Microvascular endothelial cell heterogeneity: general concepts and pharmacological consequences for anti-angiogenic therapy of cancer
暂无分享,去创建一个
[1] M. Raica,et al. Immunohistochemical expression of vascular endothelial growth factor A (VEGF), and its receptors (VEGFR1, 2) in normal and pathologic conditions of the human thymus. , 2008, Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft.
[2] J. Tonn,et al. Expression of Integrin αvβ3 in Gliomas Correlates with Tumor Grade and Is not Restricted to Tumor Vasculature , 2008, Brain pathology.
[3] G. Garcı́a-Cardeña,et al. Regulation of arterial-venous differences in tumor necrosis factor responsiveness of endothelial cells by anatomic context. , 2008, The American journal of pathology.
[4] M. Shindoh,et al. Understanding tumor endothelial cell abnormalities to develop ideal anti‐angiogenic therapies , 2008, Cancer science.
[5] Mariaelena Pierobon,et al. Multiplexed cell signaling analysis of human breast cancer applications for personalized therapy. , 2008, Journal of proteome research.
[6] I. Fidler,et al. Inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation on tumor-associated endothelial cells leads to treatment of orthotopic human colon cancer in nude mice. , 2007, Neoplasia.
[7] I. Fidler,et al. Intratumoral heterogeneity for expression of tyrosine kinase growth factor receptors in human colon cancer surgical specimens and orthotopic tumors. , 2007, The American journal of pathology.
[8] D. Fliser,et al. Vascular endothelial damage and repair in antineutrophil cytoplasmic antibody-associated vasculitis. , 2007, Arthritis and rheumatism.
[9] S. Jalkanen,et al. VAP-1 and CD73, endothelial cell surface enzymes in leukocyte extravasation. , 2007, Arteriosclerosis, thrombosis, and vascular biology.
[10] Andrei Iagaru,et al. Molecular imaging can accelerate anti-angiogenic drug development and testing , 2007, Nature Clinical Practice Oncology.
[11] Jordan S. Pober,et al. Evolving functions of endothelial cells in inflammation , 2007, Nature Reviews Immunology.
[12] J. Rak,et al. Atherosclerosis and vascular aging as modifiers of tumor progression, angiogenesis, and responsiveness to therapy. , 2007, The American journal of pathology.
[13] Yihai Cao,et al. Angiogenic factors FGF2 and PDGF-BB synergistically promote murine tumor neovascularization and metastasis. , 2007, The Journal of clinical investigation.
[14] D. Hicklin,et al. Review: Monoclonal Antibodies to the Vascular Endothelial Growth Factor Receptor-2 in Cancer Therapy , 2007, Clinical Cancer Research.
[15] A. Kribben,et al. Acute and chronic microvascular alterations in a mouse model of ischemic acute kidney injury. , 2007, American journal of physiology. Renal physiology.
[16] Arjan W. Griffioen,et al. Tumour vascularization: sprouting angiogenesis and beyond , 2007, Cancer and Metastasis Reviews.
[17] M. van Meurs,et al. EARLY ORGAN-SPECIFIC ENDOTHELIAL ACTIVATION DURING HEMORRHAGIC SHOCK AND RESUSCITATION , 2007, Shock.
[18] C. Kallenberg,et al. Site-Specific Inhibition of Glomerulonephritis Progression by Targeted Delivery of Dexamethasone to Glomerular Endothelium , 2007, Molecular Pharmacology.
[19] R. Stan. Endothelial stomatal and fenestral diaphragms in normal vessels and angiogenesis , 2007, Journal of cellular and molecular medicine.
[20] S. Seaman,et al. Genes that distinguish physiological and pathological angiogenesis. , 2007, Cancer cell.
[21] Tracy T Batchelor,et al. VEGF-targeted cancer therapy strategies: current progress, hurdles and future prospects. , 2007, Trends in molecular medicine.
