Centrosome amplification: a quantifiable cancer cell trait with prognostic value in solid malignancies

[1]  Mahasin A. Osman,et al.  IQGAP1 control of centrosome function defines distinct variants of triple negative breast cancer , 2020, Oncotarget.

[2]  M. Burkard,et al.  Centrosome amplification is a frequent event in circulating tumor cells from subjects with metastatic breast cancer , 2020, Molecular oncology.

[3]  P. Gao,et al.  Decreased Nek9 expression correlates with aggressive behaviour and predicts unfavourable prognosis in breast cancer. , 2020, Pathology.

[4]  K. Mittal,et al.  Spotlighting the hypoxia‐centrosome amplification axis , 2020, Medicinal research reviews.

[5]  Christopher C. Griffith,et al.  Hypoxia-Induced Centrosome Amplification Underlies Aggressive Disease Course in HPV-Negative Oropharyngeal Squamous Cell Carcinomas , 2020, Cancers.

[6]  A. Green,et al.  A Quantitative Centrosomal Amplification Score Predicts Local Recurrence of Ductal Carcinoma In Situ , 2020, Clinical Cancer Research.

[7]  G. C. Rogers,et al.  A method of quantifying centrosomes at the single-cell level in human normal and cancer tissue , 2019, Molecular biology of the cell.

[8]  C. Pearson,et al.  CEP135 isoform dysregulation promotes centrosome amplification in breast cancer cells , 2019, Molecular biology of the cell.

[9]  M. Burkard,et al.  Polo-like kinase 4 maintains centriolar satellite integrity by phosphorylation of centrosomal protein 131 (CEP131) , 2019, The Journal of Biological Chemistry.

[10]  R. Osan,et al.  Abstract P5-18-02: A quantitative centrosomal amplification score (CAS) predicts local recurrence in ductal carcinoma in situ , 2019, Poster Session Abstracts.

[11]  M. Shiota,et al.  KIFC1 Inhibitor CW069 Induces Apoptosis and Reverses Resistance to Docetaxel in Prostate Cancer , 2019, Journal of clinical medicine.

[12]  A. Yasui,et al.  RACK1 regulates centriole duplication by controlling localization of BRCA1 to the centrosome in mammary tissue-derived cells , 2019, Oncogene.

[13]  A. Hyman,et al.  Inhibition of CPAP–tubulin interaction prevents proliferation of centrosome‐amplified cancer cells , 2018, The EMBO journal.

[14]  C. Chelala,et al.  Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion , 2018, Developmental cell.

[15]  J. Pereira-Leal,et al.  Centrosome amplification arises before neoplasia and increases upon p53 loss in tumorigenesis , 2018, The Journal of cell biology.

[16]  Imran S. Vohra,et al.  In Vivo Multimodal Optical Imaging: Improved Detection of Oral Dysplasia in Low-Risk Oral Mucosal Lesions , 2018, Cancer Prevention Research.

[17]  C. Ishioka,et al.  BRCA1-Interacting Protein OLA1 Requires Interaction with BARD1 to Regulate Centrosome Number , 2018, Molecular Cancer Research.

[18]  André F. Vieira,et al.  Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation , 2018, Nature Communications.

[19]  M. Burkard,et al.  Centriole Overduplication is the Predominant Mechanism Leading to Centrosome Amplification in Melanoma , 2018, Molecular Cancer Research.

[20]  G. Charras,et al.  Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells , 2018, The Journal of cell biology.

[21]  Nicolai J. Birkbak,et al.  Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling , 2017, Nature Communications.

[22]  M. Dyer,et al.  Hsp72 and Nek6 Cooperate to Cluster Amplified Centrosomes in Cancer Cells. , 2017, Cancer research.

[23]  P. Rida,et al.  Centrosome amplification: a suspect in breast cancer and racial disparities. , 2017, Endocrine-related cancer.

[24]  H. Sugimura,et al.  WDR62 overexpression is associated with a poor prognosis in patients with lung adenocarcinoma , 2017, Molecular carcinogenesis.

[25]  R. Kiyama,et al.  Depletion of tumor suppressor Kank1 induces centrosomal amplification via hyperactivation of RhoA , 2017, Experimental cell research.

[26]  Y. Shang,et al.  USP9X regulates centrosome duplication and promotes breast carcinogenesis , 2017, Nature Communications.

