A review of the surgical options for the correction of presbyopia

Presbyopia is an age-related eye condition where one of the signs is the reduction in the amplitude of accommodation, resulting in the loss of ability to change the eye's focus from far to near. It is the most common age-related ailments affecting everyone around their mid-40s. Methods for the correction of presbyopia include contact lens and spectacle options but the surgical correction of presbyopia still remains a significant challenge for refractive surgeons. Surgical strategies for dealing with presbyopia may be extraocular (corneal or scleral) or intraocular (removal and replacement of the crystalline lens or some type of treatment on the crystalline lens itself). There are however a number of limitations and considerations that have limited the widespread acceptance of surgical correction of presbyopia. Each surgical strategy presents its own unique set of advantages and disadvantages. For example, lens removal and replacement with an intraocular lens may not be preferable in a young patient with presbyopia without a refractive error. Similarly treatment on the crystalline lens may not be a suitable choice for a patient with early signs of cataract. This article is a review of the options available and those that are in development stages and are likely to be available in the near future for the surgical correction of presbyopia.

[1]  A. Demirok,et al.  Intracorneal inlay to correct presbyopia: Long‐term results , 2011, Journal of cataract and refractive surgery.

[2]  M. Netto,et al.  Visual performance of an apodized diffractive multifocal intraocular lens with +3.00-d addition: 1-year follow-up. , 2011, Journal of refractive surgery.

[3]  David P Piñero,et al.  Correlation of visual performance with quality of life and intraocular aberrometric profile in patients implanted with rotationally asymmetric multifocal IOLs. , 2012, Journal of refractive surgery.

[4]  Arun D. Singh,et al.  Imaging Techniques for Uveal Melanoma , 2006, International ophthalmology clinics.

[5]  R. Pokroy,et al.  Monovision Surgery in Myopic Presbyopes: Visual Function and Satisfaction , 2013, Optometry and vision science : official publication of the American Academy of Optometry.

[6]  Mark Tomalla,et al.  Intrastromal femtosecond laser presbyopia correction: 1-year results of a multicenter study. , 2012, Journal of refractive surgery.

[7]  M. Knorz,et al.  Results of a European multicenter study of the True Vista bifocal intraocular lens , 1993, Journal of cataract and refractive surgery.

[8]  S. Jain,et al.  Success of monovision in presbyopes: review of the literature and potential applications to refractive surgery. , 1996, Survey of ophthalmology.

[9]  S. Riehemann,et al.  [Presbyopia treatment using a femtosecond laser]. , 2006, Der Ophthalmologe.

[10]  J. E. Slagsvold 3M diffractive multifocal intraocular lens: eight year follow-up. , 2000, Journal of cataract and refractive surgery.

[11]  P. Carpineto,et al.  Longterm results of 1 CU accommodative intraocular lens implantation: 2-year follow-up study. , 2007, Acta ophthalmologica Scandinavica.

[12]  David P Piñero,et al.  Visual outcomes and optical performance of a monofocal intraocular lens and a new‐generation multifocal intraocular lens , 2011, Journal of cataract and refractive surgery.

[13]  M. O'Keefe,et al.  Preloaded refractive‐addition corneal inlay to compensate for presbyopia implanted using a femtosecond laser: One‐year visual outcomes and safety , 2014, Journal of cataract and refractive surgery.

[14]  Charles D Reilly,et al.  Surgical Monovision and Monovision Reversal in LASIK , 2006, Cornea.

[15]  Jorge Benozzi,et al.  Presbyopia: a New Potential Pharmacological Treatment , 2012, Medical hypothesis, discovery & innovation ophthalmology journal.

[16]  D. Goldberg,et al.  Laser in situ keratomileusis monovision , 2001, Journal of cataract and refractive surgery.

[17]  Samuel Arba-Mosquera,et al.  One-Year Experience in Presbyopia Correction With Biaspheric Multifocal Central Presbyopia Laser In Situ Keratomileusis , 2013, Cornea.

