Kv1.3 Potassium Channel: Physiology, Pharmacology and Therapeutic Indications

[1]  Christine Beeton,et al.  Potassium Channels, Memory T Cells, and Multiple Sclerosis , 2005, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[2]  P. Calabresi,et al.  The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[3]  Ethan M. Goldberg,et al.  Stichodactyla helianthus Peptide, a Pharmacological Tool for Studying Kv3.2 Channels , 2005, Molecular Pharmacology.

[4]  A. Nomeir,et al.  Blocking ion channel KCNN4 alleviates the symptoms of experimental autoimmune encephalomyelitis in mice , 2005, European journal of immunology.

[5]  F. Lang,et al.  A Novel Potassium Channel in Lymphocyte Mitochondria* , 2005, Journal of Biological Chemistry.

[6]  L. Possani,et al.  Anuroctoxin, a New Scorpion Toxin of the α-KTx 6 Subfamily, Is Highly Selective for Kv1.3 over IKCa1 Ion Channels of Human T Lymphocytes , 2005, Molecular Pharmacology.

[7]  P. Calabresi,et al.  Targeting Effector Memory T Cells with a Selective Peptide Inhibitor of Kv1.3 Channels for Therapy of Autoimmune Diseases , 2005, Molecular Pharmacology.

[8]  F. Barkhof,et al.  Treatment with laquinimod reduces development of active MRI lesions in relapsing MS , 2005, Neurology.

[9]  Jiang Zhu,et al.  Alloreactive Memory T Cells Are Responsible for the Persistence of Graft-versus-Host Disease1 , 2005, The Journal of Immunology.

[10]  C. Kernich Patient and family fact sheet. Current treatments for multiple sclerosis. , 2005, The neurologist.

[11]  P. Gopalakrishnakone,et al.  Assignment of voltage-gated potassium channel blocking activity to κ-ktx1.3, a non-toxic homologue of κ-hefutoxin-1, from Heterometrus spinifer venom , 2005 .

[12]  A. Gottlieb,et al.  Psoriasis treatment: current and emerging directed therapies , 2005, Annals of the rheumatic diseases.

[13]  D. Nelson,et al.  Whole-cell currents in macrophages: I. Human monocyte-derived macrophages , 1990, The Journal of Membrane Biology.

[14]  E. Gallin,et al.  Patch-clamp studies in human macrophages: Single-channel and whole-cell characterization of two K+ conductances , 1988, The Journal of Membrane Biology.

[15]  S. Grissmer,et al.  K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom. , 2005, The Biochemical journal.

[16]  V. Gallo,et al.  Shaker‐type potassium channel subunits differentially control oligodendrocyte progenitor proliferation , 2004, Glia.

[17]  R. Davies,et al.  CD56bright NK Cells Are Enriched at Inflammatory Sites and Can Engage with Monocytes in a Reciprocal Program of Activation1 , 2004, The Journal of Immunology.

[18]  R. V. van Lier,et al.  Differentiation of Human Alloreactive CD4+ and CD8+ T Cells In Vitro , 2004, Transplantation.

[19]  T. Yamamura,et al.  The regulatory role of natural killer cells in multiple sclerosis. , 2004, Brain : a journal of neurology.

[20]  K. Chandy,et al.  K+ Channel Expression during B Cell Differentiation: Implications for Immunomodulation and Autoimmunity1 , 2004, The Journal of Immunology.

[21]  D. Roden Drug-induced prolongation of the QT interval. , 2004, The New England journal of medicine.

[22]  Michael P. Ferber,et al.  Identification of a mammalian target of KM-conotoxin RIIIK , 2004 .

[23]  A. Ménez,et al.  Comparison of sea anemone and scorpion toxins binding to Kv1 channels: an example of convergent evolution. , 2004, Toxicon : official journal of the International Society on Toxinology.

[24]  P. Calabresi,et al.  Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators. , 2004, Molecular pharmacology.

[25]  G. Illei,et al.  Severe chronic graft-versus-host disease is characterized by a preponderance of CD4(+) effector memory cells relative to central memory cells. , 2004, Blood.

[26]  R. Ravid,et al.  Expression of CCR7 in multiple sclerosis: Implications for CNS immunity , 2004, Annals of neurology.

[27]  P. V. D. van de Kerkhof,et al.  Memory effector (CD45RO+) and cytotoxic (CD8+) T cells appear early in the margin zone of spreading psoriatic lesions in contrast to cells expressing natural killer receptors, which appear late , 2004, The British journal of dermatology.

[28]  P. Lipsky,et al.  Correlation of circulating CD27high plasma cells and disease activity in systemic lupus erythematosus , 2004, Lupus.

[29]  F. Lehmann,et al.  Physiological mechanisms of lysophosphatidylcholine‐induced de‐ramification of murine microglia , 2004, The Journal of physiology.

[30]  J. Baell,et al.  Khellinone derivatives as blockers of the voltage-gated potassium channel Kv1.3: synthesis and immunosuppressive activity. , 2004, Journal of medicinal chemistry.

[31]  L. Kaczmarek,et al.  The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[32]  L. Kaczmarek,et al.  Kv1.3 Channel Gene-Targeted Deletion Produces “Super-Smeller Mice” with Altered Glomeruli, Interacting Scaffolding Proteins, and Biophysics , 2004, Neuron.

[33]  Mark Peakman,et al.  Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health. , 2004, The Journal of clinical investigation.

[34]  J. V. Van Beeumen,et al.  A Subfamily of Acidic α-K+ Toxins* , 2004, Journal of Biological Chemistry.

