Modulation of the slow/common gating of CLC channels by intracellular cadmium

Cd2+ binding to the CLC channel dimer interface inhibits slow gating by altering subunit interactions.

[1]  Tsung-Yu Chen,et al.  Elimination of the Slow Gating of Clc-0 Chloride Channel by a Point Mutation , 1999, The Journal of general physiology.

[2]  Tobias Stauber,et al.  Cell biology and physiology of CLC chloride channels and transporters. , 2012, Comprehensive Physiology.

[3]  C. Kubisch,et al.  ClC-1 chloride channel mutations in myotonia congenita: variable penetrance of mutations shifting the voltage dependence. , 1998, Human molecular genetics.

[4]  Christopher Miller,et al.  Homodimeric architecture of a CIC-type chloride ion channel , 1996, Nature.

[5]  Thomas J. Jentsch,et al.  Two physically distinct pores in the dimeric CIC-0 chloride channel , 1996, Nature.

[6]  Liang Feng,et al.  Structure of a Eukaryotic CLC Transporter Defines an Intermediate State in the Transport Cycle , 2010, Science.

[7]  Labeling of specific cysteines in proteins using reversible metal protection. , 2011, Biophysical journal.

[8]  Jie Zheng,et al.  Large movement in the C terminus of CLC-0 chloride channel during slow gating , 2006, Nature Structural &Molecular Biology.

[9]  C. Miller.  Open-state substructure of single chloride channels from Torpedo electroplax. , 1982, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[10]  J. Mindell,et al.  A decade of CLC chloride channels: structure, mechanism, and many unsettled questions. , 2000, Annual review of biophysics and biomolecular structure.

[11]  Tsung-Yu Chen,et al.  ATP Inhibition of CLC-1 Is Controlled by Oxidation and Reduction , 2008, The Journal of general physiology.

[12]  Christopher Miller,et al.  Purification, reconstitution, and subunit composition of a voltage-gated chloride channel from Torpedo electroplax. , 1994, Biochemistry.

[13]  Tsung-Yu Chen,et al.  Probing the Pore of ClC-0 by Substituted Cysteine Accessibility Method Using Methane Thiosulfonate Reagents , 2003, The Journal of general physiology.

[14]  R. Tsien,et al.  Monitoring protein conformations and interactions by fluorescence resonance energy transfer between mutants of green fluorescent protein. , 2000, Methods in enzymology.

[15]  C. Miller,et al.  Dimeric structure of single chloride channels from Torpedo electroplax. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[16]  Ludmila Kolmakova-Partensky,et al.  Design, function, and structure of a monomeric CLC transporter , 2010, Nature.

[17]  Tsung-Yu Chen.  Extracellular Zinc Ion Inhibits ClC-0 Chloride Channels by Facilitating Slow Gating , 1998, The Journal of general physiology.

[18]  M. Parker,et al.  Molecular determinants of common gating of a ClC chloride channel , 2013, Nature Communications.

[19]  R. Estévez,et al.  CLC chloride channels: correlating structure with function. , 2002, Current opinion in structural biology.

[20]  Accessibility of the CLC-0 pore to charged methanethiosulfonate reagents. , 2010, Biophysical journal.

[21]  D Sodickson,et al.  An engineered cysteine in the external mouth of a K+ channel allows inactivation to be modulated by metal binding. , 1994, Biophysical journal.

[22]  T. Jentsch,et al.  CLC Chloride Channels and Transporters: From Genes to Protein Structure, Pathology and Physiology , 2008, Critical reviews in biochemistry and molecular biology.

[23]  F. Conti,et al.  The Muscle Chloride Channel ClC-1 Has a Double-Barreled Appearance that Is Differentially Affected in Dominant and Recessive Myotonia , 1999, The Journal of general physiology.

[24]  M. Trudeau,et al.  Rod Cyclic Nucleotide-Gated Channels Have a Stoichiometry of Three CNGA1 Subunits and One CNGB1 Subunit , 2002, Neuron.

[25]  R. Dutzler,et al.  X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity , 2002, Nature.

[26]  Jie Zheng,et al.  Disruption of an Intersubunit Interaction Underlies Ca2+-Calmodulin Modulation of Cyclic Nucleotide-Gated Channels , 2003, The Journal of Neuroscience.

[27]  D. T. Yue,et al.  Preassociation of Calmodulin with Voltage-Gated Ca2+ Channels Revealed by FRET in Single Living Cells , 2001, Neuron.

[28]  Tsung-Yu Chen,et al.  Structure and function of clc channels. , 2005, Annual review of physiology.

[29]  A. George,et al.  Pore stoichiometry of a voltage-gated chloride channel , 1998, Nature.

[30]  T. Jentsch,et al.  CLC chloride channels and transporters , 2005, Current Opinion in Neurobiology.

[31]  Tsung-Yu Chen,et al.  Cytoplasmic ATP Inhibition of CLC-1 Is Enhanced by Low pH , 2007, The Journal of general physiology.

[32]  Roderick MacKinnon,et al.  Gating the Selectivity Filter in ClC Chloride Channels , 2003, Science.

[33]  L. Rulíšek,et al.  Coordination geometries of selected transition metal ions (Co2+, Ni2+, Cu2+, Zn2+, Cd2+, and Hg2+) in metalloproteins. , 1998, Journal of inorganic biochemistry.

[34]  Michael Duffield,et al.  Involvement of Helices at the Dimer Interface in ClC-1 Common Gating , 2003, The Journal of general physiology.

[35]  A. Accardi,et al.  Fast and Slow Gating Relaxations in the Muscle Chloride Channel Clc-1 , 2000, The Journal of general physiology.

[36]  Christopher Miller,et al.  CLC Cl−/H+ transporters constrained by covalent cross-linking , 2007, Proceedings of the National Academy of Sciences.

[37]  Amphiphilic Blockers Punch through a Mutant CLC-0 Pore , 2009, The Journal of general physiology.

[38]  M. Koch,et al.  Mutations in dominant human myotonia congenita drastically alter the voltage dependence of the CIC-1 chloride channel , 1995, Neuron.

[39]  B. P. Hughes,et al.  pH‐Dependent Interactions of Cd2+ and a Carboxylate Blocker with the Rat ClC‐1 Chloride Channel and Its R304E Mutant in the Sf‐9 Insect Cell Line , 1997, The Journal of physiology.

[40]  Tsung-Yu Chen,et al.  Roles of K149, G352, and H401 in the Channel Functions of ClC-0: Testing the Predictions from Theoretical Calculations , 2006, The Journal of general physiology.

[41]  M. Parker,et al.  Cytoplasmic ATP-sensing Domains Regulate Gating of Skeletal Muscle ClC-1 Chloride Channels* , 2005, Journal of Biological Chemistry.

[42]  G. Yellen,et al.  The Activation Gate of a Voltage-Gated K+ Channel Can Be Trapped in the Open State by an Intersubunit Metal Bridge , 1998, Neuron.