[18]  A. Ehmer,et al.  Intraocular lens power calculation after intrastromal femtosecond laser treatment for presbyopia: Theoretic approach , 2011, Journal of cataract and refractive surgery.

[19]  Emma J. Berrow,et al.  Visual performance of a new bi-aspheric, segmented, asymmetric multifocal IOL. , 2014, Journal of refractive surgery.

[20]  P. Asbell,et al.  Treatment of Presbyopia With Conductive Keratoplasty®: Six-Month Results of the 1-Year United States FDA Clinical Trial , 2004, Cornea.

[21]  Anna Voskresenskaya,et al.  Initial results of trifocal diffractive IOL implantation , 2010, Graefe's Archive for Clinical and Experimental Ophthalmology.

[22]  Dan Z Reinstein,et al.  LASIK for hyperopic astigmatism and presbyopia using micro-monovision with the Carl Zeiss Meditec MEL80 platform. , 2009, Journal of refractive surgery.

[23]  Sotiris Plainis,et al.  Visual outcomes and safety of a refractive corneal inlay for presbyopia using femtosecond laser. , 2013, Journal of refractive surgery.

[24]  R. Guthoff,et al.  [Ultrasound biomicroscopy imaging of accommodative configuration changes in the presbyopic ciliary body]. , 1996, Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft.

[25]  Jorge L Alió,et al.  Visual and accommodative outcomes 1 year after implantation of an accommodating intraocular lens based on a new concept , 2009, Journal of cataract and refractive surgery.

[26]  Dimitra M. Portaliou,et al.  Real and Pseudoaccommodation in Accommodative Lenses , 2011, Journal of ophthalmology.

[27]  J. Davison,et al.  History and development of the apodized diffractive intraocular lens , 2006, Journal of cataract and refractive surgery.

[28]  Nhung X Nguyen,et al.  Measurement of accommodation after implantation of an accommodating posterior chamber intraocular lens , 2003, Journal of cataract and refractive surgery.

[29]  Cem Mesçi,et al.  Visual performances with monofocal, accommodating, and multifocal intraocular lenses in patients with unilateral cataract. , 2010, American journal of ophthalmology.

[30]  D. Roder,et al.  Cost-benefit analysis of multifocal IOLs versus monovision pseudophakia , 2009 .

[31]  V. Mcgilligan,et al.  Femtosecond laser in situ keratomileusis versus conductive keratoplasty to obtain monovision in patients with emmetropic presbyopia , 2010, Journal of cataract and refractive surgery.

[32]  Maria A. Woodward,et al.  Dissatisfaction after multifocal intraocular lens implantation , 2009, Journal of cataract and refractive surgery.

[33]  Orang Seyeddain,et al.  Refractive surgical correction of presbyopia with the AcuFocus small aperture corneal inlay: two-year follow-up. , 2010, Journal of refractive surgery.

[34]  D. Uthoff,et al.  A new method of cornea modulation with excimer laser for simultaneous correction of presbyopia and ametropia , 2012, Graefe's Archive for Clinical and Experimental Ophthalmology.

[35]  Thomas Kohnen,et al.  European multicenter study of the AcrySof ReSTOR apodized diffractive intraocular lens. , 2006, Ophthalmology.

[36]  Stefan Nolte,et al.  Femtosecond laser treatment of the crystalline lens: a 1-year study of possible cataractogenesis in minipigs , 2011, Graefe's Archive for Clinical and Experimental Ophthalmology.

[37]  Samuel Arba Mosquera,et al.  Uncorrected binocular performance after biaspheric ablation profile for presbyopic corneal treatment using AMARIS with the PresbyMAX module. , 2013, American journal of ophthalmology.

[38]  S. Klyce,et al.  Corneal Inlays for the Treatment of Presbyopia , 2011, International ophthalmology clinics.

[39]  P. Asbell,et al.  Conductive keratoplasty for the correction of hyperopia. , 2001, Transactions of the American Ophthalmological Society.

[40]  M. Helal,et al.  One-site versus 2-site phacotrabeculectomy: a randomized study. , 1999, Journal of cataract and refractive surgery.