[27]  S. Varambally,et al.  Amplified centrosomes and mitotic index display poor concordance between patient tumors and cultured cancer cells , 2017, Scientific Reports.

[28]  R. Reis,et al.  Centrosome amplification in chondrosarcomas: A primary cell culture and cryopreserved tumor sample study. , 2017, Oncology letters.

[29]  A. Jauch,et al.  Epstein–Barr virus particles induce centrosome amplification and chromosomal instability , 2017, Nature Communications.

[30]  D. Lambrechts,et al.  Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals. , 2017, Developmental cell.

[31]  P. Gönczy,et al.  KAT2A/KAT2B-targeted acetylome reveals a role for PLK4 acetylation in preventing centrosome amplification , 2016, Nature Communications.

[32]  Jesse C. Gatlin,et al.  Centrosomal clustering contributes to chromosomal instability and cancer. , 2016, Current opinion in biotechnology.

[33]  I. Shih,et al.  CCNE1 Amplification and Centrosome Number Abnormality in Serous Tubal Intraepithelial Carcinoma- Further Evidence Supporting its Role as a Precursor of Ovarian High-Grade Serous Carcinoma , 2016, Modern Pathology.

[34]  A. Hyman,et al.  Molecular basis for CPAP-tubulin interaction in controlling centriolar and ciliary length , 2016, Nature Communications.

[35]  T. Kundu,et al.  14-3-3γ Prevents Centrosome Amplification and Neoplastic Progression , 2016, Scientific Reports.

[36]  C. Woods,et al.  A CEP215–HSET complex links centrosomes with spindle poles and drives centrosome clustering in cancer , 2016, Nature Communications.

[37]  R. Kaur,et al.  A centrosome clustering protein, KIFC1, predicts aggressive disease course in serous ovarian adenocarcinomas , 2016, Journal of Ovarian Research.

[38]  M. Burkard,et al.  Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer , 2016, BMC Cancer.

[39]  S. Jang,et al.  A novel role for the deubiquitinase USP1 in the control of centrosome duplication , 2016, Cell cycle.

[40]  M. Zernicka-Goetz,et al.  Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse , 2015, Open Biology.

[41]  Jhih-Siang Syu,et al.  Chloroquine alleviates etoposide-induced centrosome amplification by inhibiting CDK2 in adrenocortical tumor cells , 2015, Oncogenesis.

[42]  Yongping Cui,et al.  Loss of KLF14 triggers centrosome amplification and tumorigenesis , 2015, Nature Communications.

[43]  S. Varambally,et al.  Amplified centrosomes may underlie aggressive disease course in pancreatic ductal adenocarcinoma , 2015, Cell cycle.

[44]  R. Osan,et al.  Rampant centrosome amplification underlies more aggressive disease course of triple negative breast cancers , 2015, Oncotarget.

[45]  F. Yamasaki,et al.  p16 Gene Transfer Induces Centrosome Amplification and Abnormal Nucleation Associated with Survivin Downregulation in Glioma Cells , 2015, Pathobiology.

[46]  P. Rida,et al.  HSET overexpression fuels tumor progression via centrosome clustering-independent mechanisms in breast cancer patients , 2015, Oncotarget.

[47]  M. Moussa,et al.  SKA1 over‐expression promotes centriole over‐duplication, centrosome amplification and prostate tumourigenesis , 2014, The Journal of pathology.

[48]  U. Scheer.  Historical roots of centrosome research: discovery of Boveri's microscope slides in Würzburg , 2014, Philosophical Transactions of the Royal Society B: Biological Sciences.

[49]  H. Sugimura,et al.  PLK4 overexpression and its effect on centrosome regulation and chromosome stability in human gastric cancer , 2014, Molecular Biology Reports.

[50]  R. Osan,et al.  KIFCI, a novel putative prognostic biomarker for ovarian adenocarcinomas: delineating protein interaction networks and signaling circuitries , 2014, Journal of Ovarian Research.

[51]  C. Moreno,et al.  E2F Activators Signal and Maintain Centrosome Amplification in Breast Cancer Cells , 2014, Molecular and Cellular Biology.

[52]  K. Polyak,et al.  Oncogene-like induction of cellular invasion from centrosome amplification , 2014, Nature.

[53]  Jiyong Liang,et al.  Liver kinase B1 regulates the centrosome via PLK1 , 2014, Cell Death and Disease.

