Increased Overall Antibiotic Susceptibility inStaphylococcus aureus femAB Null Mutants

ABSTRACT The staphylococcal pentaglycine side chain of the peptidoglycan is reduced to one glycine in femAB null mutants. This is associated with increased susceptibility to methicillin and to a whole range of unrelated antibiotics as well. Genetic evidence suggests thatfemAB null mutants are only viable because of a compensatory mutation in an unlinked site.

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