IL-5 and eosinophilia.

[1]  J. Parkin,et al.  Treatment of patients with the hypereosinophilic syndrome with mepolizumab. , 2008, The New England journal of medicine.

[2]  K. Takatsu,et al.  Oct2 enhances antibody-secreting cell differentiation through regulation of IL-5 receptor α chain expression on activated B cells , 2008, The Journal of experimental medicine.

[3]  Angel F. Lopez,et al.  The IL-3/IL-5/GM-CSF Common β Receptor Plays a Pivotal Role in the Regulation of Th2 Immunity and Allergic Airway Inflammation1 , 2008, The Journal of Immunology.

[4]  W. Busse,et al.  A study to evaluate safety and efficacy of mepolizumab in patients with moderate persistent asthma. , 2007, American journal of respiratory and critical care medicine.

[5]  T. Yamamura,et al.  Invariant NKT Cells Biased for IL-5 Production Act as Crucial Regulators of Inflammation1 , 2007, The Journal of Immunology.

[6]  J. Lei,et al.  JAK kinases control IL‐5 receptor ubiquitination, degradation, and internalization , 2007, Journal of leukocyte biology.

[7]  Hiroshi Nakajima,et al.  Role of Cytokines in Allergic Airway Inflammation , 2006, International Archives of Allergy and Immunology.

[8]  Daniel G Tenen,et al.  The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages. , 2006, Genes & development.

[9]  K. Takatsu,et al.  Interleukin‐5 regulates genes involved in B‐cell terminal maturation , 2006, Immunology.

[10]  H. J. Wilkins,et al.  Hypereosinophilic syndrome: An update , 2005, American journal of hematology.

[11]  K. Akashi,et al.  Identification of eosinophil lineage–committed progenitors in the murine bone marrow , 2005, The Journal of experimental medicine.

[12]  A. B. Kay,et al.  The role of eosinophils in the pathogenesis of asthma. , 2005, Trends in molecular medicine.

[13]  M. Kubo,et al.  Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness , 2005, The Journal of experimental medicine.

[14]  M. Kuraoka,et al.  CD4–c‐kit–CD3ϵ–IL‐2Rα+ Peyer's patch cells are a novel cell subset which secrete IL‐5 in response to IL‐2: implications for their role in IgA production , 2004 .

[15]  K. Takatsu,et al.  The Role of IL-5 for Mature B-1 Cells in Homeostatic Proliferation, Cell Survival, and Ig Production 1 , 2004, The Journal of Immunology.

[16]  Taiji Ito,et al.  Bruton's tyrosine kinase (Btk) enhances transcriptional co-activation activity of BAM11, a Btk-associated molecule of a subunit of SWI/SNF complexes. , 2004, International immunology.

[17]  Lauren Cohn,et al.  Asthma: mechanisms of disease persistence and progression. , 2004, Annual review of immunology.

[18]  J. Boyce,et al.  Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes. , 2004, The Journal of allergy and clinical immunology.

[19]  J. Ring,et al.  Use of an anti-interleukin-5 antibody in the hypereosinophilic syndrome with eosinophilic dermatitis. , 2003, The New England journal of medicine.

[20]  K. Calame,et al.  Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. , 2003, Immunity.

[21]  D. Postma,et al.  Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study. , 2003, American journal of respiratory and critical care medicine.

[22]  S. Phipps,et al.  Differential Regulation of Human Eosinophil IL-3, IL-5, and GM-CSF Receptor α-Chain Expression by Cytokines: IL-3, IL-5, and GM-CSF Down-Regulate IL-5 Receptor α Expression with Loss of IL-5 Responsiveness, but Up-Regulate IL-3 Receptor α Expression 1 , 2003, The Journal of Immunology.

[23]  K. Shitara,et al.  The Absence of Fucose but Not the Presence of Galactose or Bisecting N-Acetylglucosamine of Human IgG1 Complex-type Oligosaccharides Shows the Critical Role of Enhancing Antibody-dependent Cellular Cytotoxicity* , 2003, The Journal of Biological Chemistry.

[24]  Lin Ying Liu,et al.  Decreased Expression of Membrane IL-5 Receptor α on Human Eosinophils: I. Loss of Membrane IL-5 Receptor α on Airway Eosinophils and Increased Soluble IL-5 Receptor α in the Airway After Allergen Challenge1 , 2002, The Journal of Immunology.

[25]  Lin Ying Liu,et al.  Decreased Expression of Membrane IL-5 Receptor α on Human Eosinophils: II. IL-5 Down-Modulates Its Receptor Via a Proteinase-Mediated Process1 , 2002, The Journal of Immunology.

[26]  Kenneth M. Murphy,et al.  Decision making in the immune system: The lineage decisions of helper T cells , 2002, Nature Reviews Immunology.

[27]  M. Martinez-Moczygemba,et al.  Proteasomal regulation of betac signaling reveals a novel mechanism for cytokine receptor heterotypic desensitization. , 2001, The Journal of clinical investigation.

[28]  K. Takatsu,et al.  Essential Role of Stat5 for IL-5-Dependent IgH Switch Recombination in Mouse B Cells1 , 2001, The Journal of Immunology.

[29]  M. Bates,et al.  Transduction of a dominant-negative H-Ras into human eosinophils attenuates extracellular signal-regulated kinase activation and interleukin-5-mediated cell viability. , 2001, Blood.

