论文信息 - Direct characterization of radial modulus of DNA nanotube by AFM nanoindentation

Direct characterization of radial modulus of DNA nanotube by AFM nanoindentation

DNA origami in a nanotube configuration is increasingly attractive for the creation of new structural systems that can confine or encapsulate a variety of nanoscale materials, but utilization as a functional mechanical component depends on understanding crucial properties such as the radial mechanical property that has rarely been studied. Here, we report the direct characterization of the radial modulus of a DNA nanotube by AFM nanoindentation. A corrected Hertz model was employed to interpret the measured force versus distance data. The biphasic material properties of the DNA nanotube were characterized for the first time and indicate a radial electrostatic modulus of about 10 ± 3 MPa in the small region where force was applied, and a radial elastic modulus of about 63 ± 20 MPa in a larger region.

[1] P. Rothemund. Folding DNA to create nanoscale shapes and patterns , 2006, Nature.

[2] M. Bathe,et al. Quantitative prediction of 3D solution shape and flexibility of nucleic acid nanostructures , 2011, Nucleic acids research.

[3] R. Seidel,et al. Direct mechanical measurements reveal the material properties of three-dimensional DNA origami. , 2011, Nano letters.

[4] S. Cocco,et al. Theoretical models for single-molecule DNA and RNA experiments: from elasticity to unzipping , 2002, cond-mat/0206238.

[5] Tim Liedl,et al. Nanoscale structure and microscale stiffness of DNA nanotubes. , 2013, ACS nano.

[6] N. Seeman,et al. Design and characterization of 1D nanotubes and 2D periodic arrays self-assembled from DNA multi-helix bundles. , 2012, Journal of the American Chemical Society.

[7] Osamu Tabata,et al. A Closer Look at DNA Nanotechnology , 2010, IEEE Nanotechnology Magazine.

[8] E. Winfree,et al. Design and characterization of programmable DNA nanotubes. , 2004, Journal of the American Chemical Society.

[9] Hao Yan,et al. DNA origami as a carrier for circumvention of drug resistance. , 2012, Journal of the American Chemical Society.

[10] F. Simmel,et al. DNA-based self-assembly of chiral plasmonic nanostructures with tailored optical response , 2011, Nature.

[11] Weidian C. Shen,et al. Investigation of the radial compression of carbon nanotubes with a scanning probe microscope , 2000, Physical review letters.