[54]  Jia Luo,et al.  Overexpression of WDR62 is associated with centrosome amplification in human ovarian cancer , 2013, Journal of Ovarian Research.

[55]  A. Krämer,et al.  DNA damage-induced centrosome amplification occurs via excessive formation of centriolar satellites , 2013, Oncogene.

[56]  H. Saavedra,et al.  Cdk4 and Nek2 Signal Binucleation and Centrosome Amplification in a Her2+ Breast Cancer Model , 2013, PloS one.

[57]  P. Rida,et al.  Heading off with the herd: how cancer cells might maneuver supernumerary centrosomes for directional migration , 2013, Cancer and Metastasis Reviews.

[58]  J. Ingle,et al.  Inhibition of Cdk2 activity decreases Aurora-A kinase centrosomal localization and prevents centrosome amplification in breast cancer cells , 2013, Oncology reports.

[59]  F. Hofmann,et al.  Acentrosomal spindle organization renders cancer cells dependent on the kinesin HSET , 2012, Journal of Cell Science.

[60]  A. Krämer,et al.  Centrosome amplification in tumorigenesis. , 2012, Cancer letters.

[61]  A. Krämer,et al.  Overexpression of EVI1 interferes with cytokinesis and leads to accumulation of cells with supernumerary centrosomes in G0/1 phase , 2012, Cell cycle.

[62]  Heinrich Leonhardt,et al.  3D-structured illumination microscopy provides novel insight into architecture of human centrosomes , 2012, Biology Open.

[63]  Oliver Rath,et al.  Kinesins and cancer , 2012, Nature Reviews Cancer.

[64]  P. Rida,et al.  Let's huddle to prevent a muddle: centrosome declustering as an attractive anticancer strategy , 2012, Cell Death and Differentiation.

[65]  T. Furuya,et al.  Centrosome amplification as a putative prognostic biomarker for the classification of urothelial carcinomas. , 2011, Human pathology.

[66]  J. Chan.  A Clinical Overview of Centrosome Amplification in Human Cancers , 2011, International journal of biological sciences.

[67]  F. Westermann,et al.  Cep63 recruits Cdk1 to the centrosome: implications for regulation of mitotic entry, centrosome amplification, and genome maintenance. , 2011, Cancer research.

[68]  I. Hoffmann,et al.  Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome , 2010, The Journal of cell biology.

[69]  W. Nelson,et al.  Formation of extra centrosomal structures is dependent on β-catenin , 2010, Journal of Cell Science.

[70]  D. Cleveland,et al.  Centriole duplication , 2010, Cell cycle.

[71]  S. Duensing,et al.  A novel role of the aryl hydrocarbon receptor (AhR) in centrosome amplification - implications for chemoprevention , 2010, Molecular Cancer.

[72]  K. Hunt,et al.  Low molecular weight cyclin E overexpression shortens mitosis, leading to chromosome missegregation and centrosome amplification. , 2010, Cancer research.

[73]  J. Lloreta,et al.  Centrosome clustering and cyclin D1 gene amplification in double minutes are common events in chromosomal unstable bladder tumors , 2010, BMC Cancer.

[74]  S. Howng,et al.  Differential expression of centrosomal proteins at different stages of human glioma , 2010, BMC Cancer.

[75]  A. Giordano,et al.  Differential expression and cellular distribution of γ‐tubulin and βIII‐tubulin in medulloblastomas and human medulloblastoma cell lines , 2010, Journal of cellular physiology.

[76]  K. Friedrich,et al.  Correlation of centrosomal aberrations with cell differentiation and DNA ploidy in prostate cancer. , 2010, Analytical and quantitative cytology and histology.

[77]  P. Picci,et al.  Centrosome abnormalities in giant cell tumour of bone: possible association with chromosomal instability , 2010, Modern Pathology.

[78]  Ying Gao,et al.  [Expression of TEIF protein in colorectal tumors and its correlation with centrosome abnormality]. , 2009, Ai zheng = Aizheng = Chinese journal of cancer.

[79]  P. Kaldis,et al.  Cdk2 and Cdk4 Regulate the Centrosome Cycle and Are Critical Mediators of Centrosome Amplification in p53-Null Cells , 2009, Molecular and Cellular Biology.

[80]  G. Stark,et al.  Overexpression of kinesins mediates docetaxel resistance in breast cancer cells. , 2009, Cancer research.

