Estimation of the incubation period of invasive aspergillosis by survival models in acute myeloid leukemia patients.

The duration of the incubation of invasive aspergillosis (IA) remains unknown. The objective of this investigation was to estimate the time interval between aplasia onset and that of IA symptoms in acute myeloid leukemia (AML) patients. A single-centre prospective survey (2004-2009) included all patients with AML and probable/proven IA. Parametric survival models were fitted to the distribution of the time intervals between aplasia onset and IA. Overall, 53 patients had IA after aplasia, with the median observed time interval between the two being 15 days. Based on log-normal distribution, the median estimated IA incubation period was 14.6 days (95% CI; 12.8-16.5 days).

[1]  B. Strom,et al.  Prolonged granulocytopenia: the major risk factor for invasive pulmonary aspergillosis in patients with acute leukemia. , 1984, Annals of internal medicine.

[2]  P. Vanhems,et al.  Reduction of invasive aspergillosis incidence among immunocompromised patients after control of environmental exposure. , 2007, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[3]  N. Voirin,et al.  The Incubation Period of Acute Retroviral Syndrome as a Multistep Process: A Parametric Survival Analysis , 2004, Journal of acquired immune deficiency syndromes.

[4]  Hiroshi Nishiura,et al.  Early efforts in modeling the incubation period of infectious diseases with an acute course of illness , 2007, Emerging themes in epidemiology.

[5]  A M Lilienfeld,et al.  Incubation period of disease. , 1983, Epidemiologic reviews.

[6]  Antoine Duclos,et al.  Invasive aspergillosis in patients with hematologic malignancies: incidence and description of 127 cases enrolled in a single institution prospective survey from 2004 to 2009 , 2011, Haematologica.

[7]  A. Niimi,et al.  Murine model of invasive pulmonary aspergillosis following an earlier stage, noninvasive Aspergillus infection , 1996, Journal of clinical microbiology.

[8]  S. Kusne,et al.  Infection control issues after solid organ transplantation , 2012 .

[9]  D. Kontoyiannis,et al.  Enemy of the (immunosuppressed) state: an update on the pathogenesis of Aspergillus fumigatus infection , 2010, British journal of haematology.

[10]  A. J. Hall.  Infectious diseases of humans: R. M. Anderson & R. M. May. Oxford etc.: Oxford University Press, 1991. viii + 757 pp. Price £50. ISBN 0-19-854599-1 , 1992 .

[11]  P E SARTWELL,et al.  The distribution of incubation periods of infectious disease. , 1950, American journal of hygiene.

[12]  Patricia Muñoz,et al.  Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. , 2008, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[13]  P Philippe,et al.  Sartwell's incubation period model revisited in the light of dynamic modeling. , 1994, Journal of clinical epidemiology.

[14]  N. Sopena,et al.  Multicenter study of hospital-acquired pneumonia in non-ICU patients. , 2005, Chest.

[15]  R. Brookmeyer,et al.  Incubation periods of acute respiratory viral infections: a systematic review , 2009, The Lancet Infectious Diseases.