[35]  J. Gudjonsson,et al.  Immunopathogenic mechanisms in psoriasis , 2004, Clinical and experimental immunology.

[36]  T. Kawai,et al.  Selective Blockade of Voltage‐Gated Potassium Channels Reduces Inflammatory Bone Resorption in Experimental Periodontal Disease , 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[37]  K. Chandy,et al.  Molecular Properties and Physiological Roles of Ion Channels in the Immune System , 2001, Journal of Clinical Immunology.

[38]  A. Woods,et al.  Assignment of the three disulfide bonds in ShK toxin: A potent potassium channel inhibitor from the sea anemone Stichodactyla helianthus , 1995, Letters in peptide science.

[39]  D. Nelson,et al.  Lipopolysaccharide induction of outward potassium current expression in human monocyte-derived macrophages: Lack of correlation with secretion , 1992, The Journal of Membrane Biology.

[40]  Sherwin C. Lee,et al.  Forskolin effects on the voltage-gated K+ conductance of human T cells , 1988, Pflügers Archiv.

[41]  K. Tucker,et al.  Comparison of modulation of Kv1.3 channel by two receptor tyrosine kinases in olfactory bulb neurons of rodents. , 2004, Receptors & channels.

[42]  T. Kupper Immunologic targets in psoriasis. , 2003, The New England journal of medicine.

[43]  R. Collins,et al.  Chronic graft-vs-host disease. , 2003, JAMA.

[44]  J. C. Mateos,et al.  Human Adipose Cells Have Voltage-dependent Potassium Currents , 2003, The Journal of Membrane Biology.

[45]  O. McManus,et al.  Substitution of a single residue in Stichodactyla helianthus peptide, ShK-Dap22, reveals a novel pharmacological profile. , 2003, Biochemistry.

[46]  L. Kaczmarek,et al.  Compensatory Anion Currents in Kv1.3 Channel-deficient Thymocytes* , 2003, Journal of Biological Chemistry.

[47]  C. Eder,et al.  Effects of kinase inhibitors on TGF-β induced upregulation of Kv1.3 K+ channels in brain macrophages , 2003, Pflügers Archiv.

[48]  H. Ochs,et al.  Functional analysis of human memory B-cell subpopulations: IgD+CD27+ B cells are crucial in secondary immune response by producing high affinity IgM. , 2003, Clinical immunology.

[49]  H. Ulmer,et al.  Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event. , 2003, The New England journal of medicine.

[50]  R. Moots,et al.  Natural killer cells in the synovial fluid of rheumatoid arthritis patients exhibit a CD56bright,CD94bright,CD158negative phenotype. , 2003, Rheumatology.

[51]  I. Huys,et al.  A novel conotoxin inhibiting vertebrate voltage-sensitive potassium channels. , 2003, Toxicon : official journal of the International Society on Toxinology.

[52]  M. Müller,et al.  The role of membrane-bound LBP, endotoxin aggregates, and the MaxiK channel in LPS-induced cell activation , 2003, Journal of endotoxin research.

[53]  P. Calabresi,et al.  The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS. , 2003, The Journal of clinical investigation.

[54]  Karin Reiter,et al.  Correlation between circulating CD27high plasma cells and disease activity in patients with systemic lupus erythematosus. , 2003, Arthritis and rheumatism.

[55]  Y. S. Tang,et al.  Di-substituted cyclohexyl derivatives bind to two identical sites with positive cooperativity on the voltage-gated potassium channel, K(v)1.3. , 2003, Biochemistry.

[56]  Bart O. Roep,et al.  The role of T-cells in the pathogenesis of Type 1 diabetes: From cause to cure , 2003, Diabetologia.

[57]  James J. Campbell,et al.  CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking. , 2003, Blood.

[58]  T. Waldmann,et al.  Colocalization and nonrandom distribution of Kv1.3 potassium channels and CD3 molecules in the plasma membrane of human T lymphocytes , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[59]  M. Petrović,et al.  Hypoxia Regulates Expression and Activity of Kv1.3 Channels in T Lymphocytes: A Possible Role in T Cell Proliferation1 , 2003, The Journal of Immunology.

[60]  David H. Miller,et al.  A controlled trial of natalizumab for relapsing multiple sclerosis. , 2003, The New England journal of medicine.

[61]  R. Vianna-Jorge,et al.  Shaker‐type Kv1 channel blockers increase the peristaltic activity of guinea‐pig ileum by stimulating acetylcholine and tachykinins release by the enteric nervous system , 2003, British journal of pharmacology.

[62]  D. Serreze,et al.  The role of B lymphocytes as key antigen-presenting cells in the development of T cell-mediated autoimmune type 1 diabetes. , 2002, Current directions in autoimmunity.

[63]  F. Sallusto,et al.  Cytokine-driven proliferation and differentiation of human naïve, central memory and effector memory CD4+ T cells. , 2003, Pathologie-biologie.

[64]  B. Freedman,et al.  Modulation of Kv Channel Expression and Function by TCR and Costimulatory Signals during Peripheral CD4+ Lymphocyte Differentiation , 2002, The Journal of experimental medicine.

[65]  K. Chandy,et al.  Mutating a critical lysine in ShK toxin alters its binding configuration in the pore-vestibule region of the voltage-gated potassium channel, Kv1.3. , 2002, Biochemistry.

[66]  Mansoor Abdul,et al.  Voltage-gated potassium ion channels in colon cancer. , 2002, Oncology reports.

[67]  P. Lipsky,et al.  Diminished peripheral blood memory B cells and accumulation of memory B cells in the salivary glands of patients with Sjögren's syndrome. , 2002, Arthritis and rheumatism.

