Adhesion protein networks reveal functions proximal and distal to cell-matrix contacts

[1]  M. Humphries,et al.  Characterization of the Phospho-Adhesome by Mass Spectrometry-Based Proteomics. , 2017, Methods in molecular biology.

[2]  M. Humphries,et al.  Mechanosensitivity of integrin adhesion complexes: role of the consensus adhesome. , 2016, Experimental cell research.

[3]  V. Hytönen,et al.  Mechanosensing in cell-matrix adhesions - Converting tension into chemical signals. , 2016, Experimental cell research.

[4]  M. Frame,et al.  A direct interaction between fascin and microtubules contributes to adhesion dynamics and cell migration , 2015, Journal of Cell Science.

[5]  M. Sheetz,et al.  Nascent Integrin Adhesions Form on All Matrix Rigidities after Integrin Activation. , 2015, Developmental cell.

[6]  Pengbo Wang,et al.  Vinculin controls talin engagement with the actomyosin machinery , 2015, Nature Communications.

[7]  P. McCrea,et al.  Beyond β-catenin: prospects for a larger catenin network in the nucleus , 2015, Nature Reviews Molecular Cell Biology.

[8]  Jing Zhou,et al.  Mechanism of Focal Adhesion Kinase Mechanosensing , 2015, PLoS Comput. Biol..

[9]  M. Rief,et al.  Extracellular rigidity sensing by talin isoform–specific mechanical linkages , 2015, Nature Cell Biology.

[10]  Alexia I. Bachir,et al.  A RIAM/lamellipodin–talin–integrin complex forms the tip of sticky fingers that guide cell migration , 2015, Nature Communications.

[11]  Adam Byron,et al.  Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity , 2015, Cell.

[12]  Adam Byron,et al.  Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly , 2015, Nature Cell Biology.

[13]  S. Strömblad,et al.  A plastic relationship between vinculin-mediated tension and adhesion complex area defines adhesion size and lifetime , 2015, Nature Communications.

[14]  Michelle R. Dawson,et al.  Alterations in Ovarian Cancer Cell Adhesion Drive Taxol Resistance by Increasing Microtubule Dynamics in a FAK-dependent Manner , 2015, Scientific Reports.

[15]  J. P. Fawcett,et al.  Synaptopodin-2 induces assembly of peripheral actin bundles and immature focal adhesions to promote lamellipodia formation and prostate cancer cell migration , 2015, Oncotarget.

[16]  M. Humphries,et al.  Isolation of Integrin‐Based Adhesion Complexes , 2015, Current protocols in cell biology.

[17]  Julian N. Selley,et al.  Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling , 2015, Nature Communications.

[18]  Colin K. Choi,et al.  A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting , 2015, Nature Communications.

[19]  M. Humphries,et al.  Microtubule-Dependent Modulation of Adhesion Complex Composition , 2014, PloS one.

[20]  M. Xie,et al.  Microtubules regulate focal adhesion dynamics through MAP4K4. , 2014, Developmental cell.

[21]  Guillaume Charras,et al.  Physical influences of the extracellular environment on cell migration , 2014, Nature Reviews Molecular Cell Biology.

[22]  V. Galkin,et al.  Septins promote stress fiber–mediated maturation of focal adhesions and renal epithelial motility , 2014, The Journal of cell biology.

[23]  P. Skourides,et al.  FAK transduces extracellular forces that orient the mitotic spindle and control tissue morphogenesis , 2014, Nature Communications.

[24]  E. Gratton,et al.  Integrin-Associated Complexes Form Hierarchically with Variable Stoichiometry in Nascent Adhesions , 2014, Current Biology.

[25]  J. Lasheras,et al.  FAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells , 2014, Scientific Reports.

[26]  Yong Ho Bae,et al.  A FAK-Cas-Rac-Lamellipodin Signaling Module Transduces Extracellular Matrix Stiffness into Mechanosensitive Cell Cycling , 2014, Science Signaling.

[27]  Katja Ickstadt,et al.  Symmetric exchange of multi-protein building blocks between stationary focal adhesions and the cytosol , 2014, eLife.

[28]  Samantha J. Stehbens,et al.  CLASPs link focal adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover , 2014, Nature Cell Biology.

[29]  Jie Yan,et al.  Mechanical activation of vinculin binding to talin locks talin in an unfolded conformation , 2014, Scientific Reports.

[30]  B. Geiger,et al.  The integrin adhesome: from genes and proteins to human disease , 2014, Nature Reviews Molecular Cell Biology.

[31]  Jean-Antoine Girault,et al.  FAK dimerization controls its kinase‐dependent functions at focal adhesions , 2014, The EMBO journal.

