EGCG inhibits growth of human pancreatic tumors orthotopically implanted in Balb C nude mice through modulation of FKHRL1/FOXO3a and neuropilin

[1]  A. Abioye,et al.  Pancreatic carcinoma. , 2020, Journal of the National Medical Association.

[2]  Duane H. Hamilton,et al.  Influence of IL-8 on the epithelial-mesenchymal transition and the tumor microenvironment. , 2012, Future oncology.

[3]  S. Shankar,et al.  Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics , 2012, International journal of cancer.

[4]  S. Shankar,et al.  EGCG Enhances the Therapeutic Potential of Gemcitabine and CP690550 by Inhibiting STAT3 Signaling Pathway in Human Pancreatic Cancer , 2012, PloS one.

[5]  S. Shankar,et al.  Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications. , 2011, Biochemical pharmacology.

[6]  S. Roy,et al.  Resveratrol Inhibits Growth of Orthotopic Pancreatic Tumors through Activation of FOXO Transcription Factors , 2011, PloS one.

[7]  Marianne D. Castillo,et al.  IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells. , 2011, Cancer research.

[8]  Hong Wang,et al.  Mechanistic issues concerning cancer prevention by tea catechins. , 2011, Molecular nutrition & food research.

[9]  M. Klagsbrun,et al.  Hypoxia induces tumor and endothelial cell migration in a Semaphorin 3F- and VEGF-dependent manner via transcriptional repression of their common receptor Neuropilin 2 , 2011, Cell adhesion & migration.

[10]  G. Rimbach,et al.  Epicatechin gallate and catechin gallate are superior to epigallocatechin gallate in growth suppression and anti‐inflammatory activities in pancreatic tumor cells , 2011, Cancer science.

[11]  K. Pavelić,et al.  Metastasis: new perspectives on an old problem , 2011, Molecular Cancer.

[12]  I. Ohdomari,et al.  Green Tea Epigallocatechin Gallate Exhibits Anticancer Effect in Human Pancreatic Carcinoma Cells via the Inhibition of Both Focal Adhesion Kinase and Insulin-Like Growth Factor-I Receptor , 2011, Journal of biomedicine & biotechnology.

[13]  Sharmila Shankar,et al.  Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer , 2010, Journal of molecular signaling.

[14]  G. Pani,et al.  Metastasis: cancer cell’s escape from oxidative stress , 2010, Cancer and Metastasis Reviews.

[15]  S. Shankar,et al.  FOXO transcription factors and VEGF neutralizing antibody enhance antiangiogenic effects of resveratrol , 2010, Molecular and Cellular Biochemistry.

[16]  J. Au,et al.  Pancreatic Cancer: Pathobiology, Treatment Options, and Drug Delivery , 2010, The AAPS Journal.

[17]  R. Kurzrock,et al.  Sulforaphane inhibits angiogenesis through activation of FOXO transcription factors. , 2009, Oncology reports.

[18]  N. McCarthy.  Metastasis: Route master , 2009, Nature Reviews Cancer.

[19]  N. McCarthy.  Metastasis: Influencing bad behaviour , 2009, Nature Reviews Cancer.

[20]  Xin Wang,et al.  Cancer prevention by tea: animal studies, molecular mechanisms and human relevance , 2009, Nature Reviews Cancer.

[21]  Paula D. Bos,et al.  Metastasis: from dissemination to organ-specific colonization , 2009, Nature Reviews Cancer.

[22]  E. Lam,et al.  BH3-only protein Bim more critical than Puma in tyrosine kinase inhibitor-induced apoptosis of human leukemic cells and transduced hematopoietic progenitors carrying oncogenic FLT3. , 2009, Blood.

[23]  L. Ellis,et al.  Neuropilin-2–Mediated Tumor Growth and Angiogenesis in Pancreatic Adenocarcinoma , 2008, Clinical Cancer Research.

[24]  W. Fisher,et al.  Interleukin‐8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer , 2008, Cancer science.

[25]  Sharmila Shankar,et al.  Inhibition of PI3K/AKT and MEK/ERK pathways act synergistically to enhance antiangiogenic effects of EGCG through activation of FOXO transcription factor , 2008, Journal of molecular signaling.

[26]  G. Fong.  Mechanisms of adaptive angiogenesis to tissue hypoxia , 2008, Angiogenesis.

[27]  S. Shankar,et al.  Epigallocatechin-3-gallate inhibits cell cycle and induces apoptosis in pancreatic cancer. , 2007, Frontiers in bioscience : a journal and virtual library.

[28]  S. Shankar,et al.  Green tea polyphenols: biology and therapeutic implications in cancer. , 2007, Frontiers in bioscience : a journal and virtual library.

[29]  A. Fukamizu,et al.  FOXO transcription factors in the regulatory networks of longevity. , 2007, Journal of biochemistry.

[30]  M. Simon,et al.  Metastasis and stem cell pathways , 2007, Cancer and Metastasis Reviews.

[31]  P. Steeg.  Tumor metastasis: mechanistic insights and clinical challenges , 2006, Nature Medicine.