[68]  Michael Loran Dustin,et al.  The immunological synapse: integrins take the stage , 2002, Immunological reviews.

[69]  O. McManus,et al.  Identification of a new class of inhibitors of the voltage-gated potassium channel, Kv1.3, with immunosuppressant properties. , 2002, Biochemistry.

[70]  Peter A. Calabresi,et al.  Chemokine receptor expression on MBP-reactive T cells: CXCR6 is a marker of IFNγ-producing effector cells , 2002, Journal of Neuroimmunology.

[71]  F. Cayabyab,et al.  Regulation of an ERG K+ Current by Src Tyrosine Kinase* , 2002, The Journal of Biological Chemistry.

[72]  G. Schütz,et al.  Synthesis, characterization, and application of cy-dye- and alexa-dye-labeled hongotoxin(1) analogues. The first high affinity fluorescence probes for voltage-gated K+ channels. , 2002, Bioconjugate chemistry.

[73]  I. Huys,et al.  Purification, characterization and biosynthesis of parabutoxin 3, a component of Parabuthus transvaalicus venom. , 2002, European journal of biochemistry.

[74]  I. Eardley,et al.  Potassium channel KV alpha1 subunit expression and function in human detrusor muscle. , 2002, The Journal of urology.

[75]  Jonathan B. Baell,et al.  Design and synthesis of type-III mimetics of ShK toxin , 2002, J. Comput. Aided Mol. Des..

[76]  K. Whaley,et al.  Decreased Total Numbers of Peripheral Blood Lymphocytes with Elevated Percentages of CD4+CD45RO+ and CD4+CD25+ of T‐Helper Cells in Non‐Segmental Vitiligo , 2002, The Journal of dermatology.

[77]  H. Gendelman,et al.  Mononuclear phagocyte biophysiology influences brain transendothelial and tissue migration: implication for HIV-1-associated dementia , 2002, Journal of Neuroimmunology.

[78]  B. Tomkinson,et al.  Oligoclonal expansion of intraepidermal T cells in psoriasis skin lesions. , 2001, The Journal of investigative dermatology.

[79]  David E. Anderson,et al.  Immunological Memory: Contribution of Memory B Cells Expressing Costimulatory Molecules in the Resting State1 , 2001, The Journal of Immunology.

[80]  H. McFarland,et al.  CD4+CD28- costimulation-independent T cells in multiple sclerosis. , 2001, The Journal of clinical investigation.

[81]  J. Natvig,et al.  Significantly Depressed Percentage of CD27+ (Memory) B Cells among Peripheral Blood B Cells in Patients with Primary Sjögren's Syndrome , 2001, Scandinavian journal of immunology.

[82]  K. Chandy,et al.  Potassium channels in T lymphocytes: toxins to therapeutic immunosuppressants. , 2001, Toxicon : official journal of the International Society on Toxinology.

[83]  H. Lester,et al.  Kir4.1 Potassium Channel Subunit Is Crucial for Oligodendrocyte Development and In Vivo Myelination , 2001, The Journal of Neuroscience.

[84]  M. Atkinson,et al.  Type 1 diabetes: new perspectives on disease pathogenesis and treatment , 2001, The Lancet.

[85]  M. Müller,et al.  A K+ channel is involved in LPS signaling , 2001, Journal of endotoxin research.

[86]  R. Hohlfeld,et al.  Immunological update on multiple sclerosis , 2001, Current opinion in neurology.

[87]  John Noseworthy,et al.  Multiple sclerosis: recent developments in neuropathology, pathogenesis, magnetic resonance imaging studies and treatment , 2001, Current opinion in neurology.

[88]  Mark J. Miller,et al.  Calcium-activated Potassium Channels Sustain Calcium Signaling in T Lymphocytes , 2001, The Journal of Biological Chemistry.

[89]  D. Min,et al.  Inhibition of Kv1.3 channels by H-89 (N--[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide) independent of protein kinase A. , 2001, Biochemical pharmacology.

[90]  Anjana Rao,et al.  Gene regulation mediated by calcium signals in T lymphocytes , 2001, Nature Immunology.

[91]  X. Zhu,et al.  K+ channels and the microglial respiratory burst. , 2001, American journal of physiology. Cell physiology.

[92]  K. Möller,et al.  Angular methoxy-substituted furo- and pyranoquinolinones as blockers of the voltage-gated potassium channel Kv1.3. , 2001, Journal of medicinal chemistry.

[93]  G. Levi,et al.  Altered outward‐rectifying K+ current reveals microglial activation induced by HIV‐1 Tat protein , 2001, Glia.

[94]  M. Péter,et al.  Multiple binding sites for melatonin on Kv1.3. , 2001, Biophysical journal.

[95]  G. Bills,et al.  Candelalides A-C: novel diterpenoid pyrones from fermentations of Sesquicillium candelabrum as blockers of the voltage-gated potassium channel Kv1.3. , 2001, Organic letters.

[96]  P. Giraud,et al.  Selective Blocking of Voltage-Gated K+ Channels Improves Experimental Autoimmune Encephalomyelitis and Inhibits T Cell Activation1 , 2001, The Journal of Immunology.

[97]  T. Kawai,et al.  Involvement of T-lymphocytes in periodontal disease and in direct and indirect induction of bone resorption. , 2001, Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists.

[98]  Richard S Lewis,et al.  Calcium signaling mechanisms in T lymphocytes. , 2001, Annual review of immunology.

