Serum and CSF PDGF‐AA and FGF‐2 in relapsing‐remitting multiple sclerosis: a case–control study

Background and purpose:  Fibroblast growth factor‐2 (FGF‐2) and platelet‐derived growth factor‐A (PDGF‐AA) are potent modulators of oligodendrocytes, the main responsible cells for myelin regeneration. We measured FGF‐2 and PDGF‐AA in the sera and cerebrospinal fluid (CSF) of patients with relapsing‐remitting multiple sclerosis (RR‐MS) and compared these values with control subjects.

[1]  P. Calabresi,et al.  Fibroblast growth factor-2 levels are elevated in the cerebrospinal fluid of multiple sclerosis patients , 2008, Neuroscience Letters.

[2]  M. Ballmaier,et al.  Up‐regulation of platelet‐derived growth factor by peripheral‐blood leukocytes during experimental allergic encephalomyelitis , 2008, Journal of neuroscience research.

[3]  R. Armstrong,et al.  Platelet-Derived Growth Factor Promotes Repair of Chronically Demyelinated White Matter , 2007, Journal of neuropathology and experimental neurology.

[4]  J. McQualter,et al.  Multiple sclerosis: a battle between destruction and repair , 2007, Journal of neurochemistry.

[5]  F. Mihara,et al.  Upregulation of vascular growth factors in multiple sclerosis: Correlation with MRI findings , 2006, Journal of the Neurological Sciences.

[6]  R. Armstrong,et al.  PDGF and FGF2 pathways regulate distinct oligodendrocyte lineage responses in experimental demyelination with spontaneous remyelination , 2005, Neurobiology of Disease.

[7]  A. Butt,et al.  Fibroblast growth factor 2 induces loss of adult oligodendrocytes and myelin in vivo , 2005, Experimental Neurology.

[8]  B. Weinshenker,et al.  Natural history of multiple sclerosis. , 2005, Neurologic clinics.

[9]  J. Goldman,et al.  Oligodendrocytes and progenitors become progressively depleted within chronically demyelinated lesions. , 2004, The American journal of pathology.

[10]  W. Richardson,et al.  Platelet-derived growth factor regulates oligodendrocyte progenitor numbers in adult CNS and their response following CNS demyelination , 2004, Molecular and Cellular Neuroscience.

[11]  M. Cuzner,et al.  Role for TGF‐β1, FGF‐2 and PDGF‐AA in a myelination of CNS aggregate cultures enriched with macrophages , 2003, Journal of neuroscience research.

[12]  Alireza Minagar,et al.  Blood-brain barrier disruption in multiple sclerosis , 2003, Multiple sclerosis.

[13]  W. Pan,et al.  Different mechanisms influencing permeation of PDGF‐AA and PDGF‐BB across the blood–brain barrier , 2003, Journal of neurochemistry.

[14]  R. Armstrong,et al.  PDGF and FGF2 regulate oligodendrocyte progenitor responses to demyelination† , 2003, Journal of neurobiology.

[15]  Robin J. M. Franklin,et al.  Why does remyelination fail in multiple sclerosis? , 2002, Nature Reviews Neuroscience.

[16]  G. Wolswijk,et al.  Oligodendrocyte precursor cells in the demyelinated multiple sclerosis spinal cord. , 2002, Brain : a journal of neurology.

[17]  M. Berry,et al.  Fibroblast growth factor‐2 induces astroglial and microglial reactivity in vivo , 2002, Journal of anatomy.

[18]  R. Quarles,et al.  Differences in signal transduction pathways by which platelet‐derived and fibroblast growth factors activate extracellular signal‐regulated kinase in differentiating oligodendrocytes , 2001, Journal of neurochemistry.

[19]  L. Roccatagliata,et al.  Demyelination and axonal damage in a non-human primate model of multiple sclerosis , 2001, Journal of the Neurological Sciences.

[20]  F. Mascarelli,et al.  Central nervous system distribution of fibroblast growth factor injected into the blood stream. , 1996, Neurological research.

[21]  C. Heldin,et al.  Expression of Platelet-Derived Growth Factor (PDGF) and PDGF α- and β-Receptors in the Peripheral Nervous System: An Analysis of Sciatic Nerve and Dorsal Root Ganglia , 1993 .

[22]  T. Matsui,et al.  A Role for Fibroblast Growth Factor in Oligodendrocyte Development , 1991, Annals of the New York Academy of Sciences.

[23]  O. Bogler,et al.  Cooperation between two growth factors promotes extended self-renewal and inhibits differentiation of oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[24]  Y. Itoyama,et al.  Schwann cell remyelination of demyelinated axons in spinal cord multiple sclerosis lesions , 1983, Annals of neurology.

[25]  M. Pollock,et al.  Peripheral nerve abnormality in multiple sclerosis , 1977, Annals of neurology.