[22] Po-Len Liu,et al. High Glucose Impairs Early and Late Endothelial Progenitor Cells by Modifying Nitric Oxide–Related but Not Oxidative Stress–Mediated Mechanisms , 2007, Diabetes.
[23] T. Roskams,et al. High-grade clear cell renal cell carcinoma has a higher angiogenic activity than low-grade renal cell carcinoma based on histomorphological quantification and qRT–PCR mRNA expression profile , 2007, British Journal of Cancer.
[24] D. Hicklin,et al. Simultaneous blockade of VEGFR‐1 and VEGFR‐2 activation is necessary to efficiently inhibit experimental melanoma growth and metastasis formation , 2007, International journal of cancer.
[25] Shayn M Peirce,et al. EphB4 Expression Along Adult Rat Microvascular Networks: EphB4 Is More Than a Venous Specific Marker , 2007, Microcirculation.
[26] George Coukos,et al. Tumor vascular proteins as biomarkers in ovarian cancer. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[27] R. de Martin,et al. Resolution of inflammation: Intracellular feedback loops in the endothelium , 2007, Thrombosis and Haemostasis.
[28] William C. Aird,et al. Phenotypic Heterogeneity of the Endothelium: I. Structure, Function, and Mechanisms , 2007, Circulation research.
[29] W. Aird. Phenotypic Heterogeneity of the Endothelium: II. Representative Vascular Beds , 2007, Circulation research.
[30] D. Hume,et al. Histone Deacetylase Inhibitor Reduces Monocyte Adhesion to Endothelium Through the Suppression of Vascular Cell Adhesion Molecule-1 Expression , 2006, Arteriosclerosis, thrombosis, and vascular biology.
[31] Terri L. McKay,et al. A VEGF165-induced phenotypic switch from increased vessel density to increased vessel diameter and increased endothelial NOS activity. , 2006, Microvascular research.
[32] D. McDonald,et al. Rapid vascular regrowth in tumors after reversal of VEGF inhibition. , 2006, The Journal of clinical investigation.
[33] D. Hicklin,et al. Therapy-Induced Acute Recruitment of Circulating Endothelial Progenitor Cells to Tumors , 2006, Science.
[34] C. Ferran. Protective Genes in the Vessel Wall: Modulators of Graft Survival and Function , 2006, Transplantation.
[35] H. Dvorak,et al. Permeability properties of tumor surrogate blood vessels induced by VEGF-A , 2006, Laboratory Investigation.
[36] L. Claesson‐Welsh,et al. VEGF receptor signalling ? in control of vascular function , 2006, Nature Reviews Molecular Cell Biology.
[37] L. V. D. Heuvel,et al. Conditionally immortalized human glomerular endothelial cells expressing fenestrations in response to VEGF. , 2006, Kidney international.
[38] F. Bosman,et al. Immunohistochemical Expression of Endothelial Markers CD31, CD34, von Willebrand Factor, and Fli-1 in Normal Human Tissues , 2006, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
[39] S. Groshen,et al. Expression and significance of vascular endothelial growth factor receptor 2 in bladder cancer. , 2006, The Journal of urology.
[40] W. Aird. Mechanisms of endothelial cell heterogeneity in health and disease. , 2006, Circulation research.
[41] D. Dumont,et al. Heterogeneity of Tie2 expression in tumor microcirculation: influence of cancer type, implantation site, and response to therapy. , 2005, The American journal of pathology.
[42] S. Madden,et al. Plasmalemmal Vesicle Associated Protein-1 Is a Novel Marker Implicated in Brain Tumor Angiogenesis , 2005, Clinical Cancer Research.
[43] Oriol Casanovas,et al. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. , 2005, Cancer cell.
[44] A. Sood,et al. Antivascular Therapy for Orthotopic Human Ovarian Carcinoma through Blockade of the Vascular Endothelial Growth Factor and Epidermal Growth Factor Receptors , 2005, Clinical Cancer Research.
[45] R. Jain,et al. NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels. , 2005, The Journal of clinical investigation.
[46] Chryso Kanthou,et al. Disrupting tumour blood vessels , 2005, Nature Reviews Cancer.