[81]  T. Ried,et al.  Nucleation capacity and presence of centrioles define a distinct category of centrosome abnormalities that induces multipolar mitoses in cancer cells , 2009, Environmental and molecular mutagenesis.

[82]  T. Tang,et al.  CPAP is a cell-cycle regulated protein that controls centriole length , 2009, Nature Cell Biology.

[83]  E. Nigg,et al.  Control of Centriole Length by CPAP and CP110 , 2009, Current Biology.

[84]  David Pellman,et al.  A Mechanism Linking Extra Centrosomes to Chromosomal Instability , 2009, Nature.

[85]  Ying Sun,et al.  Localization of TEIF in the centrosome and its functional association with centrosome amplification in DNA damage, telomere dysfunction and human cancers , 2009, Oncogene.

[86]  Z. Ram,et al.  The Expression of Three Genes in Primary Non–Small Cell Lung Cancer Is Associated with Metastatic Spread to the Brain , 2009, Clinical Cancer Research.

[87]  Y. Miyoshi,et al.  Association of loss of BRCA1 expression with centrosome aberration in human breast cancer , 2009, Journal of Cancer Research and Clinical Oncology.

[88]  J. Loncarek,et al.  Ab ovo or de novo? Mechanisms of centriole duplication , 2009, Molecules and cells.

[89]  D. Pellman,et al.  Centrosomes and cancer: how cancer cells divide with too many centrosomes , 2009, Cancer and Metastasis Reviews.

[90]  A. Boulesteix,et al.  Centrosome abnormalities in head and neck squamous cell carcinoma (HNSCC) , 2009, Acta oto-laryngologica.

[91]  B. Rosen,et al.  Distinct patterns of structural and numerical chromosomal instability characterize sporadic ovarian cancer. , 2008, Neoplasia.

[92]  M. Kanai,et al.  Roles of cyclins A and E in induction of centrosome amplification in p53-compromised cells , 2008, Oncogene.

[93]  S. Lens,et al.  The Aurora kinase family in cell division and cancer. , 2008, Biochimica et biophysica acta.

[94]  D. Pellman,et al.  Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. , 2008, Genes & development.

[95]  E. Galanis,et al.  Impaired p53 function leads to centrosome amplification, acquired ERα phenotypic heterogeneity and distant metastases in breast cancer MCF-7 xenografts , 2008, Oncogene.

[96]  Alexey Khodjakov,et al.  Centrosome Amplification Can Initiate Tumorigenesis in Flies , 2008, Cell.

[97]  J. Loncarek,et al.  Control of daughter centriole formation by the pericentriolar material , 2008, Nature Cell Biology.

[98]  S. Duensing,et al.  Analysis of centrosome overduplication in correlation to cell division errors in high-risk human papillomavirus (HPV)-associated anal neoplasms. , 2008, Virology.

[99]  S. Prime,et al.  Spindle assembly checkpoint and centrosome abnormalities in oral cancer. , 2007, Cancer letters.

[100]  C. Kang,et al.  Centrosome abnormalities in non-small cell lung cancer: correlations with DNA aneuploidy and expression of cell cycle regulatory proteins. , 2007, Pathology, research and practice.

[101]  Y. Liu,et al.  Centriole overduplication through the concurrent formation of multiple daughter centrioles at single maternal templates , 2007, Oncogene.

[102]  A. Jauch,et al.  High rate of centrosome aberrations and correlation with proliferative activity in patients with untreated B‐cell chronic lymphocytic leukemia , 2007, International journal of cancer.

[103]  Sebastian A. Leidel,et al.  Regulated HsSAS-6 levels ensure formation of a single procentriole per centriole during the centrosome duplication cycle. , 2007, Developmental cell.

[104]  Yan-ning Gao,et al.  Analysis of the cellular centrosome in fine-needle aspirations of the breast , 2007, Breast Cancer Research.

[105]  A. Sood,et al.  Overexpression of the Centrosomal Protein Aurora-A Kinase is Associated with Poor Prognosis in Epithelial Ovarian Cancer Patients , 2007, Clinical Cancer Research.

[106]  A. Rosenwald,et al.  Expression of centrosome‐associated gene products is linked to tetraploidization in mantle cell lymphoma , 2007, International journal of cancer.

[107]  Hideyasu Matsuyama,et al.  Overexpression of BUBR1 is associated with chromosomal instability in bladder cancer. , 2007, Cancer genetics and cytogenetics.

