Functional imaging in penile cancer: PET/computed tomography, MRI, and sentinel lymph node biopsy

Purpose of review The presence and extent of lymph node metastasis and primary tumor are among the most important prognostic factors in penile cancer. While inguinal lymphadenectomy is currently the most accurate means of staging, it is associated with severe morbidity and even mortality. Recent literature was reviewed for alternative means of staging. Recent findings Functional imaging modalities distinguish between inguinal lymph nodes with and without metastasis. The false-negative rate of dynamic sentinel lymph node biopsy has recently improved from approximately 20 to 5% in one study. In 13 patients with penile cancer, 18F-fluorodeoxyglucose-PET/computed tomography was 80% sensitive and 100% specific for lymph node metastasis, but missed micro-metastasis. In seven patients with penile cancer, MRI with lymphotrophic nanoparticles was 100% sensitive and 97% specific for lymph node metastasis. Summary Combined PET/computed tomography and sentinel lymph node biopsy may help to detect both inguinal micrometastasis and pelvic and abdominal metastasis. Since MRI is highly accurate for staging of both primary penile cancer and its lymph node metastasis, however, it may turn out to be a powerful tool for a one-stop modality in the staging of penile cancer.

[1]  S. Horenblas,et al.  Reliability and safety of current dynamic sentinel node biopsy for penile carcinoma. , 2007, European urology.

[2]  A. Freeman,et al.  The role of magnetic resonance imaging in the local staging of penile cancer. , 2007, European urology.

[3]  C. Stief,et al.  Risk stratification in penile carcinoma: 25-year experience with surgical inguinal lymph node staging. , 2006, Urology.

[4]  S. Horenblas,et al.  Re: Regional lymph node staging using lymphotropic nanoparticle enhanced magnetic resonance imaging with ferumoxtran-10 in patients with penile cancer. , 2006, The Journal of urology.

[5]  H. G. van der Poel,et al.  Dynamic sentinel node biopsy in penile carcinoma: evaluation of 10 years experience. , 2006, European urology.

[6]  M. Harisinghani,et al.  Imaging of penile neoplasms. , 2005, Radiographics : a review publication of the Radiological Society of North America, Inc.

[7]  M. Harisinghani,et al.  Regional lymph node staging using lymphotropic nanoparticle enhanced magnetic resonance imaging with ferumoxtran-10 in patients with penile cancer. , 2005, The Journal of urology.

[8]  M. Reiser,et al.  18F-FDG PET/CT for staging of penile cancer. , 2005, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[9]  H. Borchers,et al.  [Lymphadenectomy for penile cancer. Diagnostic and prognostic significance as well as therapeutic benefit]. , 2005, Der Urologe. Ausg. A.

[10]  M. Forsting,et al.  Wertigkeit der Bildgebung für die Lymphknotenmetastasierung beim Nierenzell-, Blasen-, Prostata- und Peniskarzinom sowie dem Hodentumor , 2005, Der Urologe, Ausgabe A.

[11]  G. Jakse,et al.  Lymphadenektomie beim Peniskarzinom , 2005, Der Urologe, Ausgabe A.

[12]  C. Pettaway,et al.  Sentinel lymph node biopsy in penile cancer: evolution and insights. , 2005, The Canadian journal of urology.

[13]  B. Konety,et al.  Squamous cell carcinoma of the penis , 2004, Cancer.

[14]  A. Chaturvedi,et al.  Penile carcinoma: a challenge for the developing world. , 2004, The Lancet. Oncology.

[15]  H. Schmid,et al.  Major tumor regression after paclitaxel and carboplatin polychemotherapy in a patient with advanced penile cancer. , 2004, Urology.

[16]  Miao-Fen Chen,et al.  Contemporary management of penile cancer including surgery and adjuvant radiotherapy: an experience in Taiwan , 2004, World Journal of Urology.

[17]  R. Schwartz,et al.  Invasive Penile Carcinoma: A Review , 2004, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[18]  M. Gallee,et al.  A comparison of physical examination and imaging in determining the extent of primary penile carcinoma , 2003, BJU international.

[19]  F. Algaba,et al.  EAU guidelines on penile cancer. , 2002, European urology.

[20]  W. Meinhardt,et al.  Dynamic sentinel node biopsy for penile cancer: reliability of a staging technique. , 2002, The Journal of urology.

[21]  S. Horenblas.  Lymphadenectomy for squamous cell carcinoma of the penis. Part 2: The role and technique of lymph node dissection , 2001, BJU international.

[22]  H. Herzog,et al.  Uptake of cis-4-[18F]fluoro-L-proline in urologic tumors. , 2001, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[23]  G. Ravizzini,et al.  Positron emission tomography detection of metastatic penile squamous cell carcinoma. , 2001, The Journal of urology.

[24]  G. Machin,et al.  The Highly Protective Effect of Newborn Circumcision Against Invasive Penile Cancer , 2000, Pediatrics.

[25]  U. Engelmann,et al.  Results and 10-Year Follow-Up in Patients with Squamous Cell Carcinoma of the Penis , 1999, Urologia Internationalis.

[26]  R. Ravi.  Morbidity following groin dissection for penile carcinoma. , 1993, British journal of urology.

[27]  R. Ravi.  Correlation between the extent of nodal involvement and survival following groin dissection for carcinoma of the penis. , 1993, British journal of urology.

[28]  J. Pow-Sang,et al.  Cancer of the penis. , 2002, Cancer control : journal of the Moffitt Cancer Center.

[29]  M. Forsting,et al.  [Value of imaging for lymph node metastases from renal cell, bladder, prostate, penile, and testicular cancers]. , 2005, Der Urologe. Ausg. A.

[30]  F. Algaba,et al.  European Association of Urology GUIDELINES ON PENILE CANCER , 2001 .