The transient syndrome of headache with neurologic deficits and CSF lymphocytosis

We describe seven patients who experienced a transient syndrome consisting of headache with neurologic deficits and CSF lymphocytic pleocytosis.Thirty-three similar patients have been reported previously. All had from one to more than 20 episodes of a severe migrainous headache accompanied by a temporary neurologic deficit and lymphocytes in the CSF. Some patients had a preceding viral syndrome, increased intracranial pressure, elevated CSF protein, or focal EEG abnormalities. All stopped having episodes within 3 months. We present diagnostic criteria for this benign syndrome. Its cause remains unknown. NEUROLOGY 1995;45: 1648-1654

[1]  W. Hauser,et al.  Pleocytosis after status epilepticus. , 1994, Archives of neurology.

[2]  B. Ehrenberg,et al.  Migraine‐related seizures in adults with epilepsy, with EEG correlation , 1993, Neurology.

[3]  G. Rice,et al.  Mollaret's meningitis associated with herpes simplex type 2 infection , 1993, Neurology.

[4]  R. Penn,et al.  Neurosurgical horizons in Parkinson's disease , 1993, Neurology.

[5]  L. Robbins,et al.  MRI in Migraineurs , 1992, Headache.

[6]  R. Fishman.  Cerebrospinal Fluid in Diseases of the Nervous System , 1992 .

[7]  F. Fazekas,et al.  The Prevalence of Cerebral Damage Varies With Migraine Type: A MRI Study , 1992, Headache.

[8]  S. Batnitzky,et al.  Magnetic Resonance Image Abnormality in Migraine with Aura , 1991, Cephalalgia : an international journal of headache.

[9]  Jean Côté,et al.  Lyme Disease , 1991, International journal of dermatology.

[10]  C. S. Mitchell,et al.  MR imaging of the brain in patients with migraine headaches. , 1991, AJNR. American journal of neuroradiology.

[11]  Y. Tazaki,et al.  Magnetic Resonance Imaging of The Brain in Patients With Migraine , 1991, Cephalalgia : an international journal of headache.

[12]  E. Tozman,et al.  Sarcoidosis: clinical manifestations, epidemiology, therapy, and pathophysiology , 1991, Current opinion in rheumatology.

[13]  L. Trümper,et al.  [Menetrier's disease: brain infarction as an unusual first symptom]. , 1990, Swiss medical weekly.

[14]  B. Shaywitz,et al.  Migraine associated with focal cerebral edema, cerebrospinal fluid pleocytosis, and progressive cerebellar ataxia , 1990, Neurology.

[15]  L. Thal,et al.  The Lewy body variant of Alzheimer's disease , 1990, Neurology.

[16]  F. Tulunay.  Headache Incidence in 10–16 Years Old School Children in Turkey , 1989 .

[17]  C. Poser.  Headache (2nd Ed.) , 1988, Neurology.

[18]  O. Devinsky,et al.  Cerebrospinal fluid pleocytosis following simple, complex partial, and generalized tonic‐clonic seizures , 1988, Annals of neurology.

[19]  T. Miller.  Mechanisms of stress-related mucosal damage. , 1987, The American journal of medicine.

[20]  H. Hollander,et al.  Human immunodeficiency virus-associated meningitis. Clinical course and correlations. , 1987, The American journal of medicine.

[21]  E. Stamboulis,et al.  Aseptic Inflammatory Meningeal Reaction Manifesting as a Migrainous Syndrome , 1987, Headache.

[22]  N. Browse.  Lymphoedema of the arm. , 1987, British medical journal.

[23]  S. Potolicchio,et al.  Cytomegalovirus encephalitis associated with episodic neurologic deficits and OKT‐8+ pleocytosis , 1987, Neurology.

[24]  R. Fishman.  A tribute to Lewis P. Rowland , 1987, Neurology.

[25]  C. Walter,et al.  Migraine with tardy pleocytosis , 1986, Neurology.

[26]  R. Garruto,et al.  Amyotrophic lateral sclerosis and parkinsonism‐dementia on Guam , 1986, Neurology.

[27]  O. Meienberg,et al.  Basilar Artery Migraine: a Follow‐up Study of 82 Cases , 1985, Headache.

[28]  R. Fitzsimons,et al.  Migraine coma. Meningitic migraine with cerebral oedema associated with a new form of autosomal dominant cerebellar ataxia. , 1985, Brain : a journal of neurology.

[29]  J. Olesen,et al.  Timolol vs. propranolol vs. placebo in common migraine prophylaxis: a double-blind multicenter trial Acta neurol. scand., 69 (1984) 1–8 , 1985, Pain.

[30]  M. Mumenthaler,et al.  BENIGN MIGRAINE‐LIKE SYNDROME WITH CSF PLEOCYTOSIS IN CHILDREN , 1985, Developmental medicine and child neurology.

