Enhanced relative biological effectiveness of proton radiotherapy in tumor cells with internalized gold nanoparticles.

The development and use of sensitizing agents to improve the effectiveness of radiotherapy have long been sought to improve our ability to treat cancer. In this letter, we have studied the relative biological effectiveness of proton beam radiotherapy on prostate tumor cells with and without internalized gold nanoparticles. The effectiveness of proton radiotherapy for the killing of prostate tumor cells was increased by approximately 15%-20% for those cells containing internalized gold nanoparticles.

[1]  J. Haveman,et al.  Clonogenic assay of cells in vitro , 2006, Nature Protocols.

[2]  Wadih Arap,et al.  Networks of gold nanoparticles and bacteriophage as biological sensors and cell-targeting agents , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[3]  Sang Hyun Cho,et al.  Estimation of microscopic dose enhancement factor around gold nanoparticles by Monte Carlo calculations. , 2010, Medical physics.

[4]  Harald Paganetti,et al.  Relative biological effectiveness (RBE) values for proton beam therapy. , 2002, International journal of radiation oncology, biology, physics.

[5]  Michael Hsiao,et al.  Enhancement of cell radiation sensitivity by pegylated gold nanoparticles , 2010, Physics in medicine and biology.

[6]  J. Hainfeld,et al.  The use of gold nanoparticles to enhance radiotherapy in mice. , 2004, Physics in medicine and biology.

[7]  Frank Verhaegen,et al.  Dosimetric and microdosimetric study of contrast-enhanced radiotherapy with kilovolt x-rays , 2005, Physics in medicine and biology.

[8]  Seung-Jun Seo,et al.  Therapeutic application of metallic nanoparticles combined with particle-induced x-ray emission effect , 2010, Nanotechnology.

[9]  M. Ozawa,et al.  An unrecognized extracellular function for an intracellular adapter protein released from the cytoplasm into the tumor microenvironment , 2009, Proceedings of the National Academy of Sciences.

[10]  E. Hall,et al.  Radiobiology for the radiologist , 1973 .

[11]  Sang Hyun Cho,et al.  Estimation of tumour dose enhancement due to gold nanoparticles during typical radiation treatments: a preliminary Monte Carlo study , 2005, Physics in medicine and biology.