tube. , 2008 .

[15]  Jeffrey A. Fessler,et al.  Joint estimation of activity distribution and attenuation map for TOF-PET using alternating direction method of multiplier , 2016, 2016 IEEE 13th International Symposium on Biomedical Imaging (ISBI).

[16]  S. Lapi,et al.  Designing the Magic Bullet? The Advancement of Immuno-PET into Clinical Use , 2013, The Journal of Nuclear Medicine.

[17]  윤현석,et al.  Network based High Performance Data Acquisition System for PET Scanner , 2015 .

[18]  D. Townsend,et al.  Impact of Time-of-Flight on PET Tumor Detection , 2009, Journal of Nuclear Medicine.

[19]  Y. Ikoma,et al.  Development of a simultaneous optical/PET imaging system for awake mice , 2016, Physics in medicine and biology.

[20]  M. V. Nemallapudi,et al.  Sub-100 ps coincidence time resolution for positron emission tomography with LSO:Ce codoped with Ca , 2015, Physics in medicine and biology.

[21]  H. Watabe,et al.  Performance comparison of high quantum efficiency and normal quantum efficiency photomultiplier tubes and position sensitive photomultiplier tubes for high resolution PET and SPECT detectors. , 2012, Medical physics.

[22]  Tetsuya Shinaji,et al.  Development of a small single-ring OpenPET prototype with a novel transformable architecture , 2016, Physics in medicine and biology.

[23]  Christopher Kurz,et al.  Investigating the limits of PET/CT imaging at very low true count rates and high random fractions in ion-beam therapy monitoring. , 2015, Medical physics.

[24]  D. Townsend,et al.  Physical and clinical performance of the mCT time-of-flight PET/CT scanner , 2011, Physics in medicine and biology.

[25]  Paul Lecoq,et al.  Ultrafast emission from colloidal nanocrystals under pulsed X-ray excitation , 2016 .

[26]  J. S. Karp,et al.  Design Optimization of a Time-Of-Flight, Breast PET Scanner , 2013, IEEE Transactions on Nuclear Science.

[27]  Renaud Lhommel,et al.  Yttrium-90 TOF PET scan demonstrates high-resolution biodistribution after liver SIRT , 2009, European Journal of Nuclear Medicine and Molecular Imaging.

[28]  V. Bettinardi,et al.  Physical performance of the new hybrid PET∕CT Discovery-690. , 2011, Medical physics.

[29]  Jungah Son,et al.  Gap compensation during PET image reconstruction by constrained, total variation minimization. , 2012, Medical physics.

[30]  Jae Sung Lee,et al.  A depth-of-interaction PET detector using a stair-shaped reflector arrangement and a single-ended scintillation light readout , 2017, Physics in medicine and biology.

[31]  E. Auffray,et al.  How photonic crystals can improve the timing resolution of scintillators , 2012, 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC).

[32]  K. Becker,et al.  Single photon test bench for series tests of HAMAMATSU H12700 MAPMTs , 2017 .

[33]  Yun Dong,et al.  A High-Resolution Time-of-Flight Clinical PET Detection System Using a Gapless PMT-Quadrant-Sharing Method , 2015, IEEE Transactions on Nuclear Science.

[34]  M. Daube-Witherspoon,et al.  The imaging performance of a LaBr3-based PET scanner , 2010, Physics in medicine and biology.

[35]  Johan Nuyts,et al.  ML-reconstruction for TOF-PET with simultaneous estimation of the attenuation factors , 2014, 2012 IEEE Nuclear Science Symposium and Medical Imaging Conference Record (NSS/MIC).

[36]  Jae Sung Lee,et al.  Dual-Phase Tapped-Delay-Line Time-to-Digital Converter With On-the-Fly Calibration Implemented in 40 nm FPGA , 2016, IEEE Transactions on Biomedical Circuits and Systems.

[37]  Joshua W Cates,et al.  Advances in coincidence time resolution for PET , 2016, Physics in medicine and biology.

[38]  Mikiko Ito,et al.  A novel compensation method for the anode gain non-uniformity of multi-anode photomultiplier tubes. , 2012, Physics in medicine and biology.

[39]  M. Conti Why is TOF PET reconstruction a more robust method in the presence of inconsistent data? , 2011, Physics in medicine and biology.

[40]  Giorgio Fallica,et al.  Silicon Photomultipliers Signal-to-Noise Ratio in the Continuous Wave Regime , 2014, IEEE Journal of Selected Topics in Quantum Electronics.

[41]  Abdus Sattar,et al.  Image Quality and Diagnostic Performance of a Digital PET Prototype in Patients with Oncologic Diseases: Initial Experience and Comparison with Analog PET , 2015, The Journal of Nuclear Medicine.

[42]  Kan Yang,et al.  Effects of $\hbox {Ca}^{2+}$ Co-Doping on the Scintillation Properties of LSO:Ce , 2008, IEEE Transactions on Nuclear Science.

[43]  K. Langen,et al.  Organ motion and its management. , 2001, International journal of radiation oncology, biology, physics.

[44]  J S Karp,et al.  Design study of an in situ PET scanner for use in proton beam therapy , 2011, Physics in medicine and biology.

[45]  M. V. Nemallapudi,et al.  State of the art timing in TOF-PET detectors with LuAG, GAGG and L(Y)SO scintillators of various sizes coupled to FBK-SiPMs , 2016 .

[46]  D. Townsend,et al.  An Assessment of the Impact of Incorporating Time-of-Flight Information into Clinical PET/CT Imaging , 2010, Journal of Nuclear Medicine.

[47]  G. Ko,et al.  Performance characterization of high quantum efficiency metal package photomultiplier tubes for time-of-flight and high-resolution PET applications. , 2015, Medical physics.

[48]  Eiji Yoshida,et al.  Performance evaluation of a depth-of-interaction detector by use of position-sensitive PMT with a super-bialkali photocathode , 2013, Radiological Physics and Technology.