论文信息 - Teratogenic Response by Hamsters, Rats and Mice to Aflatoxin B1

Teratogenic Response by Hamsters, Rats and Mice to Aflatoxin B1

PEANUTS and cereals may become contaminated with Aspergillus flavus, a mould of which the metabolites (aflatoxins) are potent carcinogens for rat liver1,2. One of these metabolites, aflatoxin B1 is a strong teratogen for the hamster3, but its effect in rats is equivocal4,5. It has been demonstrated that it binds to DNA in vitro and alters RNA metabolism in vivo6.

[1] H. Kalter,et al. The experimental production of cleft palate with cortisone and other hormones. , 1954, Journal of cellular physiology. Supplement.

[2] H. Kalter,et al. Experimental production of congenital maiformations in mammals by metabolic procedure. , 1959, Physiological reviews.

[3] C. W. Hesseltine,et al. Mycotoxins in Foodstuffs , 1966 .

[4] J. M. Barnes,et al. Carcinogenic Activity of Aflatoxin to Rats , 1964, Nature.

[5] J. DiPaolo,et al. Malformations induced in the mouse by thalidomide , 1964, The Anatomical record.

[6] M. Sporn,et al. Aflatoxin B1: Binding to DNA in vitro and Alteration of RNA Metabolism in vivo , 1966, Science.