[99]  M. Lund,et al.  Telomerase Activity Is Increased and Telomere Length Shortened in T Cells from Blood of Patients with Atopic Dermatitis and Psoriasis1 , 2000, The Journal of Immunology.

[100]  D. D'cruz,et al.  Localized monocyte chemotactic protein-1 production correlates with T cell infiltration of synovium in patients with psoriatic arthritis. , 2000, The Journal of rheumatology.

[101]  R. Vianna-Jorge,et al.  Correolide, a nor‐triterpenoid blocker of Shaker‐type Kv1 channels elicits twitches in guinea‐pig ileum by stimulating the enteric nervous system and enhancing neurotransmitter release , 2000, British journal of pharmacology.

[102]  F. N. Quandt,et al.  Upregulation of Kv1.3 K(+) channels in microglia deactivated by TGF-beta. , 2000, American journal of physiology. Cell physiology.

[103]  K. Asadullah,et al.  Flow cytometric characterization of lesional T cells in psoriasis: intracellular cytokine and surface antigen expression indicates an activated, memory/effector type 1 immunophenotype , 2000, Archives of Dermatological Research.

[104]  A. Evans,et al.  Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial , 2000, Nature Medicine.

[105]  J. Frank,et al.  Encephalitogenic potential of the myelin basic protein peptide (amino acids 83–99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand , 2000, Nature Medicine.

[106]  J. Lorenzo Interactions between immune and bone cells: new insights with many remaining questions. , 2000, The Journal of clinical investigation.

[107]  S. M. Sims,et al.  Electrophysiological characterization of ion channels in osteoclasts isolated from human deciduous teeth. , 2000, Bone.

[108]  O. Pongs,et al.  Generating a High Affinity Scorpion Toxin Receptor in KcsA-Kv1.3 Chimeric Potassium Channels* , 2000, The Journal of Biological Chemistry.

[109]  R. Khanna,et al.  Suppression of the rat microglia Kv1.3 current by src‐family tyrosine kinases and oxygen/glucose deprivation , 2000, The European journal of neuroscience.

[110]  H. Hartung,et al.  The role of B cells and autoantibodies in multiple sclerosis , 2000, Annals of neurology.

[111]  C. Boucsein,et al.  Electrophysiological properties of microglial cells in normal and pathologic rat brain slices , 2000, The European journal of neuroscience.

[112]  A. S. Segal,et al.  Close Association of the N Terminus of Kv1.3 with the Pore Region* , 2000, The Journal of Biological Chemistry.

[113]  B. Attali,et al.  Extracellular K+ and Opening of Voltage-Gated Potassium Channels Activate T Cell Integrin Function , 2000, The Journal of experimental medicine.

[114]  J. Simmen,et al.  Brain insulin receptor causes activity-dependent current suppression in the olfactory bulb through multiple phosphorylation of Kv1.3. , 2000, Journal of neurophysiology.

[115]  P. Stastny,et al.  Desmoglein-1-specific T lymphocytes from patients with endemic pemphigus foliaceus (fogo selvagem). , 2000, The Journal of clinical investigation.

[116]  J. Bluestone,et al.  Pathologic Role and Temporal Appearance of Newly Emerging Autoepitopes in Relapsing Experimental Autoimmune Encephalomyelitis1 , 2000, The Journal of Immunology.

[117]  K. Chandy,et al.  Structure-guided Transformation of Charybdotoxin Yields an Analog That Selectively Targets Ca2+-activated over Voltage-gated K+ Channels* , 2000, The Journal of Biological Chemistry.

[118]  T. Nishikawa,et al.  Detection of antigen-specific B cells in patients with pemphigus vulgaris by enzyme-linked immunospot assay: requirement of T cell collaboration for autoantibody production. , 2000, The Journal of investigative dermatology.

[119]  G. Wolswijk Oligodendrocyte survival, loss and birth in lesions of chronic-stage multiple sclerosis. , 2000, Brain : a journal of neurology.

[120]  G A Gutman,et al.  A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies. , 1999, Trends in pharmacological sciences.

[121]  J. S. Choi,et al.  Mechanism of fluoxetine block of cloned voltage-activated potassium channel Kv1.3. , 1999, The Journal of pharmacology and experimental therapeutics.

[122]  J. Liu,et al.  Binding of correolide to K(v)1 family potassium channels. Mapping the domains of high affinity interaction. , 1999, The Journal of biological chemistry.

[123]  J. Newcombe,et al.  Subunit Composition of Kv1 Channels in Human CNS , 1999, Journal of neurochemistry.

[124]  H Rauer,et al.  Structural Conservation of the Pores of Calcium-activated and Voltage-gated Potassium Channels Determined by a Sea Anemone Toxin* , 1999, The Journal of Biological Chemistry.

[125]  B. Rudy,et al.  The Effects of Shaker β-Subunits on the Human Lymphocyte K+ Channel Kv1.3* , 1999, The Journal of Biological Chemistry.

[126]  S. Bromley,et al.  The immunological synapse: a molecular machine controlling T cell activation. , 1999, Science.

[127]  R. Vianna-Jorge,et al.  Peptidyl inhibitors of shaker-type Kv1 channels elicit twitches in guinea pig ileum by blocking kv1.1 at enteric nervous system and enhancing acetylcholine release. , 1999, The Journal of pharmacology and experimental therapeutics.

[128]  O. Hensens,et al.  Identification and biochemical characterization of a novel nortriterpene inhibitor of the human lymphocyte voltage-gated potassium channel, Kv1.3. , 1999, Biochemistry.

[129]  D. Choi,et al.  NMDA receptor-mediated K+ efflux and neuronal apoptosis. , 1999, Science.