[31]  W. Knezevic,et al.  Cerebrospinal-fluid abnormalities associated with migraine. , 1984, The Medical journal of Australia.

[32]  B. Hindfelt,et al.  Transient neurological symptoms associated with mononuclear pleocytosis of the cerebrospinal fluid , 1984, Acta neurologica Scandinavica.

[33]  C. I. Johnston.  Blood pressure in children , 1984, Medical Journal of Australia.

[34]  J. Bartleson.  Transient and persistent neurological manifestations of migraine. , 1984, Stroke.

[35]  J. Olesen,et al.  Timolol vs propranolol vs placebo in common migraine prophylaxis: a double‐blind multicenter trial , 1984 .

[36]  B. Dijkmans,et al.  A Migrainous Syndrome with Pleocytosis , 1983, Neurology.

[37]  J. Cramer,et al.  Principles in designing clinical trials for antiepileptic drugs , 1983, Neurology.

[38]  F. Torres,et al.  Hemiplegic migraine in childhood: diagnostic and therapeutic aspects. , 1982, The Journal of pediatrics.

[39]  J. Whisnant,et al.  Membership in ASIM encouraged , 1982, Neurology.

[40]  K. S. Ferguson,et al.  Life-threatening migraine. , 1982, Archives of neurology.

[41]  S. Gilman.  D. Denny‐Brown 1901–1981 , 1982, Neurology.

[42]  J. Whisnant,et al.  A migrainous syndrome with cerebrospinal fluid pleocytosis , 1981, Neurology.

[43]  E. Smeets,et al.  BASILAR MIGRAINE AND VIRAL MENINGITIS , 1981, The Lancet.

[44]  I. Kopin,et al.  Pharmacologic distinction of different orthostatic hypotension syndromes , 1981, Neurology.

[45]  P. Schraeder,et al.  Hemiplegic migraine associated with an aseptic meningeal reaction. , 1980, Archives of neurology.

[46]  J. W. Lance,et al.  Migraine Stupor , 1977, Headache.

[47]  E. Lieberman.  Essential hypertension in children and youth: a pediatric perspective. , 1974, The Journal of pediatrics.

[48]  E. Dooling,et al.  Migrainous hemiplegia during breast-feeding. , 1974, American journal of obstetrics and gynecology.

[49]  P. Cheah,et al.  Mortality in Systemic Lupus Erythematosus: A 10-Year Review , 1973, British medical journal.

[50]  K. McNicol,et al.  Spectrum of Asthma in Children—I, Clinical and Physiological Components , 1973, British medical journal.

[51]  J. Steele,et al.  Alternating hemiplegia in childhood: a report of eight patients with complicated migraine beginning in infancy. , 1971, Pediatrics.

[52]  M. Barrie,et al.  A pharmacological investigation of cerebro-spinal fluid from patients with migraine. , 1967, Brain : a journal of neurology.

[53]  G. Bruyn,et al.  Mollaret's meningitis , 1962, Neurology.

[54]  E. Bickerstaff.  Impairment of consciousness in migraine. , 1961, Lancet.

[55]  F. Tamanini,et al.  Familial hemiplegic migraine. , 1955, The Lancet.

[56]  H. Merritt,et al.  THE CEREBROSPINAL FLUID DURING AND BETWEEN ATTACKS OF MIGRAINE HEADACHES , 1935 .

[57]  A. Adenis,et al.  Thromboembolism as the first symptom of Menetrier's disease. , 1992, American Journal of Gastroenterology.

[58]  P. Myers,et al.  [Cerebral ischemic accidents and tuberculous meningitis]. , 1992, Revue neurologique (Paris).

[59]  J. Anderson,et al.  Benefits and risks of an intensive very-low-calorie diet program for severe obesity. , 1992, The American journal of gastroenterology.

[60]  F. Jiménez-Jiménez,et al.  Neurobrucellosis mimicking migraine. , 1991, European neurology.

[61]  A. López de Munain,et al.  [Luetic meningitis: an atypical form of presentation simulating a pseudomigraine with inflammatory CSF]. , 1990, Revista clínica española (Ed. impresa).

[62]  B. Dobkin.  Migraine and meningitis. , 1981, Archives of neurology.

[63]  W. E. Wellman,et al.  Mollaret's meningitis and differential diagnosis of recurrent meningitis. Report of case, with review of the literature. , 1972, The American journal of medicine.

[64]  H. Mcdevitt,et al.  Histocompatibility antigens, immune responsiveness and susceptibility to disease , 1972 .

[65]  P. Bradshaw,et al.  HEMIPLEGIC MIGRAINE, A CLINICAL STUDY. , 1965, The Quarterly journal of medicine.

[66]  N. Kanof,et al.  A clinical evaluation of Ro 4-2130 in the treatment of pyodermas. , 1962, Antibiotics & chemotherapy.

[67]  C. S. Anglin.  Aseptic meningitis. , 1958, Pediatric clinics of North America.