Effect of Frail Phenotype on Bone Mass and Vertebral Compression Fracture in Individuals Undergoing Dialysis

rehospitalization. Of participants with delirium onset within 72 hours, all-cause death and rehospitalization rates were not significantly more frequent, and the composite end-point (n = 28, 71.8%) was significantly more frequent than in other participants (n = 102, 28.2%) (P < .001). Delirium occurrence within 72 hours (odds ratio (OR) = 1.43, 95% confidence interval (CI) = 1.13– 1.67), functional dependence (OR = 1.37, 95% CI = 1.05–1.71), greater Cumulative Illness Rating Scale severity (OR = 1.18, 95% CI = 1.08–1.89), low hematocrit (OR = 0.79, 95% CI = 0.53–0.98) and serum albumin levels (OR = 0.69, 95% CI = 0.38–0.97) were significantly associated with greater incidence of the composite end-point. These results provide evidence that individuals who experience delirium within 72 hours after ward admission have a greater risk of death and rehospitalization; the association between delirium occurrence and the composite end-point remained significant after multivariate adjustment. In keeping with previous studies that have reported greater postdischarge mortality and worse clinical outcomes in individuals who develop delirium during a hospital stay, these findings add to the current evidence demonstrating that ED length of stay, by increasing the risk of delirium onset, might contribute to postdischarge death and rehospitalizations. Therefore, whether interventions designed to shorten the length of ED stay (or to make it more comfortable) may reduce the incidence of delirium in older vulnerable adults and result in a better overall prognosis, including lower mortality and rehospitalization rates, should be evaluated.