[32]  G. Semenza,et al.  Regulation of angiogenesis by hypoxia-inducible factor 1. , 2006, Critical reviews in oncology/hematology.

[33]  Gang Lu,et al.  Possible mechanisms of the cancer-preventive activities of green tea. , 2006, Molecular nutrition & food research.

[34]  K. Al-Kuraya,et al.  Role of phosphatidylinositol 3'-kinase/AKT pathway in diffuse large B-cell lymphoma survival. , 2005, Blood.

[35]  J. Minna,et al.  Promoter characterization of Semaphorin SEMA3F, a tumor suppressor gene. , 2005, Biochimica et biophysica acta.

[36]  W. Fisher,et al.  Pancreatic carcinoma cells express neuropilins and vascular endothelial growth factor, but not vascular endothelial growth factor receptors , 2004, Cancer.

[37]  M. Katoh,et al.  Human FOX gene family (Review). , 2004, International journal of oncology.

[38]  Marten P Smidt,et al.  The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation. , 2004, The Biochemical journal.

[39]  Y. Surh,et al.  Chemopreventive potential of epigallocatechin gallate and genistein: evidence from epidemiological and laboratory studies. , 2004, Toxicology letters.

[40]  L. Beckett,et al.  Incidence, mechanism and prognostic value of activated AKT in pancreas cancer , 2003, British Journal of Cancer.

[41]  Chung S. Yang,et al.  Mechanisms of cancer prevention by tea constituents. , 2003, The Journal of nutrition.

[42]  J. Folkman.  Angiogenesis and proteins of the hemostatic system , 2003, Journal of thrombosis and haemostasis : JTH.

[43]  P. Ratcliffe,et al.  Regulation of angiogenesis by hypoxia: role of the HIF system , 2003, Nature Medicine.

[44]  Insu P. Lee,et al.  A major constituent of green tea, EGCG, inhibits the growth of a human cervical cancer cell line, CaSki cells, through apoptosis, G(1) arrest, and regulation of gene expression. , 2003, DNA and cell biology.

[45]  Scott E Kern,et al.  Focus on pancreas cancer. , 2002, Cancer cell.

[46]  J. Neoptolemos,et al.  Surgical and medical therapy for pancreatic carcinoma. , 2002, Best practice & research. Clinical gastroenterology.

[47]  D. Dowbenko,et al.  The Forkhead Transcription Factor AFX Activates Apoptosis by Induction of the BCL-6 Transcriptional Repressor* , 2002, The Journal of Biological Chemistry.

[48]  J. Lammers,et al.  FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal , 2002, The Journal of cell biology.

[49]  Donghui Li,et al.  Molecular epidemiology of pancreatic cancer , 2001, International journal of gastrointestinal cancer.

[50]  H. Friess,et al.  Effects and expression of TRAIL and its apoptosis-promoting receptors in human pancreatic cancer. , 2001, Cancer letters.

[51]  M. Loda,et al.  Forkhead Transcription Factors Are Critical Effectors of Cell Death and Cell Cycle Arrest Downstream of PTEN , 2000, Molecular and Cellular Biology.

[52]  L. Guarente,et al.  Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase , 2000, Nature.

[53]  M. Greenberg,et al.  Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor , 1999, Cell.

[54]  Jessica Lo,et al.  HIF‐1α is required for solid tumor formation and embryonic vascularization , 1998 .

[55]  W. Cavenee,et al.  Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. , 1998, Genomics.

[56]  G. Semenza,et al.  Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension. , 1996, The American journal of physiology.

[57]  G. Semenza,et al.  Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1 , 1996, Molecular and cellular biology.

[58]  E. Gold,et al.  Epidemiology of and risk factors for pancreatic cancer. , 1995, The Surgical clinics of North America.

[59]  G. Semenza,et al.  Purification and Characterization of Hypoxia-inducible Factor 1 (*) , 1995, The Journal of Biological Chemistry.

[60]  Raimo Väyrynen,et al.  Focus On , 1985, Gastrointestinal Endoscopy.

[61]  Di Chen,et al.  EGCG, green tea polyphenols and their synthetic analogs and prodrugs for human cancer prevention and treatment. , 2011, Advances in clinical chemistry.

[62]  Zhiwei Wang,et al.  Pancreatic cancer: understanding and overcoming chemoresistance , 2011, Nature Reviews Gastroenterology &Hepatology.

[63]  S. Hingorani,et al.  EGCG inhibits growth, invasion, angiogenesis and metastasis of pancreatic cancer. , 2008, Frontiers in bioscience : a journal and virtual library.

[64]  A. Gescher,et al.  Innovative agents in cancer prevention. , 2005, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

[65]  F. Kadlubar,et al.  Chemopreventive effects of tea extracts and various components on human pancreatic and prostate tumor cells in vitro. , 1999, Nutrition and cancer.

[66]  H. Ryan,et al.  HIF-1 alpha is required for solid tumor formation and embryonic vascularization. , 1998, The EMBO journal.