[30]  R. Baron,et al.  Spred is a Sprouty-related suppressor of Ras signalling , 2001, Nature.

[31]  M. Katsuki,et al.  Functional dissection of the cytoplasmic subregions of the interleukin‐5 receptor α chain in growth and immunoglobulin G1 switch recombination of B cells , 2001, Immunology.

[32]  E. Gelfand,et al.  IL‐5‐induced airway eosinophilia – the key to asthma? , 2001, Immunological reviews.

[33]  A B Kay,et al.  Allergy and allergic diseases. First of two parts. , 2001, The New England journal of medicine.

[34]  K. Chung,et al.  Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsìveness, and the late asthmatic response , 2000, The Lancet.

[35]  A. O’Garra,et al.  The molecular basis of T helper 1 and T helper 2 cell differentiation. , 2000, Trends in cell biology.

[36]  M. Hirano,et al.  Identification and characterization of a molecule, BAM11, that associates with the pleckstrin homology domain of mouse Btk. , 2000, International immunology.

[37]  Yamada,et al.  Allergen‐induced airway inflammation and bronchial responsiveness in interleukin‐5 receptor α chain‐deficient mice , 2000, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[38]  W. Leonard,et al.  Both stat5a and stat5b are required for antigen-induced eosinophil and T-cell recruitment into the tissue. , 2000, Blood.

[39]  R. Dummer,et al.  Correction: Abnormal Clones of T Cells Producing Interleukin-5 in Idiopathic Eosinophilia. , 1999, The New England journal of medicine.

[40]  H. Kiyono,et al.  Deficiency of IL-5 receptor alpha-chain selectively influences the development of the common mucosal immune system independent IgA-producing B-1 cell in mucosa-associated tissues. , 1999, Journal of immunology.

[41]  M. Wills-Karp Immunologic basis of antigen-induced airway hyperresponsiveness. , 1999, Annual review of immunology.

[42]  R. Garofalo,et al.  Lyn, Jak2, and Raf-1 Kinases Are Critical for the Antiapoptotic Effect of Interleukin 5, whereas only Raf-1 Kinase Is Essential for Eosinophil Activation and Degranulation , 1998, The Journal of experimental medicine.

[43]  K. Takatsu,et al.  JAK2 and JAK1 Constitutively Associate With an Interleukin-5 (IL-5) Receptor α and βc Subunit, Respectively, and Are Activated Upon IL-5 Stimulation , 1998 .

[44]  J. Lammers,et al.  Analysis of signal transduction pathways in human eosinophils activated by chemoattractants and the T-helper 2-derived cytokines interleukin-4 and interleukin-5. , 1998, Blood.

[45]  K. Takatsu,et al.  Interleukin 5 and B cell differentiation. , 1998, Cytokine & growth factor reviews.

[46]  M. Sporn Growth factors and cytokines in health and disease , 1997 .

[47]  H. Xu,et al.  Infiltration of eosinophils into the asthmatic airways caused by interleukin 5. , 1997, American journal of respiratory cell and molecular biology.

[48]  J. Miyazaki,et al.  Defective B-1 cell development and impaired immunity against Angiostrongylus cantonensis in IL-5R alpha-deficient mice. , 1996, Immunity.

[49]  P. Foster,et al.  Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model , 1996, The Journal of experimental medicine.

[50]  P. Hodgkin,et al.  IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses. , 1996, Immunity.

[51]  K. Takatsu,et al.  CD38 ligation induces tyrosine phosphorylation of Bruton tyrosine kinase and enhanced expression of interleukin 5-receptor alpha chain: synergistic effects with interleukin 5. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[52]  L. Lanier,et al.  Production of IL-5 by human NK cells and regulation of IL-5 secretion by IL-4, IL-10, and IL-12. , 1995, Journal of immunology.

[53]  R. Alam,et al.  The intracellular signal transduction mechanism of interleukin 5 in eosinophils: the involvement of lyn tyrosine kinase and the Ras-Raf-1- MEK-microtubule-associated protein kinase pathway , 1995, The Journal of experimental medicine.

[54]  K. Takatsu,et al.  Antibody against interleukin-5 prevents antigen-induced eosinophil infiltration and bronchial hyperreactivity in the guinea pig airways. , 1995, Immunology letters.

[55]  T. Watanabe,et al.  IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases , 1994, The Journal of experimental medicine.

[56]  M. Goldman,et al.  Brief report: clonal proliferation of type 2 helper T cells in a man with the hypereosinophilic syndrome. , 1994, The New England journal of medicine.

[57]  Y. Hitoshi,et al.  Interleukin-5 and its receptor system: implications in the immune system and inflammation. , 1994, Advances in immunology.

[58]  K. Takatsu,et al.  CD4+ T-lymphocytes and interleukin-5 mediate antigen-induced eosinophil infiltration into the mouse trachea. , 1992, The American review of respiratory disease.

[59]  S. Durham,et al.  Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. , 1992, The New England journal of medicine.

[60]  A. Capron,et al.  Interleukin 5 messenger RNA expression by eosinophils in the intestinal mucosa of patients with coeliac disease , 1992, The Journal of experimental medicine.

[61]  J. Bousquet,et al.  Eosinophilic inflammation in asthma. , 1990, The New England journal of medicine.