[47] I. Dreher,et al. The human VE-cadherin promoter is subjected to organ-specific regulation and is activated in tumour angiogenesis , 2005, Oncogene.
[48] A. Bikfalvi,et al. Molecular mechanisms of tumor vascularization. , 2005, Critical reviews in oncology/hematology.
[49] L. Ellis,et al. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[50] M. Ozawa,et al. Targeting pancreatic islets with phage display assisted by laser pressure catapult microdissection. , 2005, The American journal of pathology.
[51] J. Pober,et al. Induction, differentiation, and remodeling of blood vessels after transplantation of Bcl-2-transduced endothelial cells. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[52] R. Jain. Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy , 2005, Science.
[53] Dhara N. Amin,et al. Tumor-Associated Endothelial Cells with Cytogenetic Abnormalities , 2004, Cancer Research.
[54] Pieter Wesseling,et al. Antiangiogenic Therapy of Cerebral Melanoma Metastases Results in Sustained Tumor Progression via Vessel Co-Option , 2004, Clinical Cancer Research.
[55] Oswald Wagner,et al. Lymphoma-specific genetic aberrations in microvascular endothelial cells in B-cell lymphomas. , 2004, The New England journal of medicine.
[56] L. Ellis,et al. Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation. , 2004, Journal of the National Cancer Institute.
[57] J. Berlin,et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. , 2004, The New England journal of medicine.
[58] Robert S. Kerbel,et al. The anti-angiogenic basis of metronomic chemotherapy , 2004, Nature Reviews Cancer.
[59] H. Blau,et al. Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis. , 2004, The Journal of clinical investigation.
[60] Ricky T. Tong,et al. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer , 2004, Nature Medicine.
[61] H. Dvorak,et al. Ultrastructural Localization of Platelet Endothelial Cell Adhesion Molecule (PECAM-1, CD31) in Vascular Endothelium , 2004, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
[62] D. Hanahan,et al. Stage-specific vascular markers revealed by phage display in a mouse model of pancreatic islet tumorigenesis. , 2003, Cancer cell.
[63] Erkki Ruoslahti,et al. Progressive vascular changes in a transgenic mouse model of squamous cell carcinoma. , 2003, Cancer cell.
[64] David Botstein,et al. Endothelial cell diversity revealed by global expression profiling , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[65] Tarik Tihan,et al. The hypoxic response of tumors is dependent on their microenvironment. , 2003, Cancer cell.
[66] M. Hendrix,et al. Angiogenesis: Vasculogenic mimicry and tumour-cell plasticity: lessons from melanoma , 2003, Nature Reviews Cancer.
[67] D. Hanahan,et al. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. , 2003, The Journal of clinical investigation.
[68] J. Nelson,et al. The endothelin axis: emerging role in cancer , 2003, Nature Reviews Cancer.
[69] Wadih Arap,et al. Probing the structural and molecular diversity of tumor vasculature. , 2002, Trends in molecular medicine.
[70] K. Müller,et al. Expression of the endothelial markers PECAM-1, vWf, and CD34 in vivo and in vitro. , 2002, Experimental and molecular pathology.
[71] A. Bankfalvi,et al. Human endomucin: distribution pattern, expression on high endothelial venules, and decoration with the MECA-79 epitope. , 2002, The American journal of pathology.
[72] J. Cherrington,et al. SU6668 inhibits Flk‐1/KDR and PDGFRβ in vivo, resulting in rapid apoptosis of tumor vasculature and tumor regression in mice , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[73] R. Jain,et al. Role of host microenvironment in angiogenesis and microvascular functions in human breast cancer xenografts: mammary fat pad versus cranial tumors. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.
[74] Rakesh K Jain,et al. Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. , 2002, The American journal of pathology.
[75] G. Hämmerling,et al. Transformation of the microvascular system during multistage tumorigenesis , 2002, International journal of cancer.
