COMPARISON OF ANALGESIC EFFICACY AND EVALUATION OF 0.0625% BUPIVACAINE + 25MG TRAMADOL AND 0.1% ROPIVACAINE +25MG TRAMADOL ON LABOUR ANALGESIA

Background: The objective is to compare the analgesic efficacy and evaluation of 0.0625% bupivacaine + 25mg tramadol and 0.1% ropivacaine + 25mg tramadol on labour analgesia. Materials and Methods: This is a prospective randomized study conducted at Saheed Laxman Nayak Medical College and Hospital, Odisha, Institutional Ethics committee approval [project no - EC4(11)] from 3 rd September 2020 to 3 rd March 2022. Result: There were no statistically significant variation in the demographic profiles among the two groups. The maternal pulse rate and systolic blood pressure showed no significant difference among the two groups throughout the observation period. This trend indicates that both Ropivacaine + Tramadol and Bupivacaine + Tramadol is safe for labour analgesia at the concentrations and doses used in our study. Fetal heart rates were comparable between the two studied group at all the time and there was no statistically significant difference. Conclusion: Both ropivacaine and bupivacaine can provide comparable labor analgesia with high maternal satisfaction in the clinically used doses.

[1]  G. Karakoç,et al.  Comparison of bupivacaine and ropivacaine in combination with fentanyl used for walking epidural anesthesia in labor , 2017, Turkish journal of obstetrics and gynecology.

[2]  A. Hussain,et al.  Comparison of 0.1% Ropivacaine-Fentanyl with 0.1% Bupivacaine-Fentanyl Epidurally for Labour Analgesia , 2014 .

[3]  W. Mi,et al.  Efficacy and safety of local anesthetics bupivacaine, ropivacaine and levobupivacaine in combination with sufentanil in epidural anesthesia for labor and delivery: a meta-analysis , 2014, Current medical research and opinion.

[4]  S. Halpern,et al.  Focused review: ropivacaine versus bupivacaine for epidural labor analgesia. , 2011, Anesthesia and analgesia.

[5]  C. Wong,et al.  Labour analgesia and obstetric outcomes. , 2010, British journal of anaesthesia.

[6]  R. Shoukry,et al.  Effects of intrapartum epidural analgesia at high altitudes: maternal, fetal, and neonatal outcomes. A randomized controlled trial of two formulations of analgesics , 2010, Acta obstetricia et gynecologica Scandinavica.

[7]  Ehsan-ul-Haq,et al.  Walking epidural with low dose bupivacaine plus tramadol on normal labour in primipara. , 2010, Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.

[8]  H. Abedi,et al.  Women’s experience of pain during childbirth , 2010, Iranian journal of nursing and midwifery research.

[9]  S. Hossain,et al.  Local anesthetics and mode of delivery: bupivacaine versus ropivacaine versus levobupivacaine. , 2008, Anesthesia and analgesia.

[10]  D. Bick,et al.  Effect of low-dose mobile versus traditional epidural techniques on mode of delivery: a randomised controlled trial , 2001, The Lancet.

[11]  S. Datta,et al.  Is combined spinal-epidural analgesia associated with more rapid cervical dilation in nulliparous patients when compared with conventional epidural analgesia? , 1999, Anesthesiology.

[12]  M. Columb,et al.  Relative analgesic potencies of ropivacaine and bupivacaine for epidural analgesia in labor: implications for therapeutic indexes. , 1998, Anesthesiology.

[13]  F. Reynolds Does the left hand know what the right hand is doing? An appraisal of single enantiomer local anaesthetics. , 1997, International journal of obstetric anesthesia.

[14]  A. Fuchs,et al.  Effects of lumbar epidural analgesia on prostaglandin F2 alpha release and oxytocin secretion during labor. , 1993, Prostaglandins.

[15]  G A Albright,et al.  Cardiac arrest following regional anesthesia with etidocaine or bupivacaine. , 1979, Anesthesiology.

[16]  J. Scanlon,et al.  Neurobehavioral Responses and Drug Concentrations in Newborns after Maternal Epidural Anesthesia with Bupivacaine , 1976, Anesthesiology.

[17]  P. Slater,et al.  Extradural analgesia in obstetrics: a controlled trial of carbonated lignocaine and bupivacaine hydrochloride with or without adrenaline. , 1976, British journal of anaesthesia.

[18]  N. Raabe,et al.  Lumbar epidural analgesia with bupivacaine in labor. Drug concentration in maternal and neonatal blood at birth and during the first day of life. , 1975, American journal of obstetrics and gynecology.

[19]  J. Magar,et al.  Double blind comparison of combination of 0.1% ropivacaine and fentanyl to combination of 0.1% bupivacaine and fentanyl for extradural analgesia in labour , 2016, Journal of anaesthesiology, clinical pharmacology.