1,2,5-Oxadiazole N-oxide derivatives as potential anti-cancer agents: synthesis and biological evaluation. Part IV.

[1]  A. Vogel,et al.  Vogel's Textbook of Practical Organic Chemistry , 2003 .

[2]  Á. Mombrú,et al.  Synthesis and Biological Evaluation of 1,2,5‐Oxadiazole N‐Oxide Derivatives as Potential Hypoxic Cytotoxins and DNA‐Binders , 2000, Archiv der Pharmazie.

[3]  A. López de Cerain,et al.  New quinoxalinecarbonitrile 1,4-di-N-oxide derivatives as hypoxic-cytotoxic agents. , 2000, European journal of medicinal chemistry.

[4]  G. Peluffo,et al.  1,2,5-Oxadiazole N-oxide derivatives and related compounds as potential antitrypanosomal drugs: structure-activity relationships. , 1999, Journal of medicinal chemistry.

[5]  G. Seoane.  1,2,5‐Oxadiazole N‐Oxide Derivatives as Hypoxia‐Selective Cytotoxins: Structure—Activity Relationships. , 1999 .

[6]  A. Rauth,et al.  Bioreductive therapies: an overview of drugs and their mechanisms of action. , 1998, International journal of radiation oncology, biology, physics.

[7]  G. Adams,et al.  Indolequinone antitumor agents: reductive activation and elimination from (5-methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl derivatives and hypoxia-selective cytotoxicity in vitro. , 1998, Journal of medicinal chemistry.

[8]  G. Seoane,et al.  Electron Spin Resonance and Cyclic Voltammetry Studies of Nitrofurane and Nitrothiophene Analogues of Nifurtimox , 1998 .

[9]  G. Seoane,et al.  Cyclic Voltammetry and Electron Paramagnetic Resonance Studies of Some Analogues of Nifurtimox. , 1998 .

[10]  P. Workman,et al.  Bioreductive metabolism of the novel fluorinated 2-nitroimidazole hypoxia probe N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitroimidazolyl) acetamide (SR-4554). , 1997, Biochemical pharmacology.

[11]  W. Denny,et al.  Hypoxia-selective antitumor agents. 15. Modification of rate of nitroreduction and extent of lysosomal uptake by polysubstitution of 4-(alkylamino)-5-nitroquinoline bioreductive drugs. , 1997, Journal of medicinal chemistry.

[12]  C. Cena,et al.  Water soluble furoxan derivatives as NO prodrugs. , 1997, Journal of medicinal chemistry.

[13]  W. Denny,et al.  Hypoxia-selective antitumor agents. 13. Effects of acridine substitution on the hypoxia-selective cytotoxicity and metabolic reduction of the bis-bioreductive agent nitracrine N-oxide. , 1996, Journal of medicinal chemistry.

[14]  A. López de Cerain,et al.  Hypoxia-selective agents derived from 2-quinoxalinecarbonitrile 1,4-di-N-oxides. 2. , 1995, Journal of medicinal chemistry.

[15]  A. Barker,et al.  NEW HYPOXIA-SELECTIVE CYTOTOXINES DERIVED FROM QUINOXALINE 1,4-DIOXIDES , 1995 .

[16]  R. Fruttero,et al.  Furoxans as nitric oxide donors. 4-Phenyl-3-furoxancarbonitrile: thiol-mediated nitric oxide release and biological evaluation. , 1994, Journal of medicinal chemistry.

[17]  W. Denny,et al.  Hypoxia-selective antitumor agents. 9. Structure-activity relationships for hypoxia-selective cytotoxicity among analogues of 5-[N,N-bis(2-chloroethyl)amino]-2,4-dinitrobenzamide. , 1994, Journal of medicinal chemistry.

[18]  W. Denny,et al.  Exploiting tumor hypoxia through bioreductive release of diffusible cytotoxins: the cobalt(III)-nitrogen mustard complex SN 24771. , 1994, International journal of radiation oncology, biology, physics.

[19]  J. Brown,et al.  SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours. , 1993, British Journal of Cancer.

[20]  A. Wolf,et al.  Synthesis of (R)-(-)- and (S)-(+)-4-fluorodeprenyl and (R)-(-)- and (S)-(+)-[N-11C-methyl]-4-fluorodeprenyl and positron emission tomography studies in baboon brain. , 1990, Journal of medicinal chemistry.

[21]  B. Teicher,et al.  Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells. , 1981, Cancer research.

[22]  S H Unger,et al.  "Aromatic" substituent constants for structure-activity correlations. , 1973, Journal of medicinal chemistry.

[23]  S. Rockwell,et al.  Cellular radiosensitivity and tumor radiation response in the EMT6 tumor cell system. , 1973, Radiation research.

[24]  C. A. Bunton,et al.  Deamination of nerylamine and geranylamine , 1972 .

[25]  C. Gardner Swain,et al.  Field and resonance components of substituent effects , 1968 .

[26]  J. H. Boyer,et al.  Deoxygenation of Aromatic o-Dinitroso Derivatives by Phosphines1 , 1961 .

[27]  W. F. Olszewski,et al.  The Reaction of Triphenylphosphine with Some Aromatic Amine Oxides1 , 1959 .

[28]  H. Gutmann,et al.  Synthesen in der Carotinoid-Reihe. 10. Mitteilung. Anwendung der Wittig-Reaktion zur Synthese von Estern des Bixins und Crocetins† , 1957 .

[29]  Georg Wittig,et al.  Über Triphenyl-phosphinmethylene als olefinbildende Reagenzien (II. Mitteil.1)) , 1955 .