[130]  Sungkwon Chung,et al.  Inward and outward rectifying potassium currents set membrane potentials in activated rat microglia , 1999, Neuroscience Letters.

[131]  M. Guenounou,et al.  HIV‐1 gp160 decreases the K+ voltage‐gated current from Jurkat E6.1 T cells by up‐phosphorylation , 1999, FEBS letters.

[132]  J. Burns,et al.  Isolation of myelin basic protein–specific T cells predominantly from the memory T‐cell compartment in multiple sclerosis , 1999, Annals of neurology.

[133]  E. Christian,et al.  ShK-Dap22, a Potent Kv1.3-specific Immunosuppressive Polypeptide* , 1998, The Journal of Biological Chemistry.

[134]  E. Joe,et al.  Expression of Kv 1 . 5 K 1 Channels in Activated Microglia In Vivo , 1998 .

[135]  Y. Oomura,et al.  Induction of outward current by orexin‐B in mouse peritoneal macrophages , 1998, FEBS letters.

[136]  U. Wagner,et al.  Perturbation of the T cell repertoire in rheumatoid arthritis. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[137]  S. Grissmer,et al.  Alkoxypsoralens, novel nonpeptide blockers of Shaker-type K+ channels: synthesis and photoreactivity. , 1998, Journal of medicinal chemistry.

[138]  K. Rajewsky,et al.  Human Immunoglobulin (Ig)M+IgD+ Peripheral Blood B Cells Expressing the CD27 Cell Surface Antigen Carry Somatically Mutated Variable Region Genes: CD27 as a General Marker for Somatically Mutated (Memory) B Cells , 1998, The Journal of experimental medicine.

[139]  R. Tisch,et al.  B lymphocytes are critical antigen-presenting cells for the initiation of T cell-mediated autoimmune diabetes in nonobese diabetic mice. , 1998, Journal of immunology.

[140]  I. Levitan,et al.  Modulation of Olfactory Bulb Neuron Potassium Current by Tyrosine Phosphorylation , 1998, The Journal of Neuroscience.

[141]  Kuhlmann,et al.  Identification of glial cell proliferation in early multiple sclerosis lesions , 1998, Neuropathology and applied neurobiology.

[142]  W. Waldhäusl,et al.  Elevated CD69 expression on naive peripheral blood T-cells in hyperthyroid Graves' disease and autoimmune thyroiditis: discordant effect of methimazole on HLA-DR and CD69. , 1998, Clinical immunology and immunopathology.

[143]  B. Chait,et al.  Structural conservation in prokaryotic and eukaryotic potassium channels. , 1998, Science.

[144]  H. Kolb,et al.  Transfer of diabetes type 1 by bone-marrow transplantation , 1998, The Lancet.

[145]  C. June,et al.  Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. A marker of activated/memory T cells. , 1998 .

[146]  A. Koschak,et al.  Subunit Composition of Brain Voltage-gated Potassium Channels Determined by Hongotoxin-1, a Novel Peptide Derived fromCentruroides limbatus Venom* , 1998, The Journal of Biological Chemistry.

[147]  M. Péter,et al.  Pandinus imperator scorpion venom blocks voltage-gated K+ channels in human lymphocytes. , 1998, Biochemical and biophysical research communications.

[148]  D. G. Green,et al.  Serum‐induced changes in the physiology of mammalian retinal glial cells: role of lysophosphatidic acid , 1998, The Journal of physiology.

[149]  E. Christian,et al.  A Novel Gene, hKCa4, Encodes the Calcium-activated Potassium Channel in Human T Lymphocytes* , 1997, The Journal of Biological Chemistry.

[150]  O. Pongs,et al.  A four-disulphide-bridged toxin, with high affinity towards voltage-gated K+ channels, isolated from Heterometrus spinnifer (Scorpionidae) venom. , 1997, The Biochemical journal.

[151]  E. Joe,et al.  Expression and function of outward K+ channels induced by lipopolysaccharide in microglia. , 1997, Molecules and cells.

[152]  K. Chandy,et al.  Human Homologue of the Drosophila Discs Large Tumor Suppressor Binds to p56 lck Tyrosine Kinase and Shaker Type Kv1.3 Potassium Channel in T Lymphocytes* , 1997, The Journal of Biological Chemistry.

[153]  I. Levitan,et al.  Tyrosine phosphorylation modulates current amplitude and kinetics of a neuronal voltage-gated potassium channel. , 1997, Journal of neurophysiology.

[154]  U. Heinemann,et al.  Pharmacological properties of Ca2+-activated K+ currents of ramified murine brain macrophages , 1997, Naunyn-Schmiedeberg's Archives of Pharmacology.

[155]  N. Sigal,et al.  Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo. , 1997, Journal of immunology.

[156]  Christopher C. Goodnow,et al.  Differential activation of transcription factors induced by Ca2+ response amplitude and duration , 1997, Nature.

[157]  G. Kaczorowski,et al.  Margatoxin binds to a homomultimer of K(V)1.3 channels in Jurkat cells. Comparison with K(V)1.3 expressed in CHO cells. , 1997, Biochemistry.

[158]  F. Lang,et al.  Inhibitory effects of oxidants on n-type K+ channels in T lymphocytes and Xenopus oocytes , 1997, Pflügers Archiv.

[159]  C. Vita,et al.  A potassium-channel toxin from the sea anemone Bunodosoma granulifera, an inhibitor for Kv1 channels. Revision of the amino acid sequence, disulfide-bridge assignment, chemical synthesis, and biological activity. , 1997, European journal of biochemistry.