[32]  M. Sheetz,et al.  FHOD1 is needed for directed forces and adhesion maturation during cell spreading and migration. , 2013, Developmental cell.

[33]  V. Brunton,et al.  Kindlin-1 regulates mitotic spindle formation by interacting with integrins and Plk-1 , 2013, Nature Communications.

[34]  M. Mann,et al.  β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments , 2013, Nature Cell Biology.

[35]  Adam Byron,et al.  Defining the extracellular matrix using proteomics , 2013, International journal of experimental pathology.

[36]  Alexandra M. Greiner,et al.  Vinculin Regulates the Recruitment and Release of Core Focal Adhesion Proteins in a Force-Dependent Manner , 2013, Current Biology.

[37]  Tamar Geiger,et al.  Opening the floodgates: proteomics and the integrin adhesome. , 2012, Current opinion in cell biology.

[38]  M. Humphries,et al.  Alternative cellular roles for proteins identified using proteomics. , 2012, Journal of proteomics.

[39]  M. Humphries,et al.  Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment , 2012, Proteomics.

[40]  S. Lim,et al.  Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression , 2012, The Journal of cell biology.

[41]  M. Longaker,et al.  Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling , 2011, Nature Medicine.

[42]  Benjamin Geiger,et al.  Molecular architecture and function of matrix adhesions. , 2011, Cold Spring Harbor perspectives in biology.

[43]  M. Humphries,et al.  Proteomic Analysis of Integrin Adhesion Complexes , 2011, Science Signaling.

[44]  John R. Yates,et al.  Analysis of the myosinII-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation , 2011, Nature Cell Biology.

[45]  H. Schiller,et al.  Quantitative proteomics of the integrin adhesome show a myosin II‐dependent recruitment of LIM domain proteins , 2011, EMBO reports.

[46]  M. Humphries,et al.  Adhesion signalling complexes , 2010, Current Biology.

[47]  Richard O. Hynes,et al.  The Extracellular Matrix: Not Just Pretty Fibrils , 2009, Science.

[48]  Adam Byron,et al.  Proteomic Analysis of Integrin-Associated Complexes Identifies RCC2 as a Dual Regulator of Rac1 and Arf6 , 2009, Science Signaling.

[49]  L. Mei,et al.  Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2 , 2009, The EMBO journal.

[50]  Adam J Engler,et al.  Multiscale Modeling of Form and Function , 2009, Science.

[51]  S. LaFlamme,et al.  Integrins as regulators of the mitotic machinery. , 2008, Current opinion in cell biology.

[52]  Kenneth M. Yamada,et al.  Faculty Opinions recommendation of Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner. , 2008, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.

[53]  Susan J Fisher,et al.  Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. , 2008, Molecular cell.

[54]  S. Itzkovitz,et al.  Functional atlas of the integrin adhesome , 2007, Nature Cell Biology.

[55]  Adam Byron,et al.  Integrin ligands at a glance , 2006, Journal of Cell Science.

[56]  M. Beckerle,et al.  From the membrane to the nucleus and back again: bifunctional focal adhesion proteins. , 2006, Current opinion in cell biology.

[57]  V. Golubovskaya,et al.  Direct Interaction of the N-terminal Domain of Focal Adhesion Kinase with the N-terminal Transactivation Domain of p53* , 2005, Journal of Biological Chemistry.

[58]  M. Beckerle,et al.  The LIM domain: from the cytoskeleton to the nucleus , 2004, Nature Reviews Molecular Cell Biology.

[59]  Z. Kam,et al.  Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells , 2003, Journal of Cell Science.

[60]  M. Roberts,et al.  Paxillin Associates with Poly(A)-binding Protein 1 at the Dense Endoplasmic Reticulum and the Leading Edge of Migrating Cells* , 2002, The Journal of Biological Chemistry.

[61]  I. Zachary,et al.  Nuclear localization and apoptotic regulation of an amino-terminal domain focal adhesion kinase fragment in endothelial cells. , 2000, Biochemical and biophysical research communications.

[62]  Donald E. Ingber,et al.  Integrin binding and mechanical tension induce movement of mRNA and ribosomes to focal adhesions , 1998, Nature.

[63]  Hitoshi Tsuda,et al.  Actinin-4, a Novel Actin-bundling Protein Associated with Cell Motility and Cancer Invasion , 1998, The Journal of cell biology.

[64]  David A. Nix,et al.  Nuclear–Cytoplasmic Shuttling of the Focal Contact Protein, Zyxin: A Potential Mechanism for Communication between Sites of Cell Adhesion and the Nucleus , 1997, The Journal of cell biology.

[65]  J. Yates,et al.  Isolation of focal adhesion proteins for biochemical and proteomic analysis. , 2012, Methods in molecular biology.