Base editing generates substantial off-target single nucleotide variants
暂无分享,去创建一个
Lars M. Steinmetz | Hui Yang | L. Steinmetz | Yixue Li | Yidi Sun | Erwei Zuo | Wu Wei | Tanglong Yuan | Wenqin Ying | Hui Yang | Erwei Zuo | Yidi Sun | Wenqin Ying | Yixue Li | Tanglong Yuan | Wu Wei
[1] Steve D. M. Brown,et al. Response to "unexpected mutations after CRISPR-Cas9 editing in vivo" , 2018 .
[2] Steve D. M. Brown,et al. Response to “Unexpected mutations after CRISPR–Cas9 editing in vivo” , 2018, Nature Methods.
[3] J. Drake,et al. Rates of spontaneous mutation. , 1998, Genetics.
[4] Thomas M. Keane,et al. Off-target mutations are rare in Cas9-modified mice , 2015, Nature Methods.
[5] Allan R. Jones,et al. A robust and high-throughput Cre reporting and characterization system for the whole mouse brain , 2009, Nature Neuroscience.
[6] L. Hennighausen,et al. Mutation frequency is not increased in CRISPR–Cas9-edited mice , 2018, Nature Methods.
[7] N. Navaratnam,et al. RNA editing: cytidine to uridine conversion in apolipoprotein B mRNA. , 2000, Biochimica et biophysica acta.
[8] David R. Liu,et al. Publisher Correction: Base editing: precision chemistry on the genome and transcriptome of living cells , 2018, Nature Reviews Genetics.
[9] O. Rando,et al. Nucleosome positioning: how is it established, and why does it matter? , 2010, Developmental biology.
[10] Lothar Hennighausen,et al. CRISPR/Cas9 targeting events cause complex deletions and insertions at 17 sites in the mouse genome , 2017, Nature Communications.
[11] H. Hakonarson,et al. ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data , 2010, Nucleic acids research.
[12] Ewa A. Bergmann,et al. Indel variant analysis of short-read sequencing data with Scalpel , 2015, Nature Protocols.
[13] J. Doudna,et al. Cornerstones of CRISPR–Cas in drug discovery and therapy , 2016, Nature Reviews Drug Discovery.
[14] Martin J. Aryee,et al. GUIDE-Seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases , 2014, Nature Biotechnology.
[15] Tao Liu,et al. Cistrome Data Browser: a data portal for ChIP-Seq and chromatin accessibility data in human and mouse , 2016, Nucleic Acids Res..
[16] Wendy S. W. Wong,et al. Strelka: accurate somatic small-variant calling from sequenced tumor-normal sample pairs , 2012, Bioinform..
[17] Jonathan Y. Hsu,et al. Response to “Unexpected mutations after CRISPR–Cas9 editing in vivo” , 2018, Nature Methods.
[18] Jin-Soo Kim,et al. Towards therapeutic base editing , 2018, Nature Medicine.
[19] J. Joung,et al. Defining and improving the genome-wide specificities of CRISPR–Cas9 nucleases , 2016, Nature Reviews Genetics.
[20] Guoliang Xu,et al. CRISPR-Cas9-mediated genome editing in one blastomere of two-cell embryos reveals a novel Tet3 function in regulating neocortical development , 2017, Cell Research.
[21] Michel Sadelain,et al. Gene therapy comes of age , 2018, Science.
[22] J. Kent,et al. Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR , 2016, Genome Biology.
[23] Jin-Soo Kim,et al. Therapeutic applications of CRISPR RNA-guided genome editing. , 2017, Briefings in functional genomics.
[24] A. Bradley,et al. Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements , 2018, Nature Biotechnology.
[25] David R. Liu,et al. Base editing: precision chemistry on the genome and transcriptome of living cells , 2018, Nature Reviews Genetics.
[26] Jin-Soo Kim,et al. Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases , 2014, Bioinform..
[27] A. Bassuk,et al. Unexpected mutations after CRISPR–Cas9 editing in vivo , 2017, Nature Methods.
[28] A. Sivachenko,et al. Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples , 2013, Nature Biotechnology.
[29] Eva Szomolanyi-Tsuda,et al. The AIM2 inflammasome is essential for host-defense against cytosolic bacteria and DNA viruses , 2010, Nature Immunology.
[30] K. Musunuru. The Hope and Hype of CRISPR-Cas9 Genome Editing: A Review , 2017, JAMA cardiology.
[31] Richard L. Frock,et al. Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases , 2014, Nature Biotechnology.
[32] J. Joung,et al. CIRCLE-seq: a highly sensitive in vitro screen for genome-wide CRISPR-Cas9 nuclease off-targets , 2017, Nature Methods.
[33] C. Burant,et al. Molecular cloning of an apolipoprotein B messenger RNA editing protein. , 1993, Science.
[34] A. Krieg. AIMing 2 defend against intracellular pathogens , 2010, Nature Immunology.
[35] Claudio Mussolino,et al. Refining strategies to translate genome editing to the clinic , 2017, Nature Medicine.
[36] Dana Carroll,et al. Nucleosomes inhibit target cleavage by CRISPR-Cas9 in vivo , 2018, Proceedings of the National Academy of Sciences.
[37] D. Schemske,et al. OUTCROSSING RATE AND INBREEDING DEPRESSION IN TWO ANNUAL MONOECIOUS HERBS, BEGONIA HIRSUTA AND B. SEMIOVATA , 1993, Evolution; international journal of organic evolution.
[38] A. Wilm,et al. LoFreq: a sequence-quality aware, ultra-sensitive variant caller for uncovering cell-population heterogeneity from high-throughput sequencing datasets , 2012, Nucleic acids research.
[39] E. Kudryashova,et al. Deficiency of the E3 ubiquitin ligase TRIM32 in mice leads to a myopathy with a neurogenic component. , 2009, Human molecular genetics.
[40] Hui Yang,et al. One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs , 2017, Cell Research.
[41] Martin J. Aryee,et al. In vivo CRISPR editing with no detectable genome-wide off-target mutations , 2018, Nature.
[42] M. Buck,et al. Chromatin accessibility: a window into the genome , 2014, Epigenetics & Chromatin.