Diagnosis of Alzheimer Diseases in Early Step Using SVM (Support Vector Machine)

Alzheimer is a disease that affects the brain. It causes degeneration of nerve cells (neurons) and in particular cells involved in memory and intellectual functions. Early diagnosis of Alzheimer Diseases (AD) raises ethical questions, since there is, at present, no cure to offer to patients and medicines from therapeutic trials appear to slow the progression of the disease as moderate, accompanying side effects sometimes severe. In this context, analysis of medical images became, for clinical applications, an essential tool because it provides effective assistance both at diagnosis therapeutic follow-up. Computer Assisted Diagnostic systems (CAD) is one of the possible solutions to efficiently manage these images. In our work, we proposed an application to detect Alzheimer's diseases. For detecting the disease in early stage we used the three sections: frontal to extract the Hippocampus (H), Sagittal to analysis the Corpus Callosum (CC) and axial to work with the variation features of the Cortex(C). Our method of classification is based on Support Vector Machine (SVM). The proposed system yields a 90.66% accuracy in the early diagnosis of the AD.

[1]  R. Mayeux,et al.  Caloric intake and the risk of Alzheimer disease. , 2002, Archives of neurology.

[2]  I. Shapira The Nun Study. , 2008, Journal of the American Dental Association.

[3]  George W Rebok,et al.  Effect of memory impairment on training outcomes in ACTIVE , 2007, Journal of the International Neuropsychological Society.

[4]  E. Esposito,et al.  A review of specific dietary antioxidants and the effects on biochemical mechanisms related to neurodegenerative processes , 2002, Neurobiology of Aging.

[5]  John J Sidtis,et al.  Sexual dimorphism in the human corpus callosum: an MRI study using the OASIS brain database. , 2013, Cerebral cortex.

[6]  R. Tibshirani,et al.  Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins , 2007, Nature Medicine.

[7]  F. Panza,et al.  Mediterranean diet and cognitive decline , 2004, Public Health Nutrition.

[8]  Babak A. Ardekani,et al.  Corpus callosum shape changes in early Alzheimer’s disease: an MRI study using the OASIS brain database , 2013, Brain Structure and Function.

[9]  K. Buckwalter,et al.  Evidence supporting nutritional interventions for persons in early stage Alzheimer’s disease (AD) , 2008, The journal of nutrition, health & aging.

[10]  A. Verma,et al.  Mediterranean Diet and Risk for Alzheimer's Disease , 2008 .

[11]  Rossana Salerno-Kennedy,et al.  Relationship between dementia and nutrition-related factors and disorders: an overview. , 2005, International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.

[12]  M. Mattson Neuroprotective signaling and the aging brain: take away my food and let me run 1 1 Published on the World Wide Web on 24 August 2000. , 2000, Brain Research.

[13]  D. Bennett,et al.  Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. , 2003, Archives of neurology.

[14]  P. Barberger‐Gateau,et al.  Nutritional factors and risk of incident dementia in the PAQUID longitudinal cohort. , 2004, The journal of nutrition, health & aging.

[15]  V. Solfrizzi,et al.  The role of diet in cognitive decline , 2003, Journal of Neural Transmission.

[16]  S. Segura-Muñoz,et al.  Aluminum as a risk factor for Alzheimer's disease. , 2008, Revista latino-americana de enfermagem.

[17]  J. Foster,et al.  Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. , 2008, JAMA.

[18]  Yaakov Stern,et al.  Mediterranean diet and Alzheimer disease mortality , 2007, Neurology.