[76] Lei Xu,et al. Pancreas Microenvironment Promotes VEGF Expression and Tumor Growth: Novel Window Models for Pancreatic Tumor Angiogenesis and Microcirculation , 2001, Laboratory Investigation.
[77] L. Ellis,et al. In vivo intracellular signaling as a marker of antiangiogenic activity. , 2001, Cancer research.
[78] J. Folkman,et al. Heterogeneity of angiogenic activity in a human liposarcoma: a proposed mechanism for "no take" of human tumors in mice. , 2001, Journal of the National Cancer Institute.
[79] M. Maio,et al. Endoglin: An accessory component of the TGF‐β‐binding receptor‐complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies , 2001, Journal of cellular physiology.
[80] P. Carmeliet,et al. Heterogeneous vascular dependence of tumor cell populations. , 2001, The American journal of pathology.
[81] P. Carmeliet,et al. Molecular mechanisms of blood vessel growth. , 2001, Cardiovascular research.
[82] G. Yancopoulos,et al. Ephrin-B2 selectively marks arterial vessels and neovascularization sites in the adult, with expression in both endothelial and smooth-muscle cells. , 2001, Developmental biology.
[83] P. Kubes,et al. A Role for Platelets and Endothelial Selectins in Tumor Necrosis Factor-&agr;–Induced Leukocyte Recruitment in the Brain Microvasculature , 2000, Circulation research.
[84] K. Kinzler,et al. Genes expressed in human tumor endothelium. , 2000, Science.
[85] Cherrington,et al. SU6668 is a potent antiangiogenic and antitumor agent that induces regression of established tumors. , 2000, Cancer research.
[86] A. Griffioen,et al. Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. , 2000, Pharmacological reviews.
[87] J. Mestan,et al. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. , 2000, Cancer research.
[88] P. Meltzer,et al. Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry. , 1999, The American journal of pathology.
[89] G. Yancopoulos,et al. Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF. , 1999, Science.
[90] D. Hanahan,et al. Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. , 1999, Science.
[91] D. Pode,et al. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal. , 1999, The Journal of clinical investigation.
[92] C. Bucana,et al. Spatial and temporal expression of angiogenic molecules during tumor growth and progression. , 1998, Oncology research.
[93] W. Cavenee,et al. Host microvasculature influence on tumor vascular morphology and endothelial gene expression. , 1998, The American journal of pathology.
[94] Thomas Boehm,et al. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance , 1997, Nature.
[95] F. Dignat-George,et al. Immunologic phenotype of cultured endothelial cells: quantitative analysis of cell surface molecules. , 1997, Tissue antigens.
[96] M. Dewhirst,et al. Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues. , 1997, Circulation research.
[97] R K Jain,et al. Effect of host microenvironment on the microcirculation of human colon adenocarcinoma. , 1997, The American journal of pathology.
[98] C. Garlanda,et al. Heterogeneity of endothelial cells. Specific markers. , 1997, Arteriosclerosis, thrombosis, and vascular biology.
[99] CeciliaGarlanda,et al. Heterogeneity of Endothelial Cells , 1997 .
[100] M. Cooper,et al. Advanced glycation end products and their receptors co-localise in rat organs susceptible to diabetic microvascular injury , 1997, Diabetologia.
[101] Grietje Molema,et al. Tumor Infarction in Mice by Antibody-Directed Targeting of Tissue Factor to Tumor Vasculature , 1997, Science.
[102] C. Bucana,et al. Organ site-dependent expression of basic fibroblast growth factor in human renal cell carcinoma cells. , 1994, The American journal of pathology.
[103] S. Jalkanen,et al. Induction and function of vascular adhesion protein-1 at sites of inflammation , 1993, The Journal of experimental medicine.
[104] C. Haudenschild,et al. Preservation of thrombomodulin antigen on vascular and extravascular surfaces. , 1987, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
[105] G. Heppner,et al. Mutagenic activity of tumor-associated macrophages in Salmonella typhimurium strains TA98 and TA 100. , 1984, Cancer research.
