Absorption of hemoglobin iron.

CONRAD, MARCEL E., LEWIS R. WEINTRAUB, DAVID A. SEARS, AND WILLIAM H. CROSBY. Absorption of hemoglobin iron. Am. J. Physiol. 2 I I (5) : I I 23-1 I 30. rg66.-Hemoglobin-iron was absorbed by the guinea pig as an iron-containing porphyrin compound. Absorption of both inorganic and hemoglobin-iron occurred primarily in the duodenum but about onethird of the quantity absorbed from the gut can be absorbed from the colon and small quantities can be absorbed from other portions of the gut. In the duodenal lumen, hemoglobin was split by proteolytic enzymes into absorbable heme and small quantities of iron. This heme entered the intestinal mucosal cells and subsequently was found in the plasma. Much of the absorbed heme was sequestered by the liver where it was probably degraded and the iron released. Liberated iron was concentrated in the intestinal mucosa where it might act to regulate the absorption of iron but not heme. This could explain the relatively unselective absorption of hemoglobiniron by this animal.

[1]  W. Crosby,et al.  THE ROLE OF THE INTESTINE IN IRON KINETICS. , 1964, The Journal of clinical investigation.

[2]  C. Finch,et al.  Iron absorption. IV. The absorption of hemoglobin iron. , 1962, The Journal of clinical investigation.

[3]  W. Crosby,et al.  Measurement of Total Body Iron59 in Animals Using Whole-Body Liquid Scintillation Detectors , 1962, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[4]  I. Pannacciulli,et al.  Absorption of Inorganic Iron from Graded Doses: Its Significance in Relation to Iron Absorption Tests and the ‘Mucosal Block’ Theory , 1958, British journal of haematology.

[5]  E. Brown,et al.  In vitro absorption of radioiron by everted pouches of rat intestine. , 1958, The American journal of physiology.

[6]  R. Labbé,et al.  A new method of hemin isolation. , 1957, Biochimica et biophysica acta.

[7]  W. Crosby,et al.  A modification of the benzidine method for measurement of hemoglobin in plasma and urine. , 1956, Blood.

[8]  R. J. Walsh,et al.  The availability of iron in meat: some experiments with radioactive iron. , 1955, Australasian annals of medicine.

[9]  W. Clark,et al.  METALLOPORPHYRINS VI. CYCLES OF CHANGES IN SYSTEMS CONTAINING HEME , 1947 .

[10]  C. Moore,et al.  STUDIES IN IRON TRANSPORTATION AND METABOLISM. I. CHEMICAL METHODS AND NORMAL VALUES FOR PLASMA IRON AND "EASILY SPLIT-OFF" BLOOD IRON. , 1937, The Journal of clinical investigation.

[11]  L. Hallberg,et al.  Absorption of hemoglobin iron in man. , 1967, Acta medica Scandinavica.

[12]  M. Nyman.  On plasma proteins with heme or hemoglobin binding capacity. , 1960, Le Scalpel.