[160]  G. Levi,et al.  Protein kinase C involvement in the resting and interferon‐γ‐induced K+ channel profile of microglial cells , 1997, Journal of neuroscience research.

[161]  F. Lombardo,et al.  Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings , 1997 .

[162]  H. Korn,et al.  Enhancement of calcium signaling and proliferation responses in activated human T lymphocytes. Inhibitory effects of K+ channel block by charybdotoxin depend on the T cell activation state. , 1997, Cell calcium.

[163]  P Stastny,et al.  Development and characterization of desmoglein-3 specific T cells from patients with pemphigus vulgaris. , 1997, The Journal of clinical investigation.

[164]  I. Khaytin,et al.  An essential binding surface for ShK toxin interaction with rat brain potassium channels. , 1996, Biochemistry.

[165]  R. J. Mather,et al.  Novel nonpeptide agents potently block the C-type inactivated conformation of Kv1.3 and suppress T cell activation. , 1996, Molecular pharmacology.

[166]  S. Grissmer,et al.  Evidence for an internal phenylalkylamine action on the voltage-gated potassium channel Kv1.3. , 1996, Molecular pharmacology.

[167]  H. Rochat,et al.  Chemical synthesis and characterization of maurotoxin, a short scorpion toxin with four disulfide bridges that acts on K+ channels. , 1996, European journal of biochemistry.

[168]  J. Seita,et al.  Murine peritoneal macrophages induce a novel 60-kDa protein with structural similarity to a tyrosine kinase p56lck-associated protein in response to oxidative stress. , 1996, Biochemical and biophysical research communications.

[169]  O. Pongs,et al.  Tyrosine Phosphorylation-dependent Suppression of a Voltage-gated K+ Channel in T Lymphocytes upon Fas Stimulation* , 1996, The Journal of Biological Chemistry.

[170]  B. Ballyk,et al.  Properties of K+ and Cl− channels and their involvement in proliferation of rat microglial cells , 1996 .

[171]  F. N. Quandt,et al.  III. Ion Channel Expression in PMA-differentiated Human THP-1 Macrophages , 1996, The Journal of Membrane Biology.

[172]  T. DeCoursey,et al.  II. Voltage-activated Proton Currents in Human THP-1 Monocytes , 1996, The Journal of Membrane Biology.

[173]  J. C. Mateos,et al.  Voltage-dependent potassium channels in white adipocytes. , 1996, Biochemical and biophysical research communications.

[174]  J. Strominger,et al.  Molecular cloning of a phosphotyrosine-independent ligand of the p56lck SH2 domain. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[175]  H. Strauss,et al.  In situ hybridization reveals extensive diversity of K+ channel mRNA in isolated ferret cardiac myocytes. , 1996, Circulation research.

[176]  U. Heinemann,et al.  Proton modulation of outward K+ currents in interferon-γ-activated microglia , 1996, Neuroscience Letters.

[177]  U. Wittstock,et al.  Cicutoxin from Cicuta virosa--a new and potent potassium channel blocker in T lymphocytes. , 1996, Biochemical and biophysical research communications.

[178]  S. Gregory,et al.  T cell activation is regulated by voltage-dependent and calcium-activated potassium channels. , 1996, Journal of immunology.

[179]  Christopher Miller,et al.  A Strongly Interacting Pair of Residues on the Contact Surface of Charybdotoxin and a Shaker K+ Channel , 1996, Neuron.

[180]  I. Khaytin,et al.  Chemical synthesis and characterization of ShK toxin: a potent potassium channel inhibitor from a sea anemone. , 2009, International journal of peptide and protein research.

[181]  L. Pinto,et al.  Identification and localization of K+ channels in the mouse retina , 1995, Visual Neuroscience.

[182]  James E. Hall,et al.  Topology of the pore-region of a K+ channel revealed by the NMR-derived structures of scorpion toxins , 1995, Neuron.

[183]  B. Freedman,et al.  Identification of Kv1.1 Expression by Murine CD4−CD8− Thymocytes , 1995, The Journal of Biological Chemistry.

[184]  C. Deutsch,et al.  C-type inactivation of a voltage-gated K+ channel occurs by a cooperative mechanism. , 1995, Biophysical journal.

[185]  C. Jun,et al.  Intracellular Ca2+ pool depletion is linked to the induction of nitric oxide synthesis in murine peritoneal macrophages. , 1995, Biochemistry and molecular biology international.

[186]  R. MacKinnon,et al.  Solution structure of the potassium channel inhibitor agitoxin 2: Caliper for probing channel geometry , 1995, Protein science : a publication of the Protein Society.

[187]  R. J. Hill,et al.  WIN 17317-3: novel nonpeptide antagonist of voltage-activated K+ channels in human T lymphocytes. , 1995, Molecular pharmacology.

[188]  S. Ito,et al.  The Shaker-like potassium channels of the mouse rod bipolar cell and their contributions to the membrane current , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[189]  C. Wernstedt,et al.  Characterization of a potassium channel toxin from the Caribbean Sea anemone Stichodactyla helianthus. , 1995, Toxicon : official journal of the International Society on Toxinology.

[190]  R. MacKinnon,et al.  Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor. , 1995, Science.

[191]  H. Vijverberg,et al.  Intracellular Ca2+ oscillations and membrane potential fluctuations in intact human T lymphocytes: role of K+ channels in Ca2+ signaling. , 1995, Cell calcium.

[192]  M. P. Mahaut-Smith Calcium‐activated potassium channels in human platelets. , 1995, The Journal of physiology.