[41]  James S. Wolffsohn,et al.  Visual outcomes and subjective experience after bilateral implantation of a new diffractive trifocal intraocular lens , 2013, Journal of cataract and refractive surgery.

[42]  J. Alió,et al.  Quality of life evaluation after implantation of 2 multifocal intraocular lens models and a monofocal model , 2011, Journal of cataract and refractive surgery.

[43]  S. McLeod Optical principles, biomechanics, and initial clinical performance of a dual-optic accommodating intraocular lens (an American Ophthalmological Society thesis). , 2006, Transactions of the American Ophthalmological Society.

[44]  J L Semmlow,et al.  Age-related changes in human ciliary muscle and lens: a magnetic resonance imaging study. , 1999, Investigative ophthalmology & visual science.

[45]  Colm McAlinden,et al.  Multifocal intraocular lens with a surface‐embedded near section: Short‐term clinical outcomes , 2011, Journal of cataract and refractive surgery.

[46]  Mike P Holzer,et al.  Visual outcomes and corneal changes after intrastromal femtosecond laser correction of presbyopia , 2012, Journal of cataract and refractive surgery.

[47]  G. Baïkoff,et al.  Correction of presbyopia with refractive multifocal phakic intraocular lenses , 2004, Journal of cataract and refractive surgery.

[48]  Mark Packer,et al.  Clinical evaluation of the Crystalens AT‐45 accommodating intraocular lens: Results of the U.S. Food and Drug Administration clinical trial , 2006, Journal of cataract and refractive surgery.

[49]  R R Krueger,et al.  Novel approaches to correction of presbyopia with laser modification of the crystalline lens. , 1998, Journal of refractive surgery.

[50]  M. Kapadia,et al.  Binocular function and patient satisfaction after monovision induced by myopic photorefractive keratectomy. , 1999, Journal of cataract and refractive surgery.

[51]  Jorge L Alió,et al.  Presbyopia correction with an anterior chamber phakic multifocal intraocular lens. , 2005, Ophthalmology.

[52]  P. Chiam,et al.  Functional vision with bilateral ReZoom and ReSTOR intraocular lenses 6 months after cataract surgery , 2007, Journal of cataract and refractive surgery.

[53]  J. Venter,et al.  Initial experience with a new refractive rotationally asymmetric multifocal intraocular lens. , 2014, Journal of refractive surgery.

[54]  G. Mitchell,et al.  Comparison of Multifocal and Monovision Soft Contact Lens Corrections in Patients With Low-Astigmatic Presbyopia , 2006, Optometry and vision science : official publication of the American Academy of Optometry.

[55]  F. Malecaze,et al.  Scleral expansion bands for presbyopia. , 2001, Ophthalmology.

[56]  G. Grabner,et al.  Femtosecond laser–assisted small‐aperture corneal inlay implantation for corneal compensation of presbyopia: Two‐year follow‐up , 2013, Journal of cataract and refractive surgery.

[57]  Kamilla RUN JOHANNSDOTTIR,et al.  Monovision: a Review of the Scientific Literature , 2001, Optometry and vision science : official publication of the American Academy of Optometry.

[58]  D. Reinstein,et al.  LASIK for presbyopia correction in emmetropic patients using aspheric ablation profiles and a micro-monovision protocol with the Carl Zeiss Meditec MEL 80 and VisuMax. , 2012, Journal of refractive surgery.

[59]  S. Greenbaum Monovision pseudophakia , 2002, Journal of cataract and refractive surgery.

[60]  Sandra Gomez,et al.  One-year safety and efficacy results of a hydrogel inlay to improve near vision in patients with emmetropic presbyopia. , 2013, Journal of refractive surgery.

[61]  Angela Ehmer,et al.  Early outcomes of INTRACOR femtosecond laser treatment for presbyopia. , 2009, Journal of refractive surgery.

[62]  S. Jain,et al.  Monovision outcomes in presbyopic individuals after refractive surgery. , 2001, Ophthalmology.

[63]  G. Grabner,et al.  One‐year visual outcomes and patient satisfaction after surgical correction of presbyopia with an intracorneal inlay of a new design , 2012, Journal of cataract and refractive surgery.

