The Potential Anti-inflammatory and Wound Healing Activities of Chitosan in rats

In the current investigation, the anti-inflammatory and wound healing potential of chitosan were investigated. To expose the anti-inflammatory effect of chitosan, we studied its effect against edema induced by carrageenanin rat foot pad at 150 and 300 mg/ kg and compared with the reference, indomethacin (5 mg/kg). The wound healing effect of chitosan was evaluated in rats by excision method and compared with the standard, fucidine cream 2%. The wound-healing activity was assessed by the rate of wound contraction and period of epithelialization. Our results showed that oral administration of chitosan at 150 and 300 mg/ kg to rats reduced carrageenan-induced edema dose-dependently.In assessing wound healing effect, topical application of 5% and 10% chitosan creams accelerated healing of wounds when compared to control.The rate of wound contraction was significantly increased on days 3 21in fucidine and chitosan (5 and 10%)-treated animals. The duration of wound epithelialization was decreased in groups treated with the reference standard and chitosan creams than the vehicle-treated group. These results strongly document the beneficial effects of chitosanas anti-inflammatory and for the precipitation of wound healing in rats.