Effects of Stenosis on the Porcine Left Anterior Descending Arterial Tree

In this study, hemodynamics in the normal and diseased left anterior descending (LAD) arterial trees were compared to estimate the effects of stenosis on the flow rate distribution, detailed flow field and wall shear stress (WSS) distributions on both transient and steady flow conditions. The anatomical model was reconstructed from computed tomography (CT) images of a normal porcine heart. Stenosis was imposed at the trunk of LAD tree with different area stenosis ratios (25%, 50%, 75% and 90%) to study the effect of stenosis. It has been found that the steady-state simulation is competent to demonstrate the prominent flow features of transit flow. Only significant stenosis altered the flow rate considerably, and its effects diminished at the downstream bifurcations. Based on the WSS distribution, non-significant stenosis potentially led to the development of atherosclerosis near the ostium of the downstream side branch and significant stenosis might promote atherosclerosis in its wake.

[1]  Charles A. Taylor,et al.  On Coupling a Lumped Parameter Heart Model and a Three-Dimensional Finite Element Aorta Model , 2009, Annals of Biomedical Engineering.

[2]  C. D. Murray.  THE PHYSIOLOGICAL PRINCIPLE OF MINIMUM WORK , 1931, The Journal of general physiology.

[3]  Charles A. Taylor,et al.  Patient-Specific Modeling of Blood Flow and Pressure in Human Coronary Arteries , 2010, Annals of Biomedical Engineering.

[4]  Wei Yin,et al.  Effect of geometrical assumptions on numerical modeling of coronary blood flow under normal and disease conditions. , 2010, Journal of biomechanical engineering.

[5]  Nils P. Johnson,et al.  Coronary Branch Steal: Experimental Validation and Clinical Implications of Interacting Stenosis in Branching Coronary Arteries , 2010, Circulation Cardiovascular Imaging.

[6]  G. Kassab.  Scaling laws of vascular trees: of form and function. , 2006, American journal of physiology. Heart and circulatory physiology.

[7]  Thomas Wischgoll,et al.  Flow patterns in three-dimensional porcine epicardial coronary arterial tree. , 2007, American journal of physiology. Heart and circulatory physiology.

[8]  Vartan Kurtcuoglu,et al.  Choosing the optimal wall shear parameter for the prediction of plaque location-A patient-specific computational study in human left coronary arteries. , 2012, Atherosclerosis.

[9]  Vartan Kurtcuoglu,et al.  Choosing the optimal wall shear parameter for the prediction of plaque location-A patient-specific computational study in human right coronary arteries. , 2010, Atherosclerosis.

[10]  D. Gallo,et al.  On the Use of In Vivo Measured Flow Rates as Boundary Conditions for Image-Based Hemodynamic Models of the Human Aorta: Implications for Indicators of Abnormal Flow , 2012, Annals of Biomedical Engineering.

[11]  Ali Cemal Benim,et al.  Simulation of blood flow in human aorta with emphasis on outlet boundary conditions , 2011 .

[12]  C D Murray,et al.  The Physiological Principle of Minimum Work: I. The Vascular System and the Cost of Blood Volume. , 1926, Proceedings of the National Academy of Sciences of the United States of America.

[13]  Frans N van de Vosse,et al.  MRI-based quantification of outflow boundary conditions for computational fluid dynamics of stenosed human carotid arteries. , 2010, Journal of biomechanics.

[14]  Patrick Segers,et al.  Effect of the degree of LAD stenosis on “competitive flow” and flow field characteristics in LIMA-to-LAD bypass surgery , 2012, Medical & Biological Engineering & Computing.

[15]  B. Kuban,et al.  Validated computation of physiologic flow in a realistic coronary artery branch. , 1997, Journal of biomechanics.

[16]  N Karcanias,et al.  Vortex formation and recirculation zones in left anterior descending artery stenoses: computational fluid dynamics analysis , 2010, Physics in medicine and biology.

[17]  G. Louridas,et al.  Wall shear stress in normal left coronary artery tree. , 2006, Journal of biomechanics.