Biochemical networking contributes more to genetic buffering in human and mouse metabolic pathways than does gene duplication

Nature Genet. 32, 191–194 (2002). Published online 5 August 2002; doi:10.1038/ng945 To the authors' dismay, a software bug adversely affected some but not all of the main conclusions of this article. They reported that redundant biochemical networks provide greater genetic buffering than do gene families, on the basis of the rate of gene evolution for genes in the glycolysis/gluconeogenesis and the folate/homocysteine pathways.