[64]  H. Dick,et al.  Presbyopietherapie mit Femtosekundenlaser , 2006, Der Ophthalmologe.

[65]  M. J. Bautista,et al.  Visual outcomes after implantation of a refractive multifocal intraocular lens with a +3.00 D addition , 2010, Journal of cataract and refractive surgery.

[66]  R. Krueger,et al.  Monovision laser in situ keratomileusis for pre-presbyopic and presbyopic patients. , 2004, Journal of refractive surgery.

[67]  R. Yee,et al.  Scleral Expansion Procedure for the Correction of Presbyopia , 2006, International ophthalmology clinics.

[68]  A. Leccisotti,et al.  Secondary procedures after presbyopic lens exchange , 2004, Journal of cataract and refractive surgery.

[69]  D. Sanders,et al.  US FDA clinical trial of the Tetraflex potentially accommodating IOL: comparison to concurrent age-matched monofocal controls. , 2010, Journal of refractive surgery.

[70]  Gaetano Lodato,et al.  One-year outcomes with new-generation multifocal intraocular lenses. , 2008, Ophthalmology.

[71]  Sudi Patel,et al.  Correction of presbyopia by technovision central multifocal LASIK (presbyLASIK). , 2006, Journal of refractive surgery.

[72]  Richard H. Keates,et al.  Clinical results of the multifocal lens , 1987, Journal of cataract and refractive surgery.

[73]  M. Moshirfar,et al.  Comparing the Rate of Regression after Conductive Keratoplasty with or without Prior Laser-Assisted in situ Keratomileusis or Photorefractive Keratectomy , 2012, Middle East African journal of ophthalmology.

[74]  M. Packer,et al.  Evaluation of the aspheric tecnis multifocal intraocular lens: one-year results from the first cohort of the food and drug administration clinical trial. , 2010, American journal of ophthalmology.

[75]  L. Ruiz,et al.  Intrastromal correction of presbyopia using a femtosecond laser system. , 2009, Journal of refractive surgery.

[76]  Luis G. Vargas,et al.  Synchrony dual‐optic accommodating intraocular lens: Part 2: Pilot clinical evaluation , 2007, Journal of cataract and refractive surgery.

[77]  Ike K Ahmed,et al.  Review of Presbyopic IOLs: Multifocal and Accommodating IOLs , 2012, International ophthalmology clinics.

[78]  D. Lin,et al.  Two‐year results of conductive keratoplasty for the correction of low to moderate hyperopia , 2003, Journal of cataract and refractive surgery.

[79]  F. Roy,et al.  Mechanism of accommodation in primates. , 2001, Ophthalmology.

[80]  Holger Lubatschowski,et al.  Femtosecond laser induced flexibility change of human donor lenses , 2009, Vision Research.

[81]  Mujtaba A. Qazi,et al.  Implantation of scleral expansion band segments for the treatment of presbyopia. , 2003, American journal of ophthalmology.

[82]  T. Tsuru,et al.  Simultaneous corneal inlay implantation and laser in situ keratomileusis for presbyopia in patients with hyperopia, myopia, or emmetropia: Six‐month results , 2012, Journal of cataract and refractive surgery.

[83]  Marine Gobbe,et al.  LASIK for Myopic Astigmatism and Presbyopia Using Non-Linear Aspheric Micro-Monovision with the Carl Zeiss Meditec MEL 80 Platform. , 2011, Journal of refractive surgery.

[84]  Jorge L Alió,et al.  Outcomes of a new diffractive trifocal intraocular lens , 2014, Journal of cataract and refractive surgery.

[85]  D. Gatinel,et al.  Bilateral loss in the quality of vision associated with anterior corneal protrusion after hyperopic LASIK followed by intrastromal femtolaser-assisted incisions. , 2010, Journal of cataract and refractive surgery.

[86]  T. Berendschot,et al.  Dissatisfaction after implantation of multifocal intraocular lenses , 2011, Journal of cataract and refractive surgery.