[193]  R. Lewis,et al.  Rapid inactivation of depletion-activated calcium current (ICRAC) due to local calcium feedback , 1995, The Journal of general physiology.

[194]  B. A. Johnson,et al.  Determination of the three-dimensional structure of margatoxin by 1H, 13C, 15N triple-resonance nuclear magnetic resonance spectroscopy. , 1994, Biochemistry.

[195]  S. Judge,et al.  IKir regulation in murine macrophages: whole cell and perforated patch studies. , 1994, The American journal of physiology.

[196]  J. Stokes,et al.  Functional and molecular evidence for Shaker-like K+ channels in rabbit renal papillary epithelial cell line. , 1994, The American journal of physiology.

[197]  K. Bohuslavizki,et al.  Mode of action of psoralens, benzofurans, acridinons, and coumarins on the ionic currents in intact myelinated nerve fibres and its significance in demyelinating diseases. , 1994, General physiology and biophysics.

[198]  R. MacKinnon,et al.  Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom. , 1994, Biochemistry.

[199]  Christopher Miller,et al.  The charybdotoxin receptor of a Shaker K+ channel: Peptide and channel residues mediating molecular recognition , 1994, Neuron.

[200]  M. Bednarek,et al.  Chemical synthesis and structure-function studies of margatoxin, a potent inhibitor of voltage-dependent potassium channel in human T lymphocytes. , 1994, Biochemical and biophysical research communications.

[201]  L. Kolmakova-Partensky,et al.  Intimations of K+ channel structure from a complete functional map of the molecular surface of charybdotoxin. , 1994 .

[202]  C. Miller,et al.  Mechanism of charybdotoxin block of a voltage-gated K+ channel. , 1993, Biophysical journal.

[203]  S. Grissmer,et al.  Calcium-activated potassium channels in resting and activated human T lymphocytes. Expression levels, calcium dependence, ion selectivity, and pharmacology , 1993, The Journal of general physiology.

[204]  P. Gebicke-haerter,et al.  Expression of an outwardly rectifying K+ channel in rat microglia cultivated on teflon , 1993, Neuroscience Letters.

[205]  M. Garcia-Calvo,et al.  Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels. , 1993, The Journal of biological chemistry.

[206]  H. Korn,et al.  Pattern of potassium channel expression in proliferating B lymphocytes depends upon the mode of activation. , 1993, Journal of immunology.

[207]  K. Hara,et al.  Immunohistological analysis of memory T lymphocytes and activated B lymphocytes in tissues with periodontal disease. , 1993, Journal of periodontal research.

[208]  T. Chused,et al.  Lack of voltage sensitive potassium channels and generation of membrane potential by sodium potassium ATPase in murine T lymphocytes. , 1993, Journal of immunology.

[209]  R. Lewis,et al.  Mitogen-regulated Ca2+ current of T lymphocytes is activated by depletion of intracellular Ca2+ stores. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[210]  H. Kolb,et al.  Transfer of insulin-dependent diabetes between HLA-identical siblings by bone marrow transplantation , 1993, The Lancet.

[211]  U. Hellman,et al.  A potassium channel toxin from the secretion of the sea anemone Bunodosoma granulifera. Isolation, amino acid sequence and biological activity. , 1993, Biochimica et biophysica acta.

[212]  S. Todesco,et al.  Early phenotypic activation of circulating helper memory T cells in scleroderma: correlation with disease activity. , 1993, Annals of the rheumatic diseases.

[213]  Yoshihiro Kubo,et al.  Primary structure and functional expression of a mouse inward rectifier potassium channel , 1993, Nature.

[214]  A. Reimers,et al.  Reduction of MS-related scotomata by a new class of potassium channel blockers from Ruta graveolens , 1993 .

[215]  B. Freedman,et al.  Evidence for voltage modulation of IL-2 production in mitogen-stimulated human peripheral blood lymphocytes. , 1992, Journal of immunology.

[216]  W. Kues,et al.  Heterogeneous Expression Patterns of Mammalian Potassium Channel Genes in Developing and Adult Rat Brain , 1992, The European journal of neuroscience.

[217]  Chul-Seung Park,et al.  Interaction of charybdotoxin with permeant ions inside the pore of a K+ channel , 1992, Neuron.

[218]  H. Korn,et al.  Differential regulation of voltage- and calcium-activated potassium channels in human B lymphocytes. , 1992, Journal of immunology.

[219]  M. Lazdunski,et al.  Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes. , 1992, The Journal of biological chemistry.

[220]  C. Miller,et al.  A point mutation in a Shaker K+ channel changes its charybdotoxin binding site from low to high affinity. , 1992, Biophysical journal.

[221]  J. McPherson,et al.  Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1. , 1992, Genomics.

[222]  G. Kreutzberg,et al.  A subpopulation of bone marrow‐derived macrophage‐like cells shares a unique ion channel pattern with microglia , 1991, Journal of neuroscience research.

[223]  C. Deutsch,et al.  Characterization of high affinity binding sites for charybdotoxin in human T lymphocytes. Evidence for association with the voltage-gated K+ channel. , 1991, The Journal of biological chemistry.

[224]  C. Roumestand,et al.  Three-dimensional structure of natural charybdotoxin in aqueous solution by 1H-NMR. Charybdotoxin possesses a structural motif found in other scorpion toxins. , 1991, European journal of biochemistry.

[225]  H. Korn,et al.  Ion channels and B cell mitogenesis. , 1990, Molecular immunology.

[226]  A. L. Goldin,et al.  Expression and chromosomal localization of a lymphocyte K+ channel gene. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[227]  R. MacKinnon,et al.  Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor , 1990, Neuron.