[108]  B. Delaval,et al.  Loss of centrosome integrity induces p38—p53—p21-dependent G1—S arrest , 2007, Nature Cell Biology.

[109]  Y. Liu,et al.  RNA polymerase II transcription is required for human papillomavirus type 16 E7- and hydroxyurea-induced centriole overduplication , 2007, Oncogene.

[110]  E. Nigg,et al.  Origins and consequences of centrosome aberrations in human cancers , 2006, International journal of cancer.

[111]  Peter Gais,et al.  Aurora Kinase A Messenger RNA Overexpression Is Correlated with Tumor Progression and Shortened Survival in Head and Neck Squamous Cell Carcinoma , 2006, Clinical Cancer Research.

[112]  T. Stearns,et al.  Mechanism limiting centrosome duplication to once per cell cycle , 2006, Nature.

[113]  T. Hackstadt,et al.  Chlamydia trachomatis Causes Centrosomal Defects Resulting in Chromosomal Segregation Abnormalities , 2006, Traffic.

[114]  J. Bartek,et al.  Centrosome abnormalities are frequently observed in non‐small‐cell lung cancer and are associated with aneuploidy and cyclin E overexpression , 2006, The Journal of pathology.

[115]  T. Furuya,et al.  Overexpression of Polo-Like Kinase 1 (PLK1) and Chromosomal Instability in Bladder Cancer , 2006, Oncology.

[116]  T. Maraziotis,et al.  Altered Cellular Distribution and Subcellular Sorting of &ggr;-Tubulin in Diffuse Astrocytic Gliomas and Human Glioblastoma Cell Lines , 2006, Journal of neuropathology and experimental neurology.

[117]  G. Ahmann,et al.  Clinical implication of centrosome amplification in plasma cell neoplasm. , 2006, Blood.

[118]  Hideyasu Matsuyama,et al.  Biological Characteristics in Bladder Cancer Depend on the Type of Genetic Instability , 2006, Clinical Cancer Research.

[119]  A. Ryo,et al.  Pin1 Regulates Centrosome Duplication, and Its Overexpression Induces Centrosome Amplification, Chromosome Instability, and Oncogenesis , 2006, Molecular and Cellular Biology.

[120]  Y. Lazebnik,et al.  A primate virus generates transformed human cells by fusion , 2005, The Journal of cell biology.

[121]  Christopher J. Wilkinson,et al.  The Polo kinase Plk4 functions in centriole duplication , 2005, Nature Cell Biology.

[122]  M. Hafner,et al.  Centrosome aberrations in chronic myeloid leukemia correlate with stage of disease and chromosomal instability , 2005, Leukemia.

[123]  V. Yang,et al.  Krüppel-like factor 4 prevents centrosome amplification following γ-irradiation-induced DNA damage , 2005, Oncogene.

[124]  Klaus Kayser,et al.  Numerical and structural centrosome aberrations are an early and stable event in the adenoma–carcinoma sequence of colorectal carcinomas , 2005, Virchows Archiv.

[125]  A. Krämer,et al.  Centrosome aberrations in hematological malignancies , 2005, Cell biology international.

[126]  B. McEwen,et al.  The de novo centriole assembly pathway in HeLa cells: cell cycle progression and centriole assembly/maturation. , 2005, The Journal of cell biology.

[127]  J. Deloia,et al.  Centrosome abnormalities in ovarian cancer , 2005, International journal of cancer.

[128]  T. Ried,et al.  Characterisation of breast fine-needle aspiration biopsies by centrosome aberrations and genomic instability , 2004, British Journal of Cancer.

[129]  Hideyasu Matsuyama,et al.  Centrosome Hyperamplification Predicts Progression and Tumor Recurrence in Bladder Cancer , 2004, Clinical Cancer Research.

[130]  Steven P. Gygi,et al.  BRCA1-Dependent Ubiquitination of γ-Tubulin Regulates Centrosome Number , 2004, Molecular and Cellular Biology.

[131]  Takayuki Nojima,et al.  Induction of Centrosome Amplification and Chromosome Instability in Human Bladder Cancer Cells by p53 Mutation and Cyclin E Overexpression , 2004, Cancer Research.

[132]  Y. Mitsumoto,et al.  Centrosome aberration accompanied with p53 mutation can induce genetic instability in hepatocellular carcinoma , 2004, Modern Pathology.