[106] J. Denekamp,et al. Endothelial proliferation in tumours and normal tissues: continuous labelling studies. , 1984, British Journal of Cancer.
[107] I. Fidler,et al. Biological diversity in metastatic neoplasms: origins and implications. , 1982, Science.
[108] J. Folkman. Tumor angiogenesis: therapeutic implications. , 1971, The New England journal of medicine.
[109] J Folkman,et al. Transplacental carcinogenesis by stilbestrol. , 1971, The New England journal of medicine.
[110] P. Gimotty,et al. Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy , 2008, Nature Medicine.
[111] H. Dvorak,et al. Tumor Blood Vessels , 2008 .
[112] Lawrence D. True,et al. Differential expression of angiogenesis associated genes in prostate cancer bone, liver and lymph node metastases , 2007, Clinical & Experimental Metastasis.
[113] J. Folkman. Angiogenesis: an organizing principle for drug discovery? , 2007, Nature reviews. Drug discovery.
[114] C. Patterson. Endothelial Biomedicine: Endothelial Cell Differentiation and Vascular Development in Mammals , 2007 .
[115] T. Stevens. Endothelial Biomedicine: Microheterogeneity of Lung Endothelium , 2007 .
[116] H. Dvorak. Endothelial Biomedicine: Tumor Blood Vessels , 2007 .
[117] Ming-Yu Liu,et al. Increased angiogenic capabilities of endothelial cells from microvessels of malignant human gliomas. , 2006, International immunopharmacology.
[118] Jeffrey W. Clark,et al. Lessons from phase III clinical trials on anti-VEGF therapy for cancer , 2006, Nature Clinical Practice Oncology.
[119] E. van Marck,et al. Endothelial cell apoptosis in the context of quantification of angiogenesis in solid human adenocarcinomas: a novel double immunolabelling technique to identify endothelial cell apoptosis. , 2006, European journal of cancer.
[120] P. Rieckmann,et al. Isolation and Culture of Microvascular Endothelial Cells from Gliomas of Different WHO Grades , 2005, Journal of Neuro-Oncology.
[121] A. Foss,et al. Endothelial Cells of Tumor Vessels: Abnormal but not Absent , 2004, Cancer and Metastasis Reviews.
[122] G. Garcı́a-Cardeña,et al. Early adaptive responses of the vascular wall during venous arterialization in mice. , 2004, The American journal of pathology.
[123] J. Papadimitriou,et al. Comparison of vascularity and angiogenesis in primary invasive mammary carcinomas and in their respective axillary lymph node metastases , 2004, Clinical & Experimental Metastasis.
[124] C. Betsholtz,et al. Analysis of Mural Cell Recruitment to Tumor Vessels , 2002, Circulation.
[125] C. Fu,et al. Vascular expression of the alpha(v)beta(3)-integrin in lung and other organs. , 2000, American journal of physiology. Lung cellular and molecular physiology.
[126] Dian Feng,et al. Heterogeneity of the Angiogenic Response Induced in Different Normal Adult Tissues by Vascular Permeability Factor/Vascular Endothelial Growth Factor , 2000, Laboratory Investigation.
[127] Martin R. Schneider,et al. PTK 787 / ZK 222584 , a Novel and Potent Inhibitor of Vascular Endothelial Growth Factor Receptor Tyrosine Kinases , Impairs Vascular Endothelial Growth Factor-induced Responses and Tumor Growth after Oral Administration , 2000 .
[128] Baljit Singh,et al. Vascular expression of the αvβ3-integrin in lung and other organs , 2000 .
[129] H. Dvorak,et al. Vascular permeability factor/vascular endothelial growth factor: a multifunctional angiogenic cytokine. , 1997, EXS.
[130] L. Ellis,et al. In situ mRNA hybridization technique for analysis of metastasis-related genes in human colon carcinoma cells. , 1995, The American journal of pathology.
[131] J. Winer,et al. Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues. , 1992, The Journal of clinical investigation.
[132] G. Heppner. Tumor heterogeneity. , 1984, Cancer research.