Variable Expression of Long QT Syndrome Among Gene Carriers from Families with Five Different HERG Mutations

Objectives: This study assessed the phenotypic variability of LQTS in carriers with the same and with different mutations in the LQT2 gene.

[1]  R. Elston,et al.  Electrocardiographic Prediction of Abnormal Genotype in Congenital Long QT Syndrome: Experience in 101 Related Family Members , 2001, Journal of cardiovascular electrophysiology.

[2]  A. Moss,et al.  Long QT Syndrome: More Questions , 2001, Journal of cardiovascular electrophysiology.

[3]  G. Breithardt,et al.  Life-threatening Arrhythmias Genotype-phenotype Correlation in the Long-qt Syndrome : Gene-specific Triggers for Genotype-phenotype Correlation in the Long-qt Syndrome Gene-specific Triggers for Life-threatening Arrhythmias , 2022 .

[4]  P. C. Viswanathan,et al.  Novel characteristics of a misprocessed mutant HERG channel linked to hereditary long QT syndrome. , 2000, American journal of physiology. Heart and circulatory physiology.

[5]  A J Moss,et al.  Spectrum of Mutations in Long-QT Syndrome Genes: KVLQT1, HERG, SCN5A, KCNE1, and KCNE2 , 2000, Circulation.

[6]  S. Priori,et al.  Clinical and genetic variables associated with acute arousal and nonarousal-related cardiac events among subjects with long QT syndrome. , 2000, The American journal of cardiology.

[7]  M. Keating,et al.  MiRP1 Forms IKr Potassium Channels with HERG and Is Associated with Cardiac Arrhythmia , 1999, Cell.

[8]  S. Priori,et al.  Low penetrance in the long-QT syndrome: clinical impact. , 1999, Circulation.

[9]  W. Allan,et al.  Long QT Syndrome , 1998, Pediatrics.

[10]  S. Priori,et al.  Influence of the genotype on the clinical course of the long-QT syndrome. International Long-QT Syndrome Registry Research Group. , 1998, The New England journal of medicine.

[11]  C. January,et al.  HERG Channel Dysfunction in Human Long QT Syndrome , 1998, The Journal of Biological Chemistry.

[12]  M. Sanguinetti,et al.  Mutations in the hminK gene cause long QT syndrome and suppress lKs function , 1997, Nature Genetics.

[13]  G. Ginsburg,et al.  Novel missense mutation in the cyclic nucleotide-binding domain of HERG causes long QT syndrome. , 1996, American journal of medical genetics.

[14]  G. Landes,et al.  Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias , 1996, Nature Genetics.

[15]  A. Moss,et al.  ECG T-wave patterns in genetically distinct forms of the hereditary long QT syndrome. , 1995, Circulation.

[16]  Arthur J Moss,et al.  SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome , 1995, Cell.

[17]  E. Green,et al.  A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome , 1995, Cell.

[18]  M. Leppert,et al.  The spectrum of symptoms and QT intervals in carriers of the gene for the long-QT syndrome. , 1992, The New England journal of medicine.

[19]  A. Moss,et al.  The long-QT syndrome Genetic considerations. , 1992, Trends in cardiovascular medicine.

[20]  A. Moss,et al.  The Long QT Syndrome: Prospective Longitudinal Study of 328 Families , 1991, Circulation.

[21]  A. Malliani,et al.  The long Q-T syndrome. , 1975, American heart journal.

[22]  Ward Oc.  A NEW FAMILIAL CARDIAC SYNDROME IN CHILDREN. , 1964 .

[23]  O. C. Ward.  A NEW FAMILIAL CARDIAC SYNDROME IN CHILDREN. , 1964, Journal of the Irish Medical Association.

[24]  E. Kaplan,et al.  Nonparametric Estimation from Incomplete Observations , 1958 .