[133]  Qian-ming Cheng,et al.  [Centrosome hyperamplificationin oral precancerous lesions and squamous cell carcinomas]. , 2004, Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology.

[134]  D. Gisselsson,et al.  Telomere shortening and mitotic dysfunction generate cytogenetic heterogeneity in a subgroup of renal cell carcinomas , 2004, British Journal of Cancer.

[135]  Christina Y. Yu,et al.  Mitotic instability associated with late genomic changes in bone and soft tissue tumours. , 2004, Cancer letters.

[136]  J. Grosgeorge,et al.  Distinct MDM2 and P14ARF expression and centrosome amplification in well‐differentiated liposarcomas , 2004, Genes, chromosomes & cancer.

[137]  J. Salisbury.  Centrosomes: Sfi1p and Centrin Unravel a Structural Riddle , 2004, Current Biology.

[138]  S. Lippman,et al.  Loss of aurora A/STK15/BTAK overexpression correlates with transition of in situ to invasive ductal carcinoma of the breast. , 2003, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

[139]  A. Schneeweiss,et al.  Centrosomal aberrations in primary invasive breast cancer are associated with nodal status and hormone receptor expression , 2003, International journal of cancer.

[140]  A. Sabichi,et al.  Centrosomal abnormality is common in and a potential biomarker for bladder cancer , 2003, International journal of cancer.

[141]  S. Sen,et al.  Aneuploidy of human testicular germ cell tumors is associated with amplification of centrosomes , 2003, Oncogene.

[142]  H. Kampinga,et al.  Centrosomes split in the presence of impaired DNA integrity during mitosis. , 2003, Molecular biology of the cell.

[143]  T. Nojima,et al.  Centrosome hyperamplification and chromosomal instability in bladder cancer. , 2003, European urology.

[144]  G. Pihan,et al.  Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomas. , 2003, Cancer research.

[145]  C. Rieder,et al.  De novo formation of centrosomes in vertebrate cells arrested during S phase , 2002, The Journal of cell biology.

[146]  W. Lingle,et al.  Centrosome amplification and the development of cancer , 2002, Oncogene.

[147]  F. Stivala,et al.  Amplified Centrosomes in Breast Cancer: A Potential Indicator of Tumor Aggressiveness , 2002, Breast Cancer Research and Treatment.

[148]  R. Margolis,et al.  Multiple centrosomes arise from tetraploidy checkpoint failure and mitotic centrosome clusters in p53 and RB pocket protein-compromised cells , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[149]  D. Gisselsson,et al.  Centrosomal abnormalities, multipolar mitoses, and chromosomal instability in head and neck tumours with dysfunctional telomeres , 2002, British Journal of Cancer.

[150]  C. Larsson,et al.  Aberrations of centrosomes in adrenocortical tumors. , 2002, International journal of oncology.

[151]  H. Heng,et al.  Rad6 overexpression induces multinucleation, centrosome amplification, abnormal mitosis, aneuploidy, and transformation. , 2002, Cancer research.

[152]  P. Meraldi,et al.  Aurora‐A overexpression reveals tetraploidization as a major route to centrosome amplification in p53−/− cells , 2002, The EMBO journal.

[153]  Carol Reynolds,et al.  Centrosome amplification drives chromosomal instability in breast tumor development , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[154]  M. Bornens.  Centrosome composition and microtubule anchoring mechanisms. , 2002, Current opinion in cell biology.

[155]  K. Münger,et al.  Centrosome Abnormalities and Genomic Instability by Episomal Expression of Human Papillomavirus Type 16 in Raft Cultures of Human Keratinocytes , 2001, Journal of Virology.

[156]  G. Auer,et al.  Human Papillomavirus Infection, Centrosome Aberration, and Genetic Stability in Cervical Lesions , 2001, Modern Pathology.

[157]  L. Liotta,et al.  Centrosome defects can account for cellular and genetic changes that characterize prostate cancer progression. , 2001, Cancer research.

[158]  K. Münger,et al.  Human papillomavirus type 16 E7 oncoprotein-induced abnormal centrosome synthesis is an early event in the evolving malignant phenotype. , 2001, Cancer research.

[159]  A. Khodjakov,et al.  Requirement of a Centrosomal Activity for Cell Cycle Progression Through G1 into S Phase , 2001, Science.

