Kinase Suppressor of Ras Is Ceramide-Activated Protein Kinase

[1]  Y. Hannun Functions of Ceramide in Coordinating Cellular Responses to Stress , 1996, Science.

[2]  G. Rubin,et al.  KSR modulates signal propagation within the MAPK cascade. , 1996, Genes & development.

[3]  J. Schneider-Mergener,et al.  FAN, a Novel WD-Repeat Protein, Couples the p55 TNF-Receptor to Neutral Sphingomyelinase , 1996, Cell.

[4]  J. Pfeilschifter,et al.  Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[5]  D. Adam,et al.  A Novel Cytoplasmic Domain of the p55 Tumor Necrosis Factor Receptor Initiates the Neutral Sphingomyelinase Pathway* , 1996, The Journal of Biological Chemistry.

[6]  S. Spiegel,et al.  Signal transduction through lipid second messengers. , 1996, Current opinion in cell biology.

[7]  Min Han,et al.  The C. elegans ksr-1 gene encodes a novel raf-related kinase involved in Ras-mediated signal transduction , 1995, Cell.

[8]  H. Horvitz,et al.  The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans , 1995, Cell.

[9]  J. Downward KSR: A novel player in the RAS pathway , 1995, Cell.

[10]  R. Kolesnick,et al.  Phosphorylation of Raf by ceramide-activated protein kinase , 1995, Nature.

[11]  Richard G. W. Anderson,et al.  Compartmentalized Production of Ceramide at the Cell Surface (*) , 1995, The Journal of Biological Chemistry.

[12]  P. Crespo,et al.  The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway , 1995, Cell.

[13]  D. Fabbro,et al.  PKC zeta is a molecular switch in signal transduction of TNF‐alpha, bifunctionally regulated by ceramide and arachidonic acid. , 1995, The EMBO journal.

[14]  C. Belka,et al.  Tumor necrosis factor (TNF)‐alpha activates c‐raf‐1 kinase via the p55 TNF receptor engaging neutral sphingomyelinase. , 1995, The EMBO journal.

[15]  G L Johnson,et al.  Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. , 1994, Science.

[16]  M. Krönke,et al.  Functional dichotomy of neutral and acidic sphingomyelinases in tumor necrosis factor signaling , 1994, Cell.

[17]  L. Sanz,et al.  Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase. , 1994, The Journal of biological chemistry.

[18]  Sally J. Leevers,et al.  Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane , 1994, Nature.

[19]  R. Kolesnick,et al.  Renaturation and tumor necrosis factor-alpha stimulation of a 97-kDa ceramide-activated protein kinase. , 1994, The Journal of biological chemistry.

[20]  R. Kolesnick,et al.  Substrate recognition by ceramide-activated protein kinase. Evidence that kinase activity is proline-directed. , 1993, The Journal of biological chemistry.

[21]  D. Morrison,et al.  Identification of the major phosphorylation sites of the Raf-1 kinase. , 1993, The Journal of biological chemistry.

[22]  S. Elledge,et al.  Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1 , 1993, Nature.

[23]  R. Stephens,et al.  95-kilodalton B-Raf serine/threonine kinase: identification of the protein and its major autophosphorylation site , 1992, Molecular and cellular biology.

[24]  R. Dobrowsky,et al.  Ceramide stimulates a cytosolic protein phosphatase. , 1992, The Journal of biological chemistry.

[25]  R. Kolesnick,et al.  Characterization of a ceramide-activated protein kinase: stimulation by tumor necrosis factor alpha. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[26]  Rapp Ur Role of Raf-1 serine/threonine protein kinase in growth factor signal transduction. , 1991 .

[27]  J. Cleveland,et al.  Expression of raf family proto-oncogenes in normal mouse tissues. , 1990, Oncogene.

[28]  S. Ho,et al.  Site-directed mutagenesis by overlap extension using the polymerase chain reaction. , 1989, Gene.

[29]  T. Hunter,et al.  The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. , 1988, Science.

[30]  L. Old,et al.  Tumor necrosis factor (TNF). , 1985, Science.

[31]  S. Grant,et al.  Ceramide and the induction of apoptosis. , 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

[32]  K. Kaibuchi,et al.  Small GTP-binding proteins. , 1992, International review of cytology.

[33]  R. Kolesnick Sphingomyelin and derivatives as cellular signals. , 1991, Progress in lipid research.

[34]  K. Walsh The Protein Kinase Family , 1987 .