Relationship of solar keratosis and history of skin cancer to objective measures of actinic skin damage

Two methods for the assessment of severity of actinic skin damage were evaluated in a population‐based survey of 1216 subjects. After controlling for the effects of age, skin texture changes graded by cutaneous microtopography were found to be associated strongly with the presence of solar keratoses and a past history of non‐melanotic skin cancer. Changes in skin condition graded by paraocular photography had a weaker relationship with the presence of keratoses and showed no association with non‐melanotic skin cancer. These results, together with a higher level of agreement between observers in grading cutaneous microtopographs, support the use of cutaneous microtopography as an index of actinic skin damage in epidemiological research.

[1]  T. Fears,et al.  Mathematical models of age and ultraviolet effects on the incidence of skin cancer among whites in the United States. , 1977, American journal of epidemiology.

[2]  Nathan Mantel,et al.  Chi-square tests with one degree of freedom , 1963 .

[3]  C. Holman,et al.  An improved method of analysis of observer variation between pathologists , 1982, Histopathology.

[4]  J. Barbenel,et al.  A quantitative method for the assessment of the microtopography of human skin. , 1979, Acta dermato-venereologica.

[5]  H. Daniell.  Smoker's wrinkles. A study in the epidemiology of "crow's feet". , 1971, Annals of internal medicine.

[6]  C. Holman,et al.  Inter‐observer variation in the histopathological reporting of Hodgkin's disease: an analysis of diagnostic subcomponents using kappa statistics , 1983, Histopathology.

[7]  P. Cutchis.  ON THE LINKAGE OF SOLAR ULTRAVIOLET RADIATION TO SKIN CANCER , 1978 .

[8]  T. Smith.  The Queensland Melanoma Project--an exercise in health education. , 1979, British medical journal.

[9]  J. Fleiss,et al.  Intraclass correlations: uses in assessing rater reliability. , 1979, Psychological bulletin.

[10]  G. Carmichael.  A Survey of Skin Cancers and Solar Kératoses in Country Areas in Queensland. , 1962 .

[11]  I. Sarkany.  A METHOD FOR STUDYING THE MICROTOPOGRAPHY OF THE SKIN. , 1962, The British journal of dermatology.

[12]  F. Urbach,et al.  The relative importance of risk factors in nonmelanoma carcinoma. , 1980, Archives of dermatology.

[13]  I. Barnes.  Techniques for the replication of skin surfaces , 1973, The British journal of dermatology.

[14]  Whiting Da.  Skin tumours in white South Africans. Part IV. Influence of occupation, sun sensitivity, colouring and associated skin tumours on the incidence of skin tumours. , 1978 .

[15]  J. Richard Landis,et al.  Large sample variance of kappa in the case of different sets of raters. , 1979 .