[160]  K. Fukasawa,et al.  Centrosome Hyperamplification in Head and Neck Squamous Cell Carcinoma: A Potential Phenotypic Marker of Tumor Aggressiveness , 2000, The Laryngoscope.

[161]  K. Münger,et al.  The human papillomavirus type 16 E6 and E7 oncoproteins cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[162]  E. Schröck,et al.  Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations , 2000, Genes, chromosomes & cancer.

[163]  C. Ker,et al.  Centrosome abnormalities in human carcinomas of the gallbladder and intrahepatic and extrahepatic bile ducts , 2000, Hepatology.

[164]  W. Lingle,et al.  Altered centrosome structure is associated with abnormal mitoses in human breast tumors. , 1999, The American journal of pathology.

[165]  Masafumi Nakamura,et al.  Centrosome abnormalities in pancreatic ductal carcinoma. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

[166]  Patrick E Carroll,et al.  Centrosome hyperamplification in human cancer: chromosome instability induced by p53 mutation and/or Mdm2 overexpression , 1999, Oncogene.

[167]  H Knecht,et al.  Centrosome defects and genetic instability in malignant tumors. , 1998, Cancer research.

[168]  J. Ingle,et al.  Centrosome hypertrophy in human breast tumors: implications for genomic stability and cell polarity. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[169]  M. Kirschner,et al.  Pericentrin, a highly conserved centrosome protein involved in microtubule organization , 1994, Cell.

[170]  G. Hamoir,et al.  The discovery of meiosis by E. Van Beneden, a breakthrough in the morphological phase of heredity. , 1992, The International journal of developmental biology.

[171]  M. Kirschner,et al.  γ-Tubulin is a highly conserved component of the centrosome , 1991, Cell.

[172]  M. Kirschner,et al.  Beyond self-assembly: From microtubules to morphogenesis , 1986, Cell.

[173]  R. Kuriyama,et al.  Microtubule-organizing centers abnormal in number, structure, and nucleating activity in x-irradiated mammalian cells , 1983, The Journal of cell biology.

[174]  I. Vorobjev,et al.  The ultrastructure of centriole in mammalian tissue culture cells. , 1980, Cell biology international reports.

[175]  A. Levis,et al.  INDUCTION OF MULTIPOLAR SPINDLES BY X-RADIATION IN MAMMALIAN CELLS IN VITRO. , 1963, Experimental cell research.

[176]  Xin Chen,et al.  Cyclin A2 regulates symmetrical mitotic spindle formation and centrosome amplification in human colon cancer cells. , 2018, American journal of translational research.

[177]  N. Oue,et al.  KIFC1 induces resistance to docetaxel and is associated with survival of patients with prostate cancer. , 2017, Urologic oncology.

[178]  Yoshiaki Yamamoto,et al.  Centrosome amplification in bladder washing cytology specimens is a useful prognostic biomarker for non-muscle invasive bladder cancer. , 2013, Cancer genetics.

[179]  H. Sugimura,et al.  Suppression of hydroxyurea-induced centrosome amplification by NORE1A and down-regulation of NORE1A mRNA expression in non-small cell lung carcinoma. , 2011, Lung cancer.

[180]  Y. Tsunematsu,et al.  Centrosome amplification is correlated with ploidy divergence, but not with MYCN amplification, in neuroblastoma tumors. , 2009, Cancer genetics and cytogenetics.

[181]  V. Yang,et al.  Krüppel-like factor 4 prevents centrosome amplification following gamma-irradiation-induced DNA damage. , 2005, Oncogene.

[182]  Joshua E. Elias,et al.  BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number. , 2004, Molecular and cellular biology.

[183]  A. Krämer,et al.  Centrosome aberrations in acute myeloid leukemia are correlated with cytogenetic risk profile. , 2003, Blood.

[184]  H. Müller-Hermelink,et al.  Centrosome aberrations as a possible mechanism for chromosomal instability in non-Hodgkin's lymphoma , 2003, Leukemia.

[185]  A. Venkitaraman,et al.  AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol. , 2003, Cancer cell.

[186]  Theodor Boveri.  Ueber den Antheil des Spermatozoon an der Theilung des Eies , 1887 .

[187]  Édouard Van Beneden,et al.  Nouvelles recherches sur la fécondation et la division mitosique chez l’ascaride mégalocéphale , 1887 .