[228]  M P Mahaut-Smith,et al.  Voltage‐gated potassium channels and the control of membrane potential in human platelets. , 1990, The Journal of physiology.

[229]  G. Kreutzberg,et al.  Cultured microglial cells have a distinct pattern of membrane channels different from peritoneal macrophages , 1990, Journal of neuroscience research.

[230]  C. Brosnan,et al.  Homing to central nervous system vasculature by antigen-specific lymphocytes. I. Localization of 14C-labeled cells during acute, chronic, and relapsing experimental allergic encephalomyelitis. , 1990, Laboratory investigation; a journal of technical methods and pathology.

[231]  J. Adelman,et al.  Characterization and functional expression of a rat genomic DNA clone encoding a lymphocyte potassium channel. , 1990, Journal of immunology.

[232]  Bart O. Roep,et al.  T-cell clones from a type-1 diabetes patient respond to insulin secretory granule proteins , 1990, Nature.

[233]  L. Kaczmarek,et al.  Cloning and expression of cDNA and genomic clones encoding three delayed rectifier potassium channels in rat brain , 1990, Neuron.

[234]  H. Korn,et al.  Ion channel blockers inhibit B cell activation at a precise stage of the G1 phase of the cell cycle. Possible involvement of K+ channels. , 1990, Journal of immunology.

[235]  G A Gutman,et al.  A family of three mouse potassium channel genes with intronless coding regions. , 1990, Science.

[236]  R J Albertini,et al.  T cells responsive to myelin basic protein in patients with multiple sclerosis. , 1990, Science.

[237]  R. Horn,et al.  Phencyclidine blocks voltage-dependent potassium currents in murine thymocytes. , 1990, The Journal of pharmacology and experimental therapeutics.

[238]  C. Deutsch,et al.  Charybdotoxin inhibits proliferation and interleukin 2 production in human peripheral blood lymphocytes. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[239]  B. Sakmann,et al.  Molecular basis of functional diversity of voltage‐gated potassium channels in mammalian brain. , 1989, The EMBO journal.

[240]  R. MacKinnon,et al.  Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor. , 1989, Science.

[241]  L. Schlichter,et al.  Ca2(+)‐activated K+ channels in human B lymphocytes and rat thymocytes. , 1989, The Journal of physiology.

[242]  M. Cahalan,et al.  Charybdotoxin blocks voltage-gated K+ channels in human and murine T lymphocytes , 1989, The Journal of general physiology.

[243]  L. Samelson,et al.  Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck , 1989, Nature.

[244]  M. Cahalan,et al.  Voltage-sensitive ion channels in human B lymphocytes. , 1989, Advances in experimental medicine and biology.

[245]  S. Gollapudi,et al.  Effect of K+ channel blockers on anti-immunoglobulin-induced murine B cell proliferation. , 1988, Journal of clinical & laboratory immunology.

[246]  Michael A. Bookman,et al.  The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56 lck , 1988, Cell.

[247]  Sherwin C. Lee,et al.  Volume response of quiescent and interleukin 2-stimulated T-lymphocytes to hypotonicity. , 1988, The American journal of physiology.

[248]  M. Cahalan,et al.  Role of potassium and chloride channels in volume regulation by T lymphocytes. , 1988, Society of General Physiologists series.

[249]  K. Chandy,et al.  Mitogen induction of ion channels in murine T lymphocytes , 1987, The Journal of general physiology.

[250]  K. Chandy,et al.  Altered K+ channel expression in abnormal T lymphocytes from mice with the lpr gene mutation. , 1986, Science.

[251]  S. Hagiwara,et al.  Potassium channels in human NK cells are involved in discrete stages of the killing process. , 1986, Journal of immunology.

[252]  C. Deutsch,et al.  Increased voltage-gated potassium conductance during interleukin 2- stimulated proliferation of a mouse helper T lymphocyte clone , 1986, The Journal of cell biology.

[253]  C. Deutsch,et al.  Voltage‐gated potassium conductance in human T lymphocytes stimulated with phorbol ester. , 1986, The Journal of physiology.

[254]  P. Sheehy,et al.  Differential expression of inward and outward potassium currents in the macrophage‐like cell line J774.1. , 1985, The Journal of physiology.

[255]  K. Chandy,et al.  Voltage-dependent ion channels in T-lymphocytes , 1985, Journal of Neuroimmunology.

[256]  K. Chandy,et al.  Electroimmunology: the physiologic role of ion channels in the immune system. , 1985, Journal of immunology.

[257]  A. Harvey,et al.  Dendrotoxins: snake toxins that block potassium channels and facilitate neurotransmitter release. , 1985, Pharmacology & therapeutics.

[258]  Gallin Ek Electrophysiological properties of macrophages. , 1984 .

[259]  S. Hagiwara,et al.  Potassium current in clonal cytotoxic T lymphocytes from the mouse. , 1984, The Journal of physiology.

[260]  K. Chandy,et al.  Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis? , 1984, Nature.

[261]  I. Cohen,et al.  Experimental autoimmune encephalomyelitis (EAE) mediated by T cell lines: process of selection of lines and characterization of the cells. , 1982, Journal of immunology.

[262]  E. Gallin Voltage clamp studies in macrophages from mouse spleen cultures. , 1981, Science.

[263]  D. J. Strydom Snake venom toxins. Purification and properties of low-molecular-weight polypeptides of Dendroaspis polylepis polylepis (black mamba) venom. , 1976, European journal of biochemistry.

[264]  C. Hansch,et al.  The effect of intramolecular bydrophobic bonding on partition coefficients , 1967 .