Immunologic studies in haemophilia A.

The defect in haemophilia A may be due to the absence or deficiency of factor VIII or to the formation of a defective factor VIII. With the use of both an inhibitor neutralising test and a heterologous antiserum against factor VIII 44 patients with haemophilia A were studied for factor VIII related antigenic material in plasma. All the patients had a factor VIII related protein, immunochemically demonstrable with rabbit antiserum but only 4 patients with mild haemophilia A, all belonging to the same family, could neutralise a human inhibitor. 4 patients with haemophilia A and a circulating anticoagulant also had antigenic material. In 1 patient without haemophilia but with an anticoagulant against factor VIII the